Results 61 to 70 of about 44,994 (269)

Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline Metabolism

Advanced Science, EarlyView.
The study demonstrated that connexin43 (Cx43) knockout caused arrhythmic phenotype and decreased proline content in vitro and in vivo. Mechanistically, Cx43 interacts with the amino acid transporter SNAT2 (sodium‐dependent neutral amino acid transporter), and its deficiency disrupts proline transport and metabolism.
Hangying Ying, Hangping Fan, Yunhe Wang, Ruhong Jiang, Dongsheng Cai, Hui Cheng, Hao Wang, Chenyang Jiang, Ping Liang   +8 more
wiley   +1 more source

Observations on the ecology and conservation status of Haloragis exalata subsp. exalata (Haloragaceae) in southern New South Wales [PDF]

, 2013
Haloragis exalata F. Muell. subspecies exalata (family Haloragaceae), a perennial forb, is currently listed as Vulnerable, under both national and New South Wales threatened species conservation legislation.
Cameron, Stuart, Miles, Jackie
core  

Green Plants in the Red: A Baseline Global Assessment for the IUCN Sampled Red List Index for Plants [PDF]

, 2015
Plants provide fundamental support systems for life on Earth and are the basis for all terrestrial ecosystems; a decline in plant diversity will be detrimental to all other groups of organisms including humans. Decline in plant diversity has been hard to
Albuquerque, S, Aletrari, E, Andrews, AK, Atchison, G, Bachman, SP, Baloch, E, Barlozzini, B, Brummitt, NA, Brunazzi, A, Carretero, J, Celesti, M, Chadburn, H, Cianfoni, E, Cockel, C, Coldwell, V, Concetti, B, Contu, S, Crook, V, Donaldson, JS, Dyson, P, Farjon, A, Gardiner, L, Ghanim, N, Greene, H, Griffiths-Lee, J, Groom, A, Harker, R, Hilton-Taylor, C, Hopkins, D, Khela, S, Lakeman-Fraser, P, Lindon, H, Lockwood, H, Loftus, C, Lombrici, D, Lopez-Poveda, L, Lutz, M, Lyon, J, Malcolm-Tompkins, P, McGregor, K, Meagher, TR, Moat, JF, Moreno, L, Murray, L, Nazar, K, Nic Lughadha, EM, Power, E, Quiton Tuijtelaars, M, Salter, R, Segrott, R, Thacker, H, Thomas, LJ, Tingvoll, S, Watkinson, G, Wojtaszekova, K   +54 more
core   +1 more source

A Protein‐Centric Strategy Coupled with Match‐Between‐Run Glycoproteomics Enables Discovery of Robust Site‐Specific Glycan Biomarkers for Hepatocellular Carcinoma

Advanced Science, EarlyView.
In this study, a highly robust N‐glycoproteomics (HRN) platform with a newly developed match‐between‐run scheme is used for biomarker discovery. This study proposes a protein‐centric strategy to prioritize proteins susceptible to aberrant glycosylation.
Lei Liu, Taiheng Ma, Qi Liu, He Zhu, Zheng Fang, Jiahong Ma, Ting Yu, Yan Wang, Jiahua Zhou, Xiaoyan Liu, Yaqian Li, Zhimou Guo, Xinmiao Liang, Mingming Dong, Deguang Sun, Mingliang Ye   +15 more
wiley   +1 more source

A study to examine the operation and function of a virtual UK environmental specimen bank (UK-ESB). Final report [PDF]

, 2012
Executive Summary: 1. Environmental specimen banking is recognised internationally as an integral part of long-term environmental research and monitoring. Analysis of preserved environmental samples is often needed to detect and quantify patterns and
Brown, M.J., Chaplow, J.S., Howard, D.C., Patel, S., Shore, R.F.   +4 more
core  

A Testis‐Specific Aralkylamine N‐Acetyltransferase Regulates Dimorphic Sperm Function and Male Fertility in Moths

Advanced Science, EarlyView.
We identify a Lepidoptera‐conserved testis‐specific arylalkylamine N‐acetyltransferase (LTNAT) that governs male moth fertility via a novel mechanism. LTNAT loss disrupts eupyrene sperm mitochondrial derivatives and impairs apyrene sperm motility, offering a safe molecular target for innovative pesticides and genetic pest control.
Hao Sun, Peng‐Yi Huang, Zhi‐Ruo Zhang, Cong‐Fen Gao, Subba Reddy Palli, Shun‐Fan Wu   +5 more
wiley   +1 more source

ETV4 Promotes Colorectal Cancer Progression by Reprogramming Asparagine Metabolism to Remodel the Stromal Microenvironment

Advanced Science, EarlyView.
ETV4 coordinates a dual transcriptional program by upregulating MET and asparagine synthetase (ASNS). The resulting asparagine (Asn) secretion acts as a metabolic signal, reprogramming hepatic stellate cells (HSCs) and primary cancer‐associated fibroblasts (CAFs) toward an inflammatory phenotype. These activated stromal cells release HGF to sustain the
Dujiang Fu, Meijia Zhang, Maoping Cai, Miao Wang, Ziao Huang, Zesheng Lin, Yixin Liu, Wang Qian, Guopeng Chen, Yuxing Liang, Dongyi Wei, Jing xie, Picheng Yan, Yuanyuan Qu, Yongchang Wei   +14 more
wiley   +1 more source

Freshwater Macroinvertebrates [PDF]

, 2003
The purpose of this resource is to sample, identify, and count macroinvertebrates at a Hydrology Site. Students collect, sort, identify, and count macroinvertebrates from habitats at their site.
The GLOBE Program, UCAR (University Corporation for Atmospheric Research)
core  

On the origin of Halipeurus heraldicus on Round Island petrels: cophylogenetic relationships between petrels and their chewing lice [PDF]

, 2010
Lice phylogenetic relationships have often been used to elucidate host relationships and vice versa. In this study, we investigate the louse genus Halipeurus which parasitizes bird hosts in the families Procellariidae, Hydrobatidae and Pelecanoididae ...
Brown, R., Bugoni, L., Hammer, S., Hughes, J., Palma, R.L.   +4 more
core   +1 more source

Humanized and Charge‐Optimized CSPG4‐Specific CAR‐T Cells show Enhanced Efficacy against Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
CSPG4 is identified as a high‐value, stemness‐associated target in HPV‐negative HNSCC. By implementing rational biophysical engineering, a humanized and charge‐optimized CAR is developed to overcome tonic signaling‐induced exhaustion. This strategy induces a profound transcriptomic shift toward a rejuvenated, stem‐like memory state, significantly ...
Xiang Xu, Shizhen Qiu, Zhitong Wang, Dan Li, Min Chen, Yinying Chu, Guangfei Li, Yi Fang, Changjiang Li, Fang Shi, Peijie He, Haitao Wu, Haopeng Wang, Jian Chen   +13 more
wiley   +1 more source