Results 61 to 70 of about 56,785 (248)

Towards a New Science of Information

tripleC: Communication, Capitalism & Critique, 2011
This paper suggests a New Information Paradigm and recommends the establishment of a new academic and scientific discipline to be titled "Science of Information", built on a premise that information is also a major part of all the universes, elements ...
Dail Dewitt Doucette
doaj   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Fog in western coastal ecosystems: inter-disciplinary challenges and opportunities with example concepts from the Pacific Northwest, USA

Frontiers in Environmental Science
Coastal fog occurs along many of the world’s west coast continental environments. It is particularly consequential during summer when an increased frequency of fog co-occurs with the seasonal dryness characteristic of most west coast climate systems, for
Alex Dye, Sonya Rauschenbach, Sonya Rauschenbach, Simon de Szoeke, Adele L. Igel, Yufang Jin, John B. Kim, Meg A. Krawchuk, Kenneth Maes, Larry O’Neill, Kyaw Tha Paw U, Roger Samelson, David C. Shaw, Christopher Still   +13 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Paraneoplastic Lupus Nephritis in a Child With Neuroblastoma Recurrence

Pediatric Blood &Cancer, EarlyView.
Gabriele Mortari, Caterina Costagliola, Marta Nebiolo, Francesca Parisi, Martina Morini, Katia Mazzocco, Gabriele Gaggero, Stefano Volpi, Stefania Sorrentino, Virginia Livellara   +9 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Uncovering Patterns and Trends in Big Data-Driven Research Through Text Mining of NSF Award Synopses

Analytics
The rapid expansion of big data has transformed research practices across disciplines, yet disparities exist in its adoption among U.S. institutions of higher education.
Arielle King, Sayed A. Mostafa
doaj   +1 more source

Education for sexuality - faces and interfaces in teacher education: description and results of the offer of the discipline for the degree course in biological sciences

, 2022
Discutir temas relacionados con la sexualidad se ha convertido en un desafío para los docentes, por lo que es importante formar docentes preparados para orientar y discutir en el aula los múltiples aspectos relacionados con la sexualidad humana. Este trabajo consiste en relatar las características (horarios, menú, objetivos y estrategias) de la ...
Fernandes, Sheila Silveira, Assis, Vitória Costa de, Acrani, Simone   +2 more
openaire   +1 more source

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source