Results 61 to 70 of about 118,147 (316)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Clinical use of biologics in vasculitis syndromes

, 2012
Marino ParoliDivision of Clinical Immunology and Rheumatology, Department of Biotechnology and Medical-Surgical Sciences, Sapienza University of Rome, ItalyAbstract: Vasculitis syndromes are relative rare conditions but can cause significant mortality ...
PAROLI, Marino, Paroli M
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Teaching biologics formulation using molecular modeling and simulations

, 2023
Teaching chemistry and chemical engineering students about biologics formulation remains challenging despite its increasing importance in pharmaceutical development. Monoclonal antibodies, commonly called mAbs, are the most popular biologics.
Savannah, Bruno, Pin-Kuang, Lai, Sarah , Hurley, Vy , Nguyen, Andrew, Phillips, Anusha, Srinivas, Matthew, Kustrup, Margaret, O\u27Dea, Ilina Prentoska, Prentoska   +8 more
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Harnessing innate lung anti-cancer effector functions with a novel bacterial-derived immunotherapy

OncoImmunology, 2018
Acute infection is known to induce strong anti-tumor immune responses, but clinical translation has been hindered by the lack of an effective strategy to safely and consistently provoke a therapeutic response.
Mark Bazett, Amanda M. Costa, Momir Bosiljcic, Rebecca M. Anderson, Matthew P. Alexander, Stephanie W. Y. Wong, Salim Dhanji, Jenny MH Chen, Jim Pankovich, Stephen Lam, Simon Sutcliffe, Hal Gunn, Shirin Kalyan, David W. Mullins   +13 more
doaj   +1 more source

Preparation of monospecific antisera against fowl cholera, fowl coryza and Newcastle disease reference strains in laboratory animals [PDF]

Veterinary Medical Journal - Giza, 2011
 Monospecific antisera against Paneurella multocida strains that belonged to capralar and somatic serogroups A:1, A:3 and A:4, Avibacterium paragallinarum serovars A and C and Newcastle disease virus, were prepared in three separate rabbit groups for ...
Hanan Mahmoud, Abdel Baky H, Ghada El-Sadek, Amal El-Sawah, Hanaa Mostafa, El-Safty M, Elham El-Ebiary   +6 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Pharmacokinetic/LDL‐C and exposure–response analysis of tafolecimab in Chinese hypercholesterolemia patients: Results from phase I, II, and III studies

Clinical and Translational Science, 2023
Tafolecimab, a novel fully human monoclonal antibody targeting PCSK9, has been assessed in Chinese healthy volunteers and patients with hypercholesterolemia.
Shuling Yan, Xia Zhao, Qiushi Xie, Weijuan Du, Qingyang Ma, Tongkang Zhu, Huan Deng, Lei Qian, Shirui Zheng, Yimin Cui   +9 more
doaj   +1 more source