Results 111 to 120 of about 30,599,032 (364)

Stable States of Biological Organisms

, 2009
A novel model of biological organisms is advanced, treating an organism as a self-consistent system subject to a pathogen flux. The principal novelty of the model is that it describes not some parts, but a biological organism as a whole.
A. Lichtenberg, A. Perelson, D. Sornette, D. Sornette, E. P. Yukalova, G. Nicolis, I. Prigogine, J. P. Cobb, J.-Y. Henry, N. Bogolubov, R. Thom, V. I. Yukalov, V. Yukalov, V. Yukalov   +13 more
core   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

A hybrid learning approach for MRI-based detection of alzheimer’s disease stages using dual CNNs and ensemble classifier

Scientific Reports
Alzheimer’s Disease (AD) and related dementias are significant global health issues characterized by progressive cognitive decline and memory loss. Computer-aided systems can help physicians in the early and accurate detection of AD, enabling timely ...
Sepideh Zolfaghari, Atra Joudaki, Yashar Sarbaz   +2 more
doaj   +1 more source

Engineering scalable biological systems [PDF]

Bioengineered Bugs, 2010
Synthetic biology is focused on engineering biological organisms to study natural systems and to provide new solutions for pressing medical, industrial and environmental problems. At the core of engineered organisms are synthetic biological circuits that execute the tasks of sensing inputs, processing logic and performing output functions.
openaire   +4 more sources

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Multispectral, Thermal, and Hyperspectral Sensing Data Depict Stomatal Conductance in Grapevine

Remote Sensing
Climate-driven water challenges in the Pacific Northwest necessitate precise irrigation for sustainable vineyard management. In such scenarios, conservation of water using different approaches, including subsurface irrigation, becomes critical. Detecting
Kesevan Veloo, Carlos Zúñiga Espinoza, Alberto Espinoza Salgado, Pete W. Jacoby, Sindhuja Sankaran   +4 more
doaj   +1 more source

Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System

International Journal of Molecular Sciences, 2018
The biological effects of cannabinoids, the major constituents of the ancient medicinal plant Cannabis sativa (marijuana) are mediated by two members of the G-protein coupled receptor family, cannabinoid receptors 1 (CB1R) and 2.
Shenglong Zou, U. Kumar
semanticscholar   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Computational Modeling of Three-Dimensional Electrodiffusion in Biological Systems: Application to the Node of Ranvier [PDF]

, 2008
Courtney L. Lopreore, Thomas M. Bartol, Jay S. Coggan, Daniel Keller, Gina E. Sosinsky, Mark H. Ellisman, Terrence J. Sejnowski   +6 more
openalex   +1 more source

Homeostatic Mechanisms of Biological Systems: Prolegomena

, 2023
В. М. Захаров, Ilya Trofimov
openalex   +1 more source