Results 81 to 90 of about 44,994 (269)

BZW1 Drives Immune Evasion in Lung Adenocarcinoma via Ferroptosis Suppression

Advanced Science, EarlyView.
BZW1 attenuates ferroptosis by competitively binding NCOA4 and suppress ferrtinophagy‐mediated iron release. The depletion of BZW1 triggers lipid peroxidation through iron homeostasis. Extracellularly, BZW1 attenuates immunogenic cell death and reinvigorates cytotoxic T‐cell responses.
Linyao Zhao, Yue Peng, Qing Liang, Shi Liu, Yang Li, Lei Ma, Menghan Hu, Sujuan Zheng, Zhihua Liu, Shugeng Gao   +9 more
wiley   +1 more source

CircRSU1 Activates the hnRNPA1/HIF‐1α/CD24 Signaling Axis, Promoting Stemness Features of Hepatocellular Carcinoma

Advanced Science, EarlyView.
This study reveals circRSU1 with important oncogenic roles in hepatocellular carcinoma (HCC). CircRSU1, highly abundant in HCC, interacts with and stabilizes hnRNPA1 from ubiquitination and degradation. This stabilization facilitates hnRNPA1 binding to the internal ribosome entry site of HIF1A to increase HIF‐1α protein translation.
Shuting Xue, Danduo Wei, Yongzhi Zhao, Jinchang Pan, Hanyuan Zhang, Niya Liu, Jianjuan Zhang, Jiaxin Liu, Jianping Jin, Mu Xiao, Xinhua Feng, Aifu Lin, Lei Zhao, Stephanie Roessler, Junfang Ji   +14 more
wiley   +1 more source

[The biological specimen bank: methodological and organizational problems].

Annali dell'Istituto superiore di sanita, 1993
Little experience is available to solve methodological and organizational problems when setting up a biological specimen bank as a support to prospective studies on chronic diseases. Sample aliquots preparation, processing procedures and storage system are discussed in the present paper. Problems related to the quality of biological material stored, as
openaire   +1 more source

Evolutionary associations between sand seatrout (Cynoscion arenarius) and silver seatrout (C. nothus) inferred from morphological characters, mitochondrial DNA, and microsatellite markers [PDF]

, 2009
The evolutionary associations between closely related fish species, both contemporary and historical, are frequently assessed by using molecular markers, such as microsatellites.
Anderson, Joel D., Karel, William J., McDonald, Dusty L., Sutton, Glen R.   +3 more
core  

Recommendations for collaborative paediatric research including biobanking in Europe: a Single Hub and Access point for paediatric Rheumatology in Europe (SHARE) initiative [PDF]

, 2017
Innovative research in childhood rheumatic diseases mandates international collaborations. However, researchers struggle with significant regulatory heterogeneity; an enabling European Union (EU)-wide framework is missing.
Anton, Jordi, Avcin, Tadej, Benseler, Susanne M, Beresford, Michael W, Constantin, Tamas, Eikelberg, Andreas, Foster, Helen E, Hansmann, Sandra, Haug, Iris, Hens, Kristien, Horneff, Gerd, Jaegle, Christine, Kone-Paut, Isabelle, Kuemmerle-Deschner, Jasmin B, Martini, Alberto, Ozen, Seza, Prakken, Berent J, Ravelli, Angelo, Ruperto, Nicolino, Schuller, Sabrina, Shaw, David, Sikken, Marijn, Uziel, Yosef, Vastert, Sebastiaan J, Wouters, Carine, Wulffraat, Nico M   +25 more
core   +1 more source

GPX4 Inhibitor Resistance and Metastatic Features in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study establishes breast cancer cell lines that are resistant to glutathione peroxidase 4 inhibitors (GPX4i) in vitro and investigates the metastatic capacity of the GPX4i‐resistant versus parental lines in vivo. GPX4i‐resistant cells survive upon intravenous injection, but lose capacity to spontaneously metastasize.
Marie Sabatier, Mayher Kaur, Milena Chaufan, Felix‐Levin Hormann, Luiza Martins Nascentes Melo, Mario Palma, Jordan Torpey, Yanshan Liang, Alanis Carmona, Cameron Fraser, Midori Flores, Krystina J. Szylo, Mahsa Yavari, Sheng Hui, Alpaslan Tasdogan, Sven Heiles, Jessalyn M. Ubellacker   +16 more
wiley   +1 more source

Infectious rhythms [PDF]

, 2001
A commentary on the 1st Auckland Triennial, the chapter engages with the work of artists John Lyall, Mariele Neudecker, Michael Parekowhai and Bill Hammond in order to explore the biological and cultural dimensions of inhabiting an island.
Clark, Nigel
core  

Deciphering the Impact of RAC1‐SPTAN1 in ARPKD Cystogenesis Using Multifaceted Models

Advanced Science, EarlyView.
Distal/connecting tubules expressing SLC8A1 have been suggested as a potential origin of ARPKD cysts. SPTAN1 has been identified as a key molecule in ARPKD cyst formation. Restoring SPTAN1 in PKHD1−/− organoids reduced cyst formation, normalized calcium levels, and decreased RAC1/c‐FOS expression, highlighting SPTAN1's role in ARPKD and the potential ...
Shohei Kuraoka, Yuhei Higashi, Suguru Saito, Solmaz Pourgonabadi, Honami Honjoh, Sho Ishigaki, Peter C. Harris, Lisa M. Satlin, Michifumi Yamashita, Ryuji Morizane   +9 more
wiley   +1 more source

Ethical and legal considerations regarding the ownership and commercial use of human biological materials and their derivatives

Journal of Blood Medicine, 2012
Carlo PetriniItalian National Institute of Health, Rome, ItalyAbstract: This article considers some of the ethical and legal issues relating to the ownership and use – including for commercial purposes – of biological material and ...
Petrini C
doaj  

The Deer Flies of Indiana (Diptera: Tabanidae: \u3ci\u3eChrysops\u3c/i\u3e) [PDF]

, 2017
(excerpt) The great majority of specimens, over 12,000 out of 13,185, which form the basis of this study, were collected by the writer during the flight season of the summer of 1963.
Burton, John J.S
core   +2 more sources