Results 1 to 10 of about 1,117 (238)

Blueprint for antibody biologics developability

MAbs, 2023
Large-molecule antibody biologics have revolutionized medicine owing to their superior target specificity, pharmacokinetic and pharmacodynamic properties, safety and toxicity profiles, and amenability to versatile engineering. In this review, we focus on
Xuejin Zhang
exaly   +4 more sources

Assessing developability early in the discovery process for novel biologics

MAbs, 2023
Beyond potency, a good developability profile is a key attribute of a biological drug. Selecting and screening for such attributes early in the drug development process can save resources and avoid costly late-stage failures.
Mónica L Fernández-Quintero, Anne Ljungars, Franz Waibl   +2 more
exaly   +6 more sources

Developability considerations for bispecific and multispecific antibodies

MAbs
Bispecific antibodies (bsAb) and multispecific antibodies (msAb) encompass a diverse variety of formats that can concurrently bind multiple epitopes, unlocking mechanisms to address previously difficult-to-treat or incurable diseases. Early assessment of
Raffi Tonikian
exaly   +4 more sources

Current advances in biopharmaceutical informatics: guidelines, impact and challenges in the computational developability assessment of antibody therapeutics

MAbs, 2022
Therapeutic monoclonal antibodies and their derivatives are key components of clinical pipelines in the global biopharmaceutical industry. The availability of large datasets of antibody sequences, structures, and biophysical properties is increasingly ...
Rahul Khetan, Robin Curtis, Charlotte M Deane   +2 more
exaly   +4 more sources

PROPERMAB: an integrative framework for in silico prediction of antibody developability using machine learning

MAbs
Selection of lead therapeutic molecules is often driven predominantly by pharmacological efficacy and safety. Candidate developability, such as biophysical properties that affect the formulation of the molecule into a product, is usually evaluated only ...
Bian Li, Dingjiang Liu, Matthew C Franklin   +2 more
exaly   +4 more sources

Separating clinical antibodies from repertoire antibodies, a path to in silico developability assessment

MAbs, 2022
Approaches for antibody discovery have seen substantial improvement and success in recent years. Yet, advancing antibodies into the clinic remains difficult because therapeutic developability concerns are challenging to predict.
Christopher Negrón, W Blaine Stine
exaly   +3 more sources

An accelerated surface-mediated stress assay of antibody instability for developability studies

MAbs, 2020
High physical stability is required for the development of monoclonal antibodies (mAbs) into successful therapeutic products. Developability assays are used to predict physical stability issues such as high viscosity and poor conformational stability ...
Umberto Capasso Palmiero, Nikolai Lorenzen, Paolo Arosio   +2 more
exaly   +3 more sources

AI/ML combined with next-generation sequencing of VHH immune repertoires enables the rapid identification of de novo humanized and sequence-optimized single domain antibodies: a prospective case study

Frontiers in Molecular Biosciences, 2023
Introduction: In this study, we demonstrate the feasibility of yeast surface display (YSD) and nextgeneration sequencing (NGS) in combination with artificial intelligence and machine learning methods (AI/ML) for the identification of de novo humanized ...
Paul Arras, Paul Arras, Han Byul Yoo, Lukas Pekar, Thomas Clarke, Lukas Friedrich, Christian Schröter, Jennifer Schanz, Jason Tonillo, Vanessa Siegmund, Achim Doerner, Simon Krah, Enrico Guarnera, Stefan Zielonka, Stefan Zielonka, Andreas Evers   +15 more
doaj   +1 more source

Accelerating therapeutic protein design with computational approaches toward the clinical stage

Computational and Structural Biotechnology Journal, 2023
Therapeutic protein, represented by antibodies, is of increasing interest in human medicine. However, clinical translation of therapeutic protein is still largely hindered by different aspects of developability, including affinity and selectivity ...
Zhidong Chen, Xinpei Wang, Xu Chen, Juyang Huang, Chenglin Wang, Junqing Wang, Zhe Wang   +6 more
doaj   +1 more source

Design of developable surface via CSA-based modification of boundary curves

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2020
In this paper, we present a new method for generating high-accuracy developable surface from two design curves via crow search algorithm (CSA) based modification of design curves.
Huanxin CAO, Hongchan ZHENG, Gang HU
doaj   +1 more source