Results 121 to 130 of about 396,040 (290)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Meat Animal Biologics Discovery Opportunities from the Gut Microbiome: Application of Metabolomics

Meat and Muscle Biology
Metabolomics is a high-throughput technology that is widely used across disciplines to identify and quantify metabolites in biological samples; however, its use has been limited in meat and animal science.
Chamia C Chatman, Elena Olson, Erica L-W Majumder, Hilario C Mantovani, Steven C Ricke   +4 more
doaj   +2 more sources

Cellular Automata Applications in Shortest Path Problem

, 2017
Cellular Automata (CAs) are computational models that can capture the essential features of systems in which global behavior emerges from the collective effect of simple components, which interact locally.
A Macwan, A Nash, AI Adamatzky, Anastasios Tsiftsis, C Nieto-Granda, C. Hochberger, C. Y. Lee, Christian Hochberger, D Ferguson, DB Johnson, EW Dijkstra, Fabio M. Marchese, G Ch Sirakoulis, G Ch Sirakoulis, George S. Fishman, H Beigy, Hong Qu, Ioakeim G. Georgoudas, J Li, J Neumann Von, J-H Liang, K Nagel, K. Ioannidis, Konstantinos Ioannidis, Lazaros Nalpantidis, M Defoort, M.A. Porta Garcia, M.G. Kechaidou, Michail-Antisthenis I Tsompanas, Michail-Antisthenis I. Tsompanas, Michail-Antisthenis I. Tsompanas, Michail-Antisthenis I. Tsompanas, Michail-Antisthenis I. Tsompanas, Michail-Antisthenis I. Tsompanas, Nikolaos Dourvas, Nikolaos I. Dourvas, Nikolaos I. Dourvas, O Montiel, PG Tzionas, Q Sun, RW Floyd, S Liu, S Warshall, SK Moghaddam, T Nakagaki, Tiago P. Nascimento, Usman Ahmed Syed, V.S. Kalogeiton, Vasileios G. Ntinas, Vasilis Evangelidis, Vassilios A. Mardiris, Vicky S. Kalogeiton, X Zhang, XGM Wang, XJ Wu, Y Wang   +55 more
core   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

The dangerous biology of pathogenic germs

Comptes Rendus Biologies
The convergence of biotechnologies with other disciplines, including computer science and Artificial Intelligence (AI), may make it possible to carry out dangerous genetic manipulations on pathogenic germs, as the gain-of-function experiments ...
Berche, Patrick
doaj   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

What we can freeze from the body and why : a historical, physical, and mathematical introduction [abstract] [PDF]

, 2008
This presentation was made during the session "After the Body: Is It Still Human?"Abstract of a presentation given at the 2008 Body Project conference at the University of Missouri-Columbia.The public often links cryobiology, the study of biological ...
Benson, James
core  

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Varieties of Exploratory Experimentation in Nanotoxicology [PDF]

, 2008
There has been relatively little effort to provide a systematic overview of different forms of exploratory experimentation (EE). The present paper examines the growing subdiscipline of nanotoxicology and suggests that it illustrates at least four ways ...
Elliott, Kevin
core