Results 171 to 180 of about 44,994 (269)

Law 2287 of 2023 on biobanks in Colombia: A bioethical reflection on its scope [PDF]

open access: yesBiomedica
Vélez-Arango JM   +3 more
europepmc   +1 more source

The L108I polymorphism in mouse prion protein drives spontaneous disease and enhances transmission of atypical and classical prion strains

open access: yesBrain Pathology, EarlyView.
A single amino acid change (L108I) combined with PrP overexpression drives spontaneous atypical prion formation in mice, enabling also efficient propagation of diverse prion strains. This model allows studying how spontaneous prion diseases arise and provides powerful tools for investigating strain emergence, transmission barriers, and mechanisms ...
Hasier Eraña   +20 more
wiley   +1 more source

Systematics, natural history, and conservation of <i>Erica</i> (Ericaceae). [PDF]

open access: yesPhytoKeys
Pirie MD   +7 more
europepmc   +1 more source

IRF4 Enhances Radiosensitivity of Cervical Cancer by Inhibiting the PI3K/Akt/mTOR Pathway to Regulate Autophagy

open access: yesCancer Science, EarlyView.
IRF4 is a prognostic biomarker in cervical cancer. IRF4 enhances radiosensitivity and inhibits tumor growth via PI3K/AKT/mTOR‐mediated autophagy. IRF4 boosts radiation response in vitro and in vivo. ABSTRACT Interferon regulatory factor 4 (IRF4), a critical member of the IRF transcription factor family, harbors an elusive biological role in cervical ...
Meihui Gao   +9 more
wiley   +1 more source

Development of biobanking infrastructure in Armenia: opportunities and challenges. [PDF]

open access: yesFront Public Health
Mkrtchyan G   +6 more
europepmc   +1 more source

Expression of Glycoprotein B (gB) Correlates With Poor Prognosis in Nasopharyngeal Carcinoma

open access: yesCancer Science, EarlyView.
The extent of EBV lytic replication in NPC has not been fully clarified. Our study demonstrated EBV replication and release in NPC and identified a significant association between expression of the late lytic protein gB and poor prognosis. These findings suggest that late lytic gene products may contribute to tumor progression and that gB represents a ...
Shigetaka Komura   +24 more
wiley   +1 more source

CALR/HIF‐1α Positive Feedback Loop Drives CALR Upregulation to Promote EMT‐Mediated Bladder Cancer Progression via ROS/AKT Axis

open access: yesCancer Science, EarlyView.
This study first found that the high expression of CALR is due to a novel positive feedback loop with HIF‐1α in the tumor microenvironment: CALR stabilizes HIF‐1α protein, while HIF‐1α transcriptionally upregulates CALR expression, thereby self‐sustaining its high expression levels in BLCA.
Xintao Tian   +11 more
wiley   +1 more source

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