Results 61 to 70 of about 45,213 (265)

Myeloid‐Derived Grancalcin Promotes Periodontal Inflammation and Pathological Bone Remodeling in Periodontitis

Advanced Science, EarlyView.
Grancalcin (GCA), a myeloid‐derived protein, is enriched in gingival tissues of periodontitis patients and mouse models. Through interactions with CD44 and activation of MYH9, GCA promotes NF‐κB signaling and exacerbates periodontal inflammation and bone loss.
Min Zhou, Yao Xiao, Ziyue Xu, Chengyu Yang, Jiang Li, Ya Liu, Ping Yin   +6 more
wiley   +1 more source

Green Plants in the Red: A Baseline Global Assessment for the IUCN Sampled Red List Index for Plants [PDF]

, 2015
Plants provide fundamental support systems for life on Earth and are the basis for all terrestrial ecosystems; a decline in plant diversity will be detrimental to all other groups of organisms including humans. Decline in plant diversity has been hard to
Albuquerque, S, Aletrari, E, Andrews, AK, Atchison, G, Bachman, SP, Baloch, E, Barlozzini, B, Brummitt, NA, Brunazzi, A, Carretero, J, Celesti, M, Chadburn, H, Cianfoni, E, Cockel, C, Coldwell, V, Concetti, B, Contu, S, Crook, V, Donaldson, JS, Dyson, P, Farjon, A, Gardiner, L, Ghanim, N, Greene, H, Griffiths-Lee, J, Groom, A, Harker, R, Hilton-Taylor, C, Hopkins, D, Khela, S, Lakeman-Fraser, P, Lindon, H, Lockwood, H, Loftus, C, Lombrici, D, Lopez-Poveda, L, Lutz, M, Lyon, J, Malcolm-Tompkins, P, McGregor, K, Meagher, TR, Moat, JF, Moreno, L, Murray, L, Nazar, K, Nic Lughadha, EM, Power, E, Quiton Tuijtelaars, M, Salter, R, Segrott, R, Thacker, H, Thomas, LJ, Tingvoll, S, Watkinson, G, Wojtaszekova, K   +54 more
core   +1 more source

Humanized and Charge‐Optimized CSPG4‐Specific CAR‐T Cells show Enhanced Efficacy against Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
CSPG4 is identified as a high‐value, stemness‐associated target in HPV‐negative HNSCC. By implementing rational biophysical engineering, a humanized and charge‐optimized CAR is developed to overcome tonic signaling‐induced exhaustion. This strategy induces a profound transcriptomic shift toward a rejuvenated, stem‐like memory state, significantly ...
Xiang Xu, Shizhen Qiu, Zhitong Wang, Dan Li, Min Chen, Yinying Chu, Guangfei Li, Yi Fang, Changjiang Li, Fang Shi, Peijie He, Haitao Wu, Haopeng Wang, Jian Chen   +13 more
wiley   +1 more source

The impact of one-decade ecological disturbance on genetic changes : a study on the brine shrimp Artemia urmiana from Urmia Lake, Iran [PDF]

, 2019
Urmia Lake, the largest natural habitat of the brine shrimp Artemia urmiana, has progressively desiccated over the last two decades, resulting in a loss of 80% of its surface area and producing thousands of hectares of arid salty land.
Asem, Alireza, Eimanifar, Amin, Sun, Shi-Chun, Van Stappen, Gilbert   +3 more
core   +1 more source

Inhibition of SIRT7 Overcomes Radioresistance in Pancreatic Neuroendocrine Tumors by Reactivating MEN1 Expression

Advanced Science, EarlyView.
Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang, Yan Wang, Yi Qin, Luohai Chen, Xiaowu Xu, Guixiong Fan, Desheng Jing, Miaoyan Wei, Xianjun Yu, Junfeng Xu, Shunrong Ji, Jie Chen   +11 more
wiley   +1 more source

Genome sequencing of the extinct Eurasian wild aurochs, Bos primigenius, illuminates the phylogeography and evolution of cattle [PDF]

, 2015
Background Domestication of the now-extinct wild aurochs, Bos primigenius, gave rise to the two major domestic extant cattle taxa, B. taurus and B. indicus.
A Achilli, A Achilli, A Esteve-Codina, A Gotherstrom, A Seguin-Orlando, A Vaysse, A Winter, AE Minoche, AJ Amaral, Alison Murphy, Amanda J. Lohan, Andrew T. Chamberlain, AV Zimin, B Grisart, B Grisart, BP Lewis, Brendan J. Loftus, C Gamba, C Glaser, Ceiridwen J. Edwards, CG Elsik, Charles Spillane, CJ Edwards, CJ Edwards, CJ Edwards, CJ Rubin, CJ Stevens, CM Leu, CS Troy, D Reich, Daniel G. Bradley, David A. Magee, David E. MacHugh, DE MacHugh, DG Bradley, DM Larkin, DP Toews, E Palkopoulou, E Svensson, EJ McTavish, EY Durand, H Jonsson, H Jonsson, H Li, H Zhang, HD Daetwyler, J Clutton-Brock, J Diamond, J Kantanen, J Lenstra, J Schibler, JA Guerra-Assuncao, JD Vigne, JE Decker, JK Pickrell, JK Pritchard, JS Pedersen, K Prufer, KA Moutou, Kévin Rue-Albrecht, L Orlando, L Perez-Pardal, LK Matukumalli, M Gautier, M Hofreiter, M Li, M Meyer, M Raghavan, M Rasmussen, M Schubert, MA DePristo, MA Greagg, MA Groenen, Mark T. Donoghue, Martin Braud, Matthew D. Teasdale, MJ Montague, N Murakami, N Patterson, NA Rosenberg, O Smith, Paul A. McGettigan, R Bollongino, R Chen, RA Gibbs, RE Green, RE Green, RH Meadow, RR Hudson, RT Loftus, S Bonfiglio, S Bonfiglio, S Bonfiglio, S Guindon, S Koks, S Paabo, S Qanbari, S Sawyer, Shuaishuai Tai, Stephen D E Park, Steven Schroeder, Tad S. Sonstegard, TH Lee, W McLaren, Y Benjamini, Yuan Liu   +105 more
core   +1 more source

Androgen Receptor‐Induced Lactoferrin Accelerates Prostate Tumorigenesis Through Modulating Ferroptosis

Advanced Science, EarlyView.
This study demonstrates that transcription factor androgen receptor (AR) directly binds the LF promoter, driving lactoferrin overexpression to promote ferritin (FTH1/FTL) upregulation and inhibit p53‐ALOX12‐mediated ferroptosis in prostate cancer. Lactoferrin could be a new potential therapeutic target in prostate cancer.
Can Liu, Qiu Peng, Xiaoyue Zhang, Zhengshuo Li, Yangge Wu, Yuqing Wen, Run Zheng, Shuanglong Wu, Chenfei Zhou, Zhengyu Hu, Lanjun Shu, Xinyi Ma, Qiuyang Li, Ya Ma, Chunlin Ou, Ming Zhao, Songqing Fan, Lingyu Wei, Jian Ma   +18 more
wiley   +1 more source

Genetic predisposition to porto‐sinusoidal vascular disorder: A functional genomic‐based, multigenerational family study

Hepatology, EarlyView., 2022
A deleterious variant of FCHSD1 results in mTOR pathway overactivation and may cause porto‐sinusoidal vascular disorder (PSVD). The pedigree of the family demonstrated an autosomal dominant disease with variable expressivity. Whole‐genome sequencing and Sanger sequencing both validated the existence of the FCHSD1 variant and the heterozygosity of c ...
Jingxuan Shan, André Megarbane, Aziz Chouchane, Deepak Karthik, Ramzi Temanni, Atilio Reyes Romero, Huiying Hua, Chun Pan, Xixi Chen, Murugan Subramanian, Chadi Saad, Hamdi Mbarek, Cybel Mehawej, Eliane Chouery, Sirin W. Abuaqel, Alexander Dömling, Sami Remadi, Cesar Yaghi, Pu Li, Lotfi Chouchane   +19 more
wiley   +1 more source

Species-specific Real Time-PCR primers/probe systems to identify fish parasites of the genera Anisakis, Pseudoterranova and Hysterothylacium (Nematoda: Ascaridoidea) [PDF]

, 2018
Ascaridoid nematodes belonging to the genera Anisakis and Pseudoterranova are heteroxenous parasites, involving marine mammals as definitive hosts in their life-cycles, whereas crustaceans (krill), fish and squids acting as intermediate/paratenic hosts.
Colantoni, Alessandra, Gay, Melanie, Levsen, Arne, Mattiucci, Simonetta, Nascetti, Giuseppe, Paoletti, Michela   +5 more
core   +1 more source

Molecular Glue cc‐885 Inhibits VHL‐Deficient Clear Cell Renal Cell Carcinoma via ETS1 Degradation

Advanced Science, EarlyView.
VHL‐deficient kidney cancer lacks effective treatments. This study reveals that the molecular glue degrader cc‐885 hijacks the cellular recycling system to selectively destroy the oncogenic protein ETS1, effectively killing VHL‐mutant tumors. Combining CC‐885 with the approved drug belzutifan achieves powerful synergy, offering a promising new ...
Taowei Yang, Qihao Li, Kun Ye, Kezhi Liu, Mi Zhou, Minyu Chen, Lican Liao, Kangbo Huang, Zhu Wang, Qiong Deng, Jieyan Wang, Meiyu Jin, Xu Chen, Hui Liang, Jiaxing Zhang, Junhang Luo   +15 more
wiley   +1 more source