Results 41 to 50 of about 135,075 (307)

Engineering solventogenic clostridia for commercial production of bio-chemicals

Engineering Biology, 2019
The manufacture of bio-chemicals through the use of microbial fermentation and renewable feedstock has a number of well-known advantages linked to sustainability and reduced impacts on the environment.
Nathan W. G. Fairhurst, Rachel A. Harper, Holly K. Smith, Lee C. Speight, Joseph S. Clements II, Elizabeth R. Jenkinson   +5 more
doaj   +1 more source

An introduction to biologics [PDF]

, 2012
An introduction to biologics\ud 23.1 Introduction: Principles of biologics and their use as medicines\ud 23.2 Protein biologics used as drugs\ud 23.2.1 Proteins that function through enzymatic or regulatory activity.\ud 23.2.1.1 Biologics as replacement ...
Mullaney, Ian
core  

Chemotherapy for Spinal Cord Intramedullary Pediatric Low‐Grade Glioma—A Systematic Literature Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric intramedullary low‐grade gliomas (PIMLGGs) are rare neoplasms that present unique clinical and management challenges. Although surgery remains the primary tool for tissue diagnosis and decompression, complete gross‐total resection is frequently unfeasible due to the infiltrative nature of these lesions.
Olga M. Sergeenko, Segev Gabay, Jonathan Roth, Amit Ringel, Rina Dvir, Shlomi Constantini   +5 more
wiley   +1 more source

Extensive physicochemical and biological characterization of BP02, a trastuzumab biosimilar, and comparative assessment with Herceptin

Scientific Reports
Trastuzumab is an IgG1 monoclonal antibody that targets the extracellular HER2 domain on HER2 + cancer cells. CuraTeQ biologics has developed a trastuzumab biosimilar, code named BP02, aimed at treating early and metastatic breast cancer and metastatic ...
Sanjeeva Metikala, Maheswara Rao Bogadi, Venu Kumar Vemula, D. R. Yashwanth Kumar, Yash Patel, Babul Reddy, Naga Satish, Nagarjuna Reddy Vuchuru, Kambagiri Swamy Kayala, Pujitha Yarlagadda, Raghu K. Chitta, Srilalitha Kuruganti, Disha Dadke   +12 more
doaj   +1 more source

Bone and Soft Tissue Neoplasms in Infants Versus Older Children: A Report From the Cancer in Young People in Canada Program

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Aims Infant bone and soft tissue neoplasms present distinct clinical challenges and lack large‐scale data to inform treatment decisions. This study aims to characterize bone and soft tissue neoplasms in infants in Canada and to compare their outcomes with those of older pediatric patients.
Samuel Sassine, Hallie Coltin, Maria Kondyli, Monia Marzouki, Nicolas Prud'homme, Nida Usmani, Rebecca J. Deyell, Lesleigh Abbott, Tony H. Truong, Sapna Oberoi, Ketan Kulkarni, Josée Brossard, Lynette Bowes, Paul Gibson, Sarah McKillop, Roona Sinha, Lillian Sung, Catherine Vezina, Laura Wheaton, Alexandra P. Zorzi, Marie‐Claude Pelland‐Marcotte, Thai Hoa Tran   +21 more
wiley   +1 more source

Author Correction: Identification, characterization and control of a sequence variant in monoclonal antibody drug product: a case study

Scientific Reports, 2021
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Anushikha Thakur, Rekha Nagpal, Avik Kumar Ghosh, Deepak Gadamshetty, Sirisha Nagapattinam, Malini Subbarao, Shreshtha Rakshit, Sneha Padiyar, Suma Sreenivas, Nagaraja Govindappa, Harish V. Pai, Ramakrishnan Melarkode Subbaraman   +11 more
doaj   +1 more source

Neurocognitive, School‐Based, and Quality of Life Outcomes for Youth With Sickle Cell Disease and Thalassemia: A Scoping Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT The medical burdens of sickle cell disease (SCD) and transfusion‐dependent β‐thalassemia (TDT) are chronic and cumulative, even in children. Yet the effects expand beyond medications and healthcare visits due to their impacts on school attendance, academic performance, and peer engagement.
Mary Ann Etling, Hakim Tokhi, Alexander A. Boucher   +2 more
wiley   +1 more source

Targeting LLT1 as a potential immunotherapy option for cancer patients non-responsive to existing checkpoint therapies in multiple solid tumors

BMC Cancer
Background High levels of LLT1 expression have been found in several cancers, where it interacts with CD161 on NK cells to facilitate tumor immune escape.
Tirtha Mandal, Soorya Gnanasegaran, Golding Rodrigues, Shalini Kashipathi, Anurag Tiwari, Ashvini Kumar Dubey, Sanghamitra Bhattacharjee, Yogendra Manjunath, Subith Krishna, M. S. Madhusudhan, Maloy Ghosh   +10 more
doaj   +1 more source

Comparison of SYBR Green real time PCR assay and conventional PCR for identity some commercial live poultry veterinary vaccines [PDF]

Benha Veterinary Medical Journal, 2018
Escherichia coli (E.coli) continue to be one of the major causes of food poisoning in the world. Different methods have been developed in order to reduce the time for the evaluation of the E.coli vaccines.
Reem Soliman, Hala Mahmoud, Mohamed AbdelKhalek, Mounir M Elsafty, Marwa Fathy, Ahmed Maher   +5 more
doaj   +1 more source

Representation of Sickle Cell Disease Patients in Pediatric and Adult Care: What We Discovered Using Informatics for Integrating Biology and the Bedside (i2b2) Data

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Transitioning from pediatric to adult care is a high‐risk period for individuals with sickle cell disease (SCD). An initial observation at one academic medical center suggested a sex‐based disparity in clinic populations, prompting a national investigation.
Laurie J. Duckworth, Kholod Alhassan, Ada De La Osa, John Stephen, Yue Yao, Diana J. Wilkie   +5 more
wiley   +1 more source