Results 41 to 50 of about 635,426 (265)

Optimal experiment selection for parameter estimation in biological differential equation models

BMC Bioinformatics, 2012
Background Parameter estimation in biological models is a common yet challenging problem. In this work we explore the problem for gene regulatory networks modeled by differential equations with unknown parameters, such as decay rates, reaction rates ...
Transtrum Mark K, Qiu Peng
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Age and Growth of Japanese Anchovy (Engraulis japonicus, Temminck & Schlegel, 1846) in Coastal Waters around Shandong Peninsula, China

Fishes
Japanese anchovy (Engraulis japonicus) is a small pelagic fish with commercial and ecological importance. In spite of its importance, in recent years, specific research on anchovy in the Shandong Peninsula area has been relatively scarce and outdated ...
Kalysta Fellatami, Wenchao Zhang, Chi Zhang, Shude Liu, Yongjun Tian   +4 more
doaj   +1 more source

Analysis of Practical Identifiability of a Viral Infection Model. [PDF]

PLoS ONE, 2016
Mathematical modelling approaches have granted a significant contribution to life sciences and beyond to understand experimental results. However, incomplete and inadequate assessments in parameter estimation practices hamper the parameter reliability ...
Van Kinh Nguyen, Frank Klawonn, Rafael Mikolajczyk, Esteban A Hernandez-Vargas   +3 more
doaj   +1 more source

Chromatographic parameter determination for complex biological feedstocks [PDF]

Biotechnology Progress, 2018
The application of mechanistic models for chromatography requires accurate model parameters. Especially for complex feedstocks such as a clarified cell harvest, this can still be an obstacle limiting the use of mechanistic models. Another commonly encountered obstacle is a limited amount of sample material and time to determine all
Silvia M. Pirrung, Diogo Parruca da Cruz, Alexander T. Hanke, Carmen Berends, Ruud F.W.C. Van Beckhoven, Michel H.M. Eppink, Marcel Ottens   +6 more
openaire   +4 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Telemetry System of Biological Parameters

Advances in Electrical and Electronic Engineering, 2005
The mobile telemetry system of biological parameters serves for reading and wireless data transfer of measured values of selected biological parameters to an outlying computer. It concerns basically long time monitoring of vital function of car pilot.The goal of this projects is to propose mobile telemetry system for reading, wireless transfer and ...
Spišák, J., Penhaker, M.
openaire   +2 more sources

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Biological characteristics for the spawners of chum salmon Oncorhynchus keta caught in the Indigirka River in 2023

Известия ТИНРО
The main biological parameters of chum salmon Oncorhynchus keta are presented for the spawners caught during the research expedition conducted to the lower reaches of Indigirka in August-September 2023.
A. I. Nikiforov, L. N. Karpova
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source