Results 241 to 250 of about 3,239,321 (318)

Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Food Effect of Bexicaserin in Healthy Participants: A First‐in‐Human Randomized, Double‐Blind, Placebo‐Controlled Single Ascending Dose Escalation Phase 1 Study

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Bexicaserin (LP352) is a selective 5‐hydroxytryptamine 2C (5‐HT2C) superagonist in development for the treatment of seizures in developmental and epileptic encephalopathies (DEEs). This double‐blind, placebo‐controlled, single ascending dose (SAD) Phase 1 study aimed to assess the safety, tolerability, and pharmacokinetic (PK) and ...
Rosa Chan, Chad Orevillo, Gale O'Connell, Dewey McLin, Shikha Polega, Nuggehally R Srinivas, Randall Kaye   +6 more
wiley   +1 more source

Clinical Trials With Pragmatic Elements: A Review of Use Cases and Real‐World Data Utilization

Clinical Pharmacology &Therapeutics, EarlyView.
Clinical trials with pragmatic elements can capture diverse patient populations, enable efficient follow‐up, and reflect routine clinical practices; yet there is limited understanding of their design features, characteristics, and use of real‐world data (RWD). Based on a targeted search of PubMed/EMBASE (Jan‐2016 to Jul‐2024), a review was conducted to
Le Su, Lei Chen, Seema Betigeri, Nancy Dreyer, Helga Gardarsdottir, Rachele Hendricks‐Sturrup, Mehmet Burcu   +6 more
wiley   +1 more source

Hippocampal DNA Methylation Orchestrates Cortical Engram Maturation for Systems Consolidation of Memory. [PDF]

Biol Psychiatry
Snell CC, Gawf KE, Kitamura T.
europepmc   +1 more source

Infant Death due to Cannabis Ingestion

Drug Testing and Analysis, EarlyView.
ABSTRACT A child died in the emergency room of a local hospital a few hours after ingesting a substance the color of cork and the consistency of earth. At home, a modest amount of resinous substance was found. At the hospital, the child exhibited alterations in walking, balance, and consciousness.
Donata Favretto, Antonello Cirnelli, Roberto Pertile, Raffaella Stimamiglio, Clara Cestonaro, Oriana Cuman, Anna Pagliaro, Fabio Mattiazzi, Cristina Basso, Maddalena Galeazzi   +9 more
wiley   +1 more source

Considerations for informing precision psychiatry in eating disorders: Foundations for future practice. [PDF]

J Eat Disord
Obeid N, Lavallée N, Bradley AHM, Norris ML.   +3 more
europepmc   +1 more source

A head start: The relationship of placental factors to craniofacial and brain development

Developmental Dynamics, EarlyView.
Abstract In recent years, the importance of placental function for fetal neurodevelopment has become increasingly studied. This field, known as neuroplacentology, has greatly expanded possible etiologies of neurodevelopmental disorders by exploring the influence of placental function on brain development.
Annemarie Jenna Carver, Martine Dunnwald, Hanna Elizabeth Stevens   +2 more
wiley   +1 more source

Artificial Intelligence in Psychiatry: A Review of Biological and Behavioral Data Analyses

Ismail BAYDİLİ, Burak Taşçı, Gülay Taşçı   +2 more
openalex   +1 more source

Precision psychiatry roadmap: towards a biology-informed framework for mental disorders. [PDF]

Mol Psychiatry
Kas MJH, Penninx BWJH, Knudsen GM, Cuthbert B, Falkai P, Sachs GS, Ressler KJ, Bałkowiec-Iskra E, Butlen-Ducuing F, Leboyer M, Marston H, Luthman J, Mantua V.   +12 more
europepmc   +1 more source