Results 71 to 80 of about 135,075 (307)
Essays in Biochemistry, 2015 Biological membranes allow life as we know it to exist. They form cells and enable separation between the inside and outside of an organism, controlling by means of their selective permeability which substances enter and leave. By allowing gradients of ions to be created across them, membranes also enable living organisms to generate energy.
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ADMET and DMPKBackground and purpose: As a classic β-blocker with low systemic clearance, metoprolol has been linked to rare but clinically significant hepatotoxicity, yet its hepatic metabolic fate remains poorly characterized.
Jiang Pu +9 more
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Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
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Biological assays with special reference to biological standards [PDF]
Journal of Hygiene, 1950 A paper on biological assays and biological standards might be expected to start with a definition. What is a biological assay and what is a biological standard? However, I shall for the moment make the somewhat doubtful assumption that we all know the answer to those questions but shall return to them later, making a start meanwhile by discussing some
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Characterizing Markets for Biopharmaceutical Innovations: Do Biologics Differ from Small Molecules? [PDF]
Much has been written about the seemingly less formal, more agile biotechnology industry and its extensive interactions with academia and startups, as well as its distinct scientific, manufacturing and regulatory profile.
Mark Trusheim +2 more
core
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Harnessing innate lung anti-cancer effector functions with a novel bacterial-derived immunotherapy
OncoImmunology, 2018 Acute infection is known to induce strong anti-tumor immune responses, but clinical translation has been hindered by the lack of an effective strategy to safely and consistently provoke a therapeutic response.
Mark Bazett +13 more
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Follow-On Biologics: Intellectual Property and Innovation Issues [PDF]
, 2007 This report reviews doctrinal and policy issues pertaining to follow-on biologics. The report first introduces the application of federal food and drug legislation to follow-on biologics.
Thomas, John R., Schacht, Wendy H.
core
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
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FDA Approval of Generic Biologics: Finding a Regulatory Pathway [PDF]
, 2007 Biologics are becoming increasingly important for the potential treatment of widespread diseases such as cancer, anemia, and diabetes. As hundreds of biologics are going off-patent, the market has become ripe for the introduction of generic biologics.
Kelleher, Kathleen R.
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