Results 121 to 130 of about 702,953 (323)

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

FEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao, Qiangbing Yang, Christian J.B. Snijders Blok, Mark A. Daniels, Pieter A. Doevendans, Raymond Schiffelers, Joost P.G. Sluijter, Zhiyong Lei   +7 more
wiley   +1 more source

Identifying network communities with a high resolution

, 2007
Community structure is an important property of complex networks. An automatic discovery of such structure is a fundamental task in many disciplines, including sociology, biology, engineering, and computer science.
A. Y. Ng, C. Elkan, D. Hand, G. W. Flake, J. Ruan, J. Ruan, Jianhua Ruan, L. Danon, L. Danon, P. N. Tan, P. O. Fjällström, S. White, Weixiong Zhang   +12 more
core   +1 more source

Education for sexuality - faces and interfaces in teacher education: description and results of the offer of the discipline for the degree course in biological sciences

, 2022
Discutir temas relacionados con la sexualidad se ha convertido en un desafío para los docentes, por lo que es importante formar docentes preparados para orientar y discutir en el aula los múltiples aspectos relacionados con la sexualidad humana. Este trabajo consiste en relatar las características (horarios, menú, objetivos y estrategias) de la ...
Fernandes, Sheila Silveira, Assis, Vitória Costa de, Acrani, Simone   +2 more
openaire   +1 more source

Nanobotany: An Important Line of Research for Botanists

International Journal of Economic Plants, 2015
Nanotechnology has opened many new avenues for the researchers in various fields of science and technology. In biological sciences, it has widened scope for scientists and researchers and a number of applications have been invented. Significant research
Ratikanta Maiti, Ashok K. Thakur, N. C. Sarkar   +2 more
doaj  

Review of Statistical Learning Methods in Integrated Omics Studies (An Integrated Information Science)

Bioinformatics and Biology Insights, 2018
Integrated omics is becoming a new channel for investigating the complex molecular system in modern biological science and sets a foundation for systematic learning for precision medicine. The statistical/machine learning methods that have emerged in the
Irene Zeng, T. Lumley
semanticscholar   +1 more source

Intron‐oriented HTLV‐1 integration in an adult T‐cell leukemia/lymphoma cell line sustains expression of intact ift81 mRNA

FEBS Letters, EarlyView.
In the adult T‐cell leukemia/lymphoma (ATL) cell line ED, the human T‐cell leukemia virus type 1 (HTLV‐1) provirus was integrated into the intron of the ift81 gene in the antisense orientation. Despite this integration, both the intact ift81 and the viral oncogene hbz were simultaneously expressed, likely due to the functional insufficiency of viral ...
Mayuko Yagi, Yuka Hirosawa, Yusaku Sagisaka, Minami Hama, Satoshi Takeda, Jun A. Komano   +5 more
wiley   +1 more source

How was it for you? A cross-disciplinary study of ‘troublesome knowledge’ as identified by undergraduate students and lecturers in Geography, Medical Science and Psychology [PDF]

, 2011
We carried out a small scale pilot study to determine whether participants would spontaneously identify Threshold Concepts (TC’s) and/or troublesome knowledge during open questioning on the characteristics of their disciplines.
Jamieson, Susan, MacAndrew, Siobhan B. G., Spedding, Nicholas   +2 more
core  

Cyclic nucleotide signaling as a drug target in retinitis pigmentosa

FEBS Letters, EarlyView.
Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää, Ahmed B. Montaser, Henri Leinonen   +2 more
wiley   +1 more source

TRAF2 binds to TIFA via a novel motif and contributes to its autophagic degradation

FEBS Letters, EarlyView.
TRAF family members couple receptor signalling complexes to downstream outputs, but how they interact with these complexes is not always clear. Here, we show that during ADP‐heptose signalling, TRAF2 binding to TIFA requires two short sequence motifs in the C‐terminal tail of TIFA, which are distinct from the TRAF6 binding motif.
Tom Snelling, Kodi Hunter, Celest W. S. Tay, Nicola T. Wood, Philip Cohen   +4 more
wiley   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source