Results 1 to 10 of about 118,147 (316)

Biologics developability data analysis using hierarchical clustering accelerates candidate lead selection, optimization, and preformulation screening

mAbs
Identification of an optimal single protein sequence at the discovery stage for preclinical and clinical development is critical to the rapid development and overall success of a biologic drug.
Kevin James Metcalf, Galen Wo, Jan Paulo Zaragoza, Fahimeh Raoufi, Jeanne Baker, Daoyang Chen, Mehabaw Derebe, Jason Hogan, Amy Hsu, Esther Kofman, David Leigh, Mandy Li, Dan Malashock, Cate Mann, Soha Motlagh, Jihea Park, Karthik Sathiyamoorthy, Madhura Shidhore, Yinyan Tang, Kevin Teng, Katharine Williams, Andrew Waight, Sultan Yilmaz, Fan Zhang, Huimin Zhong, Laurence Fayadat-Dilman, Marc Bailly   +26 more
doaj   +1 more source

1339 Systemically administered onco-selective mRNA LNP achieves tumor regression and improves overall survival, as monotherapy

Journal for ImmunoTherapy of Cancer, 2023
Manfred Kraus, Aniela Jakubowski, Yulia Rybakova, Nicole Lessard, Rudy Christmas, Tom Addison, Leona Lee, Jieni Xu, Mark Krimmer, Cafer Ozdemir, Burak Yilmaz, Yusuf Erkul, Isaak Mueller   +12 more
doaj   +1 more source

Modular generation of multispecific antibodies using protein trans-splicing

mAbs
Multispecific antibodies are exhibiting rapid growth in drug development due to their ability to engage multiple therapeutic targets and deliver unique functional properties inaccessible to conventional monoclonal antibodies.
Jared A. Shadish, John D. Bagert, Amber N. Lee, Kenneth K. Sharp, Chunning Yang, Yijia Li, Rui Wang, Seungwook Shin, Alina A. Malik, Jia Lin, Fengying Huang, Wenhai Liu, Yariv Mazor   +12 more
doaj   +1 more source

DB-1314, a novel DLL3-targeting ADC with DNA topoisomerase I inhibitor, exhibits promising safety profile and therapeutic efficacy in preclinical small cell lung cancer models

Journal of Translational Medicine
Background Delta-like ligand 3 (DLL3) is highly expressed on the cell surface of small cell lung cancer (SCLC), one of the most lethal malignancies, but minimally or not in normal tissues, making it an attractive target for SCLC.
Shengchao Lin, Yu Zhang, Jun Yao, Junjie Yang, Yang Qiu, Zhongyuan Zhu, Haiqing Hua   +6 more
doaj   +1 more source

350 Enhancing directly selected tumor-reactive TIL function through genetic modification

Journal for ImmunoTherapy of Cancer, 2023
Christophe Pedros, Emily Carron, Larissa Pikor, Barbara Sennino, Sowbarnika Ratliff, April Fraley, Justin Rahman, Niloufar Khojandi, Bryant Thompson, Mathew Thayer   +9 more
doaj   +1 more source

DB-1310, an ADC comprised of a novel anti-HER3 antibody conjugated to a DNA topoisomerase I inhibitor, is highly effective for the treatment of HER3-positive solid tumors

Journal of Translational Medicine
Background HER3 (ErbB3), a member of the human epidermal growth factor receptor family, is frequently overexpressed in various cancers. Multiple HER3-targeting antibodies and antibody–drug conjugates (ADCs) were developed for the solid tumor treatment ...
Xi Li, Jun Yao, Chen Qu, Lan Luo, Bing Li, Yu Zhang, Zhongyuan Zhu, Yang Qiu, Haiqing Hua   +8 more
doaj   +1 more source

719 Phase 1 clinical trial design of ZM008, a first-in-class anti LLT1 antibody is a promising therapy for multiple solid cancers

Journal for ImmunoTherapy of Cancer, 2023
Ignacio Garcia-Ribas, Maloy Ghosh, Anurag Tiwari, Sanghamitra Bhattacharjee, Yogendra Manjunath, Shalini Kashipathi, Subith Krishna, Ashvini Kumar Dubey, Tirtha Mandal, Soorya Gnanasegaran   +9 more
doaj   +1 more source

Navigating renal safety in the biologic treatment of psoriasis: from immunologic mechanisms to clinical practice. [PDF]

Front Immunol
Tang Z, Wu J, Dong M, Li C, Wang R.
europepmc   +1 more source

Mortality Among Adults with Subspecialist-Treated Severe Asthma: A Descriptive Analysis from the Observational CHRONICLE Study. [PDF]

J Asthma Allergy
Lugogo NL, Trevor J, Spahn JD, Panettieri RA, Carstens DD, Ambrose CS.   +5 more
europepmc   +1 more source

The Impact of Obesity on Airway Inflammation, Lung Function and Biologic Treatment in Asthma: A Narrative Review. [PDF]

J Inflamm Res
Hadžić B, Vasbinder EC, Lek RM, Castro Cabezas M, Braunstahl GJ.   +4 more
europepmc   +1 more source