Results 101 to 110 of about 2,638,691 (365)

The effects of bioactive akermanite on physiochemical, drug-delivery, and biological properties of poly(lactide-co-glycolide) beads [PDF]

, 2011
Poly(lactide-co-glycolide) (PLGA) beads have been widely studied as a potential drug/protein carrier. The main shortcomings of PLGA beads are that they lack bioactivity and controllable drug-delivery ability, and their acidic degradation by-products can ...
Ara, Bittner, Brunner, Cleland, Crotts, Dittrich, Fu, Heidemann, Hench, Hong, Huang, Jeyanthi, Johnson, Juin, Keshaw, Kim, Kokubo, Li, Maquet, Mondal, Nam, Shi, Silver, Teixeira, Valerio, Verrier, Wang, Wu, Wu, Wu, Wu, Wu, Zolnik, Zreiqat   +33 more
core   +2 more sources

Elucidation of interface interactions between a dehydratase domain and an acyl carrier protein in cremimycin polyketide synthase

FEBS Letters, EarlyView.
In modular polyketide synthases, the dehydratase (DH) domain catalyzes the dehydration reaction of the β‐hydroxyacyl unit attached to the cognate acyl carrier protein (ACP) domain. However, it is unclear how DH interacts with ACP during the reaction. In this study, we identified DH–ACP interface residues, providing the first detailed insights into DH ...
Kaede Kotagiri, Haruka Tachibana, Daisuke Kawasaki, Taichi Chisuga, Toma Kashima, Shinya Fushinobu, Fumitaka Kudo, Tadashi Eguchi, Akimasa Miyanaga   +8 more
wiley   +1 more source

A two-stage, two-organism process for biohydrogen from glucose [PDF]

, 2006
H2 can potentially be produced in a two-stage biological process: the fermentation of glucose by Escherichia coli HD701 and the photofermentation of the residual medium by Rhodobacter sphaeroides O.U. 001. In a typical batch fermentation, E.
Macaskie, LE, Redwood, MD
core   +1 more source

Functional variation among LPMOs revealed by the inhibitory effects of cyanide and buffer ions

FEBS Letters, EarlyView.
This study addresses the inhibition of lytic polysaccharide monooxygenases (LPMOs) by cyanide and explains how and why the magnitude of observed inhibitory effects depends on the way LPMO reactions are setup and on the type of LPMO. Enzymes known as lytic polysaccharide monooxygenases (LPMOs) are mono‐copper polysaccharide‐degrading peroxygenases that ...
Ole Golten, Lorenz Schwaiger, Zarah Forsberg, Kelsi R. Hall, Anton A. Stepnov, Tom Z. Emrich‐Mills, Iván Ayuso‐Fernández, Morten Sørlie, Roland Ludwig, Åsmund Kjendseth Røhr, Vincent G. H. Eijsink   +10 more
wiley   +1 more source

Resistance-gene-directed discovery of a natural-product herbicide with a new mode of action. [PDF]

, 2018
Bioactive natural products have evolved to inhibit specific cellular targets and have served as lead molecules for health and agricultural applications for the past century1-3.
Bat-Erdene, Undramaa, Gan, Jianhua, Jacobsen, Steven E, Liu, Qikun, Nguyen, Calvin, Tang, Yi, Yan, Yan, Yuan, Shuguang, Zang, Xin, Zhou, Jiahai   +9 more
core  

Biological Carbon Sequestration and Carbon Trading Re-Visited [PDF]

, 2009
Biological activities that sequester carbon create CO2 offset credits that could obviate the need for reductions in fossil fuel use. Credits are earned by storing carbon in terrestrial ecosystems and wood products, although CO2 emissions are also ...
Kooten, G.C., van
core   +2 more sources

Dynamic control of catalysis within biological cells [PDF]

arXiv, 2011
We develop a theory of enzyme catalysis within biological cells where the substrate concentration [S](t) is time dependent, in contrast to the Michaelis-Menten theory that assumes a steady state. We find that the time varying concentration can combine, in a non-linear way, with the ruggedness of the free energy landscape of enzymes (discovered both in ...
arxiv  

Ablation of LRP6 in alpha‐smooth muscle actin‐expressing cells abrogates lung inflammation and fibrosis upon bleomycin‐induced lung injury

FEBS Letters, EarlyView.
Low‐density lipoprotein receptor‐related protein 6 (LRP6) is a key receptor for the Wnt antagonist Dickkopf1 (DKK1). DKK1 protein expression is induced in a bleomycin (BLM)‐induced lung injury model. We show that DKK1 induces proinflammatory and profibrotic genes in lung fibroblasts.
Eun‐Ah Sung, Mikhail G. Dozmorov, SuJeong Song, Theingi Aung, Min Hee Park, Patricia J. Sime, Wook‐Jin Chae   +6 more
wiley   +1 more source

Comparative effectiveness of H7N9 vaccines in healthy individuals

Human Vaccines & Immunotherapeutics, 2019
Background: Avian H7N9 influenza viruses possess a potential pandemic threat to public health worldwide, and have caused severe infection and high mortality in humans. A series of clinical trials of H7N9 vaccines have been completed.
Dan Zheng, Feixia Gao, Cheng Zhao, Yahong Ding, Yemin Cao, Tianhan Yang, Xuesong Xu, Ze Chen   +7 more
doaj   +1 more source

Unified approach to growth and aging in biological, technical and biotechnical systems [PDF]

arXiv, 2012
Complex systems, in many different scientific sectors, show coarse-grain properties with simple growth laws with respect to fundamental microscopic algorithms. We propose a classification scheme of growth laws which includes human aging, tumor (and/or tissue) growth, logistic and generalized logistic growth and the aging of technical devices.
arxiv