Results 141 to 150 of about 702,953 (323)

Meat Animal Biologics Discovery Opportunities from the Gut Microbiome: Application of Metabolomics

Meat and Muscle Biology
Metabolomics is a high-throughput technology that is widely used across disciplines to identify and quantify metabolites in biological samples; however, its use has been limited in meat and animal science.
Chamia C Chatman, Elena Olson, Erica L-W Majumder, Hilario C Mantovani, Steven C Ricke   +4 more
doaj   +2 more sources

Redox‐dependent binding and conformational equilibria govern the fluorescence decay of NAD(P)H in living cells

FEBS Letters, EarlyView.
In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker, Nimit Mistry, Nicoletta Plotegher, Elizabeth R. Westbrook, Michael D. E. Sewell, John Carroll, Gyorgy Szabadkai, Angus J. Bain, Michael R. Duchen   +8 more
wiley   +1 more source

The dangerous biology of pathogenic germs

Comptes Rendus Biologies
The convergence of biotechnologies with other disciplines, including computer science and Artificial Intelligence (AI), may make it possible to carry out dangerous genetic manipulations on pathogenic germs, as the gain-of-function experiments ...
Berche, Patrick
doaj   +1 more source

Neutrophil deficiency increases T cell numbers at the site of tissue injury in mice

FEBS Letters, EarlyView.
In wild‐type mice, injury or acute inflammation induces neutrophil influx followed by macrophage accumulation. Mcl1ΔMyelo (neutrophil‐deficient) mice lack neutrophils, and in response to muscle injury show fewer macrophages and exhibit strikingly elevated T‐cell numbers, primarily non‐conventional “double‐negative” (DN) αβ and γδ T cells.
Hajnalka Halász, Albert Bálint Papp, Lukács Sándor Lesinszki, Attila Mócsai, Tamás Varga, László Nagy, Péter Gogolák   +6 more
wiley   +1 more source

Functional role and folding properties of the glucan‐binding domain of oral bacterial glucansucrase

FEBS Letters, EarlyView.
The role of the glucan‐binding domain in Streptococcus sobrinus glucansucrase was examined, focusing on its impact on enzymatic activity, dextran binding, and structural stability of deletion mutants and a circularly permuted protein. Our research revealed that glucosyl transfer efficiency is linked to cooperative interdomain folding.
Hideyuki Komatsu, Takayuki Sadakane, Yudai Murata, Junichi Taira, Hiroshi Sakamoto, Takao Kodama   +5 more
wiley   +1 more source

Lesson Plan Proposal on Molecular Paleontology for insertion in the discipline of Paleontology of undergraduate courses in Biological Sciences

Molecular Paleontology has not been included in the syllabus of the discipline of Paleontology in undergraduate courses in Biological Sciences. However, if inserted in the discipline's Teaching Plan, Molecular Paleontology could bring future biologists closer to Paleobiology, a field of research that is practically unexplored in Brazil.
openaire   +1 more source

Preparing for a Northwest Passage: A Workshop on the Role of New England in Navigating the New Arctic [PDF]

, 2018
Preparing for a Northwest Passage: A Workshop on the Role of New England in Navigating the New Arctic (March 25 - 27, 2018 -- The University of New Hampshire) paired two of NSF\u27s 10 Big Ideas: Navigating the New Arctic and Growing Convergence ...
Ashcraft, Catherine M, Brewer, Jennifer F, Burakowski, Elizabeth, Coffin, Jaed M, Dibb, Jack E, Duderstadt, Katharine A, Hamilton, Lawrence C, Kinner, Nancy E, Mayer, Larry A., Miksis-Olds, Jennifer L, Salisbury, Joseph, Seger, Kerri D, Varner, Ruth K., Wake, Cameron P.   +13 more
core   +1 more source

The cytochrome oxidase defect in ISC‐depleted yeast is caused by impaired iron–sulfur cluster maturation of the mitoribosome assembly factor Rsm22

FEBS Letters, EarlyView.
The yeast mitoribosome assembly factor Rsm22 contains a [4Fe‐4S] cluster that is matured by the mitochondrial iron–sulfur cluster assembly (ISC) machinery. Defects in ISC components result in impaired mitochondrial protein synthesis due to a mitoribosome assembly defect.
Ulrich Mühlenhoff, Dominik Trauth, Weronika Śliwińska, Linda Boss, Roland Lill   +4 more
wiley   +1 more source

Development of visible light‐sensitive human neuropsin (OPN5) via single amino acid substitution

FEBS Letters, EarlyView.
The present study determines a key amino acid residue, Lys91, for defining UV sensitivity of human OPN5. Heterologous action spectroscopy of the wild type and K91 mutants of OPN5 in HEK293T cells reveals that substitution of Lys91 with neutral (alanine) or acidic amino acids (glutamic or aspartic acids) causes substantial shifts in spectral sensitivity
Yusuke Sakai, Richard J. McDowell, Robert J. Lucas   +2 more
wiley   +1 more source

Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells

FEBS Letters, EarlyView.
Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan, Victoria Scarpelli, Marten Exterkate   +2 more
wiley   +1 more source