Results 181 to 190 of about 519,707 (250)

A cautionary tale for AI and machine learning in psychiatry. [PDF]

Transl Psychiatry
Chen ZS, Schultebraucks K, Wu W.
europepmc   +1 more source

HLA genotype testing for carbamazepine, oxcarbazepine and eslicarbazepine: A guideline developed by the UK Centre of Excellence in Regulatory Science and Innovation in Pharmacogenomics (CERSI‐PGx)

British Journal of Clinical Pharmacology, EarlyView.
Carbamazepine is licensed in the United Kingdom for the treatment of epilepsy, bipolar disorder and trigeminal neuralgia. The related compounds oxcarbazepine and eslicarbazepine are licensed for the treatment of epilepsy. These drugs can cause immune‐mediated hypersensitivity reactions, which typically affect the skin, and can be of variable severity ...
Lucy Galloway, Cinzia Dello Russo, Nicholas Bass, Elvira Bramon, Helen Cross, Natalie Curley, Sarah Curran, Helen Davies, Jana De Villiers, William Evans, Bernhard Frank, Alice Groves, Judith Hayward, Jon Higham, Dyfrig A. Hughes, Shwe Sin Kyaw, Anthony G. Marson, Ailsa McLellan, Seth Mensah, Francis O'Neill, Jane Sargison, Sanjay M. Sisodiya, Jill Swan, Joanna M. Zakrewska, Munir Pirmohamed   +24 more
wiley   +1 more source

How Soon Is Now? [PDF]

Biol Psychiatry Glob Open Sci
Arjmand S, Sellgren CM.
europepmc   +1 more source

The interplay between molecular architecture, pharmacology, and suspected adverse drug reactions associated with nonsteroidal androgen antagonists in the United Kingdom

British Journal of Clinical Pharmacology, EarlyView.
Aims This work aimed to correlate potential links between the suspected adverse drug reaction (ADR) profile of licensed nonsteroidal androgen receptor antagonists (NSARA) with their unique chemical properties and known off‐target polypharmacology. Methods Physicochemical and polypharmacology data were curated from the Electronic Medicines Compendium ...
Simrit Dhillon, Albert A. Antolin, Alan M. Jones   +2 more
wiley   +1 more source

DNA methylation signatures associated with bipolar disorder in peripheral blood improve prediction models. [PDF]

EBioMedicine
Tesfaye M, Stavrum AK, Höffler KD, O'Connell KS, David FS, Garrett ME, Hesam-Shariati S, Overs BJ, Pisanu C, Spano L, Watkeys OJ, Weihs A, Ardau R, Ashley-Koch AE, Athanasiu L, Beckham JC, Bourassa KJ, Chillotti C, Djurovic S, Drange OK, Frank J, Khayachi A, Kimbrel NA, Martorell L, Meinert S, Melle I, Morken G, Paribello P, Pinna M, Roberts G, Rouleau G, Schofield PR, Sepúlveda E, Severino G, Steen VM, Stein F, Streit F, VA Mid-Atlantic MIRECC Workgroup, Lagerberg TV, Alda M, Dannlowski U, Forstner AJ, Fullerton JM, Grabe HJ, Green MJ, Kircher T, Labad J, Manchia M, Mitchell PB, Soares JC, Squassina A, Teumer A, Tondo L, Vilella E, Andreassen OA, Chaumette B, Fries GR, Le Hellard S.   +57 more
europepmc   +1 more source

ACKR1/Duffy‐null genotype testing for clozapine: A guideline developed by the UK Centre of Excellence in Regulatory Science and Innovation in Pharmacogenomics (CERSI‐PGx)

British Journal of Clinical Pharmacology, EarlyView.
Abstract Clozapine is licenced for treatment‐resistant schizophrenia and psychosis in Parkinson's disease. In the United Kingdom, there is a mandatory requirement for absolute neutrophil count (ANC) and white blood cell count (WBC) monitoring to safeguard against agranulocytosis.
Stephen Murtough, Oriella Stellakis, Daisy Mills, Blanca Bjourson, Vicky Chaplin, Dharmisha Chauhan, Bev Chipp, Marius Cotic, Jana de Villiers, Olubanké Dzahini, Frances Elmslie, Katie Evans, Shreyans Gandhi, Dyfrig A. Hughes, Huajie Jin, Daniele Panconesi, Anna Skowronska, Sanjay M. Sisodiya, Ed Silva, Vicky Stinton, Sara Stuart‐Smith, Sarah Tarrant, David Taylor, Lauren Varney, James T. R. Walters, Michelle Wood, Jessica Woodley, Cinzia Dello Russo, Munir Pirmohamed, Elvira Bramon   +29 more
wiley   +1 more source

Mental Illness: A Deviation from Phenomenological, Rather than Moral, Norms? [PDF]

J Med Philos
Downey A.
europepmc   +1 more source

Teacher confidence and student engagement with mental health and wellbeing lessons: Learning from an iterative curriculum intervention in schools

British Educational Research Journal, EarlyView.
Abstract The mental health and wellbeing of young people has received increasing attention in both research and the wider public discourse. There has been a marked rise in mental health conditions in young people, and the burden of care is increasingly transferred onto schools and teachers.
Thomas Godfrey‐Faussett, Naomi French, Abbie Simpkin, Julian Turner, Tracey Riseborough, Natalie Coles, Ian Thompson   +6 more
wiley   +1 more source

Value drivers and barriers to the adoption of Precision Psychiatry in Latin America: a qualitative study. [PDF]

BMC Psychiatry
Quijano M, Rocha JV, Felton H, Ramírez-Bermúdez J, Correa H, Jaramillo CL, Serretti A, Vieta E.   +7 more
europepmc   +1 more source

Serotonin 5‐HT7 receptor signaling in neuropsychiatric disorders

Bulletin of the Korean Chemical Society, EarlyView.
5‐HT7R recruits Gs, G12, and β‐arrestin signaling to regulate neuronal plasticity, circuit function, and kinase‐linked intracellular responses. This review summarizes how these pathway‐selective modules contribute to autism spectrum disorder, depression, and schizophrenia, highlighting 5‐HT7R as a pathway‐informed therapeutic target. Abstract Serotonin
Eunseo Park, Hyunah Choo
wiley   +1 more source