Results 221 to 230 of about 702,953 (323)

Unifying social science: a critical realist approach [PDF]

, 2005
Holland, D
core  

Pursuing Darwin’s curious parallel: Prospects for a science of cultural evolution

Proceedings of the National Academy of Sciences of the United States of America, 2017
A. Mesoudi
semanticscholar   +1 more source

Association of high‐dose radioactive iodine therapy with PPM1D‐mutated clonal hematopoiesis in older individuals

Molecular Oncology, EarlyView.
In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim, Sungwoo Bae, Jaeyong Choi, Sun‐Wha Im, Bukyoung Cha, Gyeongseo Jung, Sun Wook Cho, Eul‐Ju Seo, Young Ah Lee, Jin Chul Paeng, Young Joo Park, Jong‐Il Kim   +11 more
wiley   +1 more source

Expression and application of a novel Holin Hol6A3 in phage PD6A3 of Acinetobacter baumannii. [PDF]

BMC Microbiol
Wu M, Yang Y, Wang H, Wang B, Pan B, Xie Y, Guo W.   +6 more
europepmc   +1 more source

Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management

Molecular Oncology, EarlyView.
DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez, Asieh Naderi, Kim‐Tuyen Huynh‐Dam, Vitali Sikirzhytski, Ioulia Chatzistamou, Hippokratis Kiaris   +5 more
wiley   +1 more source

Opening doors to physical sample tracking and attribution in Earth and environmental sciences. [PDF]

Sci Data
Damerow JE, Raia NH, Stanley V, Choe S, Borton MA, Byers N, Cassidy ER, Cholia S, Edmunds R, Forbes B, Forrest K, Goldman AE, Kunze J, Lafia S, Lehnert K, McIntyre-Redden M, Naples R, O'Ryan D, Parker C, Plomp E, Powers-McCormack B, Ramdeen S, Richard S, Thessen A, Thompson CW, Vieglais D, Vrouwenvelder K, Wood-Charlson EM, Wyborn L, Reddy TBK, Thomer AK.   +30 more
europepmc   +1 more source

ITGAV and SMAD4 influence the progression and clinical outcome of pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
In SMAD4‐positive pancreatic ductal adenocarcinoma (PDAC), integrin subunit alpha V (ITGAV) activates latent TGF‐β, which binds to the TGF‐β receptor and phosphorylates SMAD2/3. The activated SMAD2/3 forms a complex with SMAD4, and together they translocate to the nucleus, modulating gene expression to promote proliferation, migration, and invasion. In
Daniel K. C. Lee, Keyue Chen, Ryan Loke, Xiang Li, David Liubart, Golam T. Saffi, Jonathan T. S. Chow, Ché M. P. Melo, Lydia To, Leonardo Salmena   +9 more
wiley   +1 more source

What Is Social Connection in the Context of Human Need: An Interdisciplinary Literature Review. [PDF]

Int J Environ Res Public Health
Bauer KL, Johnson-Koenke R, Fort MP.
europepmc   +1 more source

Raphin‐1 mediates the survival and sensitivity to radiation of pediatric‐type diffuse high‐grade glioma via phosphorylated eukaryotic initiation factor 2α‐dependent and ‐independent processes

Molecular Oncology, EarlyView.
Raphin‐1 reduces the survival of PED‐DHGG cells and enhances their radiation sensitivity through both PeIF2α‐dependent and PeIF2α‐independent mechanisms. Raphin‐1 sustains elevated levels of PeIF2α, contributing to its PeIF2α‐dependent effects. Additionally, raphin‐1 interacts with CReP to mediate a separate radiosensitizing pathway that operates ...
Karin Eytan, Moshe Leitner, Amos Toren, Shoshana Paglin, Michal Yalon   +4 more
wiley   +1 more source

A moonshot for female astronaut health, a win for all astronauts and space exploration. [PDF]

NPJ Microgravity
Farrell RM, Fogarty JA, Covington M, Van Baalen M, Aunon-Chancellor S, Steller JG.   +5 more
europepmc   +1 more source