Results 111 to 120 of about 29,478,974 (394)

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

open access: yesFEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro   +2 more
wiley   +1 more source

mRNA capping: biological functions and applications

open access: yesNucleic Acids Research, 2016
The 5′ m7G cap is an evolutionarily conserved modification of eukaryotic mRNA. Decades of research have established that the m7G cap serves as a unique molecular module that recruits cellular proteins and mediates cap-related biological functions such as
Anand Ramanathan, G. B. Robb, S. Chan
semanticscholar   +1 more source

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

open access: yesFEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt   +4 more
wiley   +1 more source

Empirical classification of fatigue-induced physiological tremor in robot-assisted manipulation tasks using BiLSTM-GRU network

open access: yesFrontiers in Rehabilitation Sciences
IntroductionPhysiological tremor arises due to stress, anxiety, fatigue, alcohol or caffeine. Under conventional circumstances, the physiological tremor would not be detrimental.
Poongavanam Palani   +4 more
doaj   +1 more source

Long-term coexistence for a competitive system of spatially varying gradient reaction-diffusion equations [PDF]

open access: yes, 2007
Spatial distribution of interacting chemical or biological species is usually described by a system of reaction-diffusion equations. In this work we consider a system of two reaction diffusion equations with spatially varying diffusion coefficients which
Korobeinikov, Andrei   +2 more
core  

In vivo evidence for glycyl radical insertion into a catalytically inactive variant of pyruvate formate‐lyase

open access: yesFEBS Letters, EarlyView.
Dimeric pyruvate formate‐lyase cleaves pyruvate using a radical‐based mechanism. G734 serves as a radical storage location, and the radical is transferred to the catalytic C419 residue. Mutation of the C418‐C419 pair causes loss of enzyme activity, but does not impede radical introduction onto G734. Therefore, cis‐ but not trans‐radical transfer occurs
Michelle Kammel   +2 more
wiley   +1 more source

Evolutionary interplay between viruses and R‐loops

open access: yesFEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi   +4 more
wiley   +1 more source

Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System

open access: yesInternational Journal of Molecular Sciences, 2018
The biological effects of cannabinoids, the major constituents of the ancient medicinal plant Cannabis sativa (marijuana) are mediated by two members of the G-protein coupled receptor family, cannabinoid receptors 1 (CB1R) and 2.
Shenglong Zou, U. Kumar
semanticscholar   +1 more source

Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation

open access: yesFEBS Letters, EarlyView.
The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt   +8 more
wiley   +1 more source

Basis for a neuronal version of Grover’s quantum algorithm

open access: yesFrontiers in Molecular Neuroscience, 2014
Grover’s quantum (search) algorithm exploits principles of quantum information theory and computation to surpass the strong Church-Turing limit governing classical computers.
Kevin Bradley Clark, Kevin Bradley Clark
doaj   +1 more source

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