Results 61 to 70 of about 169,450 (313)

A four-stage process that identified a hydroxypropyl beta cyclodextrin and polysorbate containing formulation that eliminated aggregation of recombinant human NELL-1 after exposure to extrinsic stresses

AAPS Open
Background Recombinant human NELL-1 (rhNELL-1) is a potent osteogenic protein with therapeutic potential in regenerative medicine. A stable formulation is essential to prevent aggregation during production, filling, storage, and clinical use. Methodology
Lun Xin, Zhe Zhang, Monika Prorok, Leon Li, Ruoshui Ma, Yunsong Li, Brent Lee Atkinson   +6 more
doaj   +1 more source

Predicting Antibody Developability Profiles Through Early Stage Discovery Screening

mAbs, 2020
Monoclonal antibodies play an increasingly important role for the development of new drugs across multiple therapy areas. The term ‘developability’ encompasses the feasibility of molecules to successfully progress from discovery to development via ...
Marc Bailly, Carl Mieczkowski, Veronica Juan, Essam Metwally, Daniela Tomazela, Jeanne Baker, Makiko Uchida, Ester Kofman, Fahimeh Raoufi, Soha Motlagh, Yao Yu, Jihea Park, Smita Raghava, John Welsh, Michael Rauscher, Gopalan Raghunathan, Mark Hsieh, Yi-Ling Chen, Hang Thu Nguyen, Nhung Nguyen, Dan Cipriano, Laurence Fayadat-Dilman   +21 more
doaj   +1 more source

Adverse reactions of biological therapies in patients with psoriasis [PDF]

, 2017
Psoriasis is a chronic, immune-mediated disorder characterized by well demarcated, erythematous plaques covered by thick, silvery-white scales, most often located on the knees, elbows, sacral area and scalp.
Georgescu, Simona R., Limbău, Alexandra M., Mitran, Cristina I., Mitran, Mădălina I., Sârbu, Maria I., Tampa, Mircea   +5 more
core   +4 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Discovery and multimerization of cross-reactive single-domain antibodies against SARS-like viruses to enhance potency and address emerging SARS-CoV-2 variants

Scientific Reports, 2023
Coronaviruses have been the causative agent of three epidemics and pandemics in the past two decades, including the ongoing COVID-19 pandemic. A broadly-neutralizing coronavirus therapeutic is desirable not only to prevent and treat COVID-19, but also to
Scott A. Hollingsworth, Cameron L. Noland, Karin Vroom, Anasuya Saha, Miranda Sam, Qinshan Gao, Haihong Zhou, David U. Grandy, Sujata Singh, Zhiyun Wen, Christopher Warren, Xiaohong Shirley Ma, Daniel Malashock, Jennifer Galli, Gwenny Go, Michael Eddins, Todd Mayhood, Karthik Sathiyamoorthy, Arthur Fridman, Fahimeh Raoufi, Yacob Gomez-Llorente, Andrea Patridge, Yinyan Tang, Shi-Juan Chen, Marc Bailly, Chengjie Ji, Laura J. Kingsley, Alan C. Cheng, Bernhard H. Geierstanger, Daniel M. Gorman, Lan Zhang, Kalyan Pande   +31 more
doaj   +1 more source

Guidance on noncorticosteroid systemic immunomodulatory therapy in noninfectious uveitis: fundamentals of care for uveitis (focus) initiative [PDF]

, 2018
Topic: An international, expert-led consensus initiative to develop systematic, evidence-based recommendations for the treatment of noninfectious uveitis in the era of biologics.
Acharya, Nisha, Adan, Alfredo, Agrawal, Rupesh, Akkoc, Nurullah, Al Ghamdi, Saed, Al Ghamdi, Turki, Al Saati, Anood, Al-Dhibi, Hassan A., Al-Shamarani, Mohamed, Alsabaani, Nasser, Bachta, Artur, Barisani-Asenbauer, Talin, Beare, Nicholas, Belga Ottoni Porto, Fernanda, Blanco, Ricardo, Brézin, Antoine P., Carreño, Ester, Chan Sook Yee, Anita, Chandran, Vinod, Chiquet, Christophe, Cimbalas, Andrius, Cimino, Luca, Cordero-Coma, Miguel, Correspondence information about the author FMedSci, FRCOphth, Cristobal, Couto, Cuevas, Miguel, Davis, Janet L., de Boer, Joke, de la Torre, Alejandra, De Schryver, Ilse, Derzko-Dzulynsky, Larissa, Diaz-Valle, David, Dick, Andrew D., Dick, FRCOphth Andrew D., Dick†, FRCOphth Andrew D., Eugenia Duran Merino, Claudia, Eurico da Fonseca, João, Facsko, Andrea, Figueira, Luis, FMedSci,, Fonollosa, Alejandro, Fortin, Eric, FRCOphth,, FRCPCH, FRCP, FRCS, FRCOphth, FRCSEd(Ophth), FRCOphth, Gale, Richard, Galeazzi, Mauro, Garcia, Sandra, Gašperšič, Nataša, Goldstein, Debra, Guedes, Marta, Guex-Crosier, Yan, Gul, Ahmet, Hamam, Rola, Haroon, Muhammad, Hasegawa, Kenichi, Hee Chng, Hiok, Heiligenhaus, Arnd, Hisae Yamamoto, Joyce, Hooper, Claire, Hwang, De-Kuang, Hwang, Yih-Shiou, Jr., Rubens Belfort, Juanola, Xavier, Kaburaki, Toshikatsu, Kadayifcilar, Sibel, Kempen, John, Kezuka, Takeshi, Kherani, Amin, Kiak Lim, Wee, Kirsimäe, Maarja, Kotaniemi, Kaisu, Kraut, Aleksandra, Kubicka-Trząska, Agnieszka, Kuffova, Lucia, Lightman, Susan, Lim, Lyndell, MA, MD, Maria Garcia Ruiz de Morales, Jose, Massimo Accorinti, MBChB(Hons), McCluskey, Peter, McGuire, Mairide, MD,, MD,, MD,, MD,, MD†,, Mirabelli, Pierfrancesco, Miserocchi, Elisabetta, Misiuk-Hojło, Marta, Muccioli, Cristina, Murphy, Conor, Murray, Philip I., Muñoz, Santiago, Nagy, Zoltan, Namba, Kenichi, Nascimento, Heloisa, Neri, Piergiorgio, Nguyen, Quan, O'Gradaigh, Donncha, Omair, Mohammed, Otsa, Kati, Ozyazgan, Yilmaz, Pablo, Franco, PAROLI, Maria Pia, Phaik Chee, Soon, PhD, MD, PhD, MD, PhD, MD, PhD, MD, Pleyer, Uwe, Poór, Gyula, Proença, Rui, Rabinovitch, Theodore, Ramanan, Athimalaipet V., Read, Russell, Rebrov, Margarita, Recillas-Gispert, Claudia, Rosenbaum, James T., Rothova, Aniki, Salah, Sawsen, Salek, Sherveen, Schwartzman, Sergio, Seve, Pascal, Sharma, Srilakshmi, Siak, Jay, Sims, Joanne, Sohár, Nicolette, Sonoda, Koh-Hei, Steeples, Laura, Suhler, Eric, Szepessy, Zsuzsanna, Szántó, Sándor, Tappeiner, Christoph, the author FMedSci, Email, Thorne, Jennifer, Tugal Tutkun, Ilknur, Turno-Kręcicka, Anna, Van Calster, Joachim, van der Horst-Bruinsma, Irene, Vidovič Valentinčič, Nataša, Vitale, Albert, Voorduin Ramos, Stephanie, Vukojevic, Nenad, Wakefield, Denis, Willermain, François, Yalcindag, Nilufer, Yeh, Stephen, Zemaitiene, Reda, Ziouzina, Olga   +150 more
core   +1 more source

Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion

Pediatric Blood &Cancer, EarlyView.
Marllon Cindra Sant'Ana, Mariana Maschietto, Daniela Paz Leal, Ricardo de Santos de Oliveira, Mayara Ferreira Euzébio, Antonio Carlos dos Santos, Luciano Neder, Carlos Alberto Scrideli, Elvis Terci Valera   +8 more
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Impact of the Human Genome Project at the Interface between Patent and FDA Laws [PDF]

, 1996
Mr. Cunningham stresses the broad scope of biotechnological innovations. Besides endorsing the need for a new oversight commission to deal with potential social issues, he suggests, for example, that some products should be treated like biologics rather ...
Cunningham, Brian C.
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source