Results 131 to 140 of about 833,851 (294)
iScience, 2021 Summary: Single-molecule localization microscopy (SMLM) reports on protein organization in cells with near-molecular resolution and in combination with stoichiometric labeling enables protein counting.
Tim N. Baldering +8 more
doaj
Invention, Innovation, and Commercialisation in British Biophysics [PDF]
arXivBritish biophysics has a rich tradition of scientific invention and innovation, on several occasions resulting in new technologies which have transformed biological insight, such as rapid DNA sequencing, high-precision super-resolution and label-free microscopy hardware, new approaches for high-throughput and single-molecule bio-sensing, and the ...
arxiv
Molecular Oncology, EarlyView.Patient engagement involves actively including patients in healthcare decisions and research to ensure care and studies align with their needs. This approach improves outcomes, trust, and communication while fostering collaboration between patients and professionals.
Estela Cepeda +3 more
wiley +1 more source
Automating Exploratory Proteomics Research via Language Models [PDF]
arXivWith the development of artificial intelligence, its contribution to science is evolving from simulating a complex problem to automating entire research processes and producing novel discoveries. Achieving this advancement requires both specialized general models grounded in real-world scientific data and iterative, exploratory frameworks that mirror ...
arxiv
An Extension of Deep Pathway Analysis: A Pathway Route Analysis Framework Incorporating Multi-dimensional Cancer Genomics Data [PDF]
arXiv, 2017 Recent breakthroughs in cancer research have come via the up-and-coming field of pathway analysis. By applying statistical methods to prior known gene and protein regulatory information, pathway analysis provides a meaningful way to interpret genomic data.
arxiv
Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM
Molecular Oncology, EarlyView.CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak +14 more
wiley +1 more source
PCR-based profiling of transcription factor activity in vivo by a virus-based reporter battery
iScience, 2022 Summary: Understanding the molecular mechanisms of gene regulation is pivotal for understanding how cells establish and modify their identities and functions.
Hitomi Abe, Kentaro Abe
doaj
Molecular Oncology, EarlyView.This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini +10 more
wiley +1 more source
Strengthening the Scientific Foundations of Professional Psychology: Time for the Next Steps [PDF]
, 2007 The field of professional psychology has been tremendously successful, although it has also been characterized by many competing preparadigmatic theoretical orientations, which have led to a great deal of contention as well as conflicting views regarding
Melchert, Timothy
core +1 more source
iScience, 2021 Summary: The mouse eye is used to model central nervous system development, pathology, angiogenesis, tumorigenesis, and regenerative therapies. To facilitate the analysis of these processes, we developed an optimized tissue clearing and depigmentation ...
Akshay Gurdita +13 more
doaj