Results 191 to 200 of about 5,744,468 (268)

Studying When to Add Biological Therapy to Cytotoxic Therapy in Advanced Cancer Care Using Real World Data: How to Avoid Design Choices That Generate Immortal Time. [PDF]

Cancer Med
Garcia-Albeniz X, Vila-Guilera J, Zamparini M, Oliveres H, Alonso-Orduna V, Feliu J, Fernández-Montes A, Martín-Richard M, Gálvez-Munoz E, Ruiz-Casado A, Yubero-Esteban A, Aparicio J, Alcaide-Garcia J, Plazas JG, Fernandez-Martos C, Gallego-Sanchez R, Morales MG, Leno R, Esposito F, Lopez-Prades S, Cuatrecasas M, Dickerman BA, Maurel J.   +22 more
europepmc   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Novel Small-Molecule Treatment and Emerging Biological Therapy for Psoriasis. [PDF]

Biomedicines
Li Y, Cheng Y, Cai Y, Duan Z, Xu H, Huang Y, Ma X, Xin X, Yin L.   +8 more
europepmc   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Emerging Therapies in the Treatment of Prurigo Nodularis: Biological Therapy and Systematic Review of Literature. [PDF]

Dermatol Ther (Heidelb)
Licata G, Arisi M, Giorgio CM, Ariasi C, Tomasi C, Soglia S, Mezzana S, Galli B, Artelli GL, Rossi M, Catapano C.   +10 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Predicting resistance to biological therapy using human leukocyte antigen genes in patients with inflammatory bowel disease. [PDF]

Ther Adv Gastroenterol
Domingues Â, Carvalho A, Martinho A, Soares C, Martins D, Sousa P, Araújo R, Cancela E, Silva A, Ministro P.   +9 more
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Evaluation of Long-Term Response to Biological Therapy in Severe Asthma and Considerations for Treatment Adjustment. [PDF]

J Clin Med
Giordani J, Pini A, Pini L.
europepmc   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source