Results 11 to 20 of about 1,117 (238)
Proceedings of the American Mathematical Society, 1982 The converse of an old result of Bing turns out to be a very interesting characterization of developability. It is interesting in the sense that it provides a unifying framework for certain classical results of Bing, F. B. Jones, Heath and Wicke and Worrell, strengthening some of them in the process, without much effort.
H. H. Hung
openaire +3 more sources
Predicting Antibody Developability Profiles Through Early Stage Discovery Screening
mAbs, 2020 Monoclonal antibodies play an increasingly important role for the development of new drugs across multiple therapy areas. The term ‘developability’ encompasses the feasibility of molecules to successfully progress from discovery to development via ...
Marc Bailly +21 more
doaj +2 more sources
Communications BiologyDevelopability optimisation is an important step for successful biotherapeutic design. For monoclonal antibodies, developability is relatively well characterised. However, progress for novel biotherapeutics such as nanobodies is more limited. Differences
Gemma L. Gordon +3 more
doaj +2 more sources
Communications BiologyDesigning effective monoclonal antibody (mAb) therapeutics faces a multi-parameter optimization challenge known as “developability”, which reflects an antibody’s ability to progress through development stages based on its physicochemical properties ...
Habib Bashour +14 more
doaj +2 more sources
mAbsIn silico assessment of antibody developability during early lead candidate selection and optimization is of paramount importance, offering a rapid and material-free screening approach.
Eliott Park, Saeed Izadi
doaj +2 more sources
mAbsDeveloping therapeutic antibodies is a challenging endeavor, often requiring large-scale screening to produce initial binders, that still often require optimization for developability.
Frédéric A. Dreyer +19 more
doaj +3 more sources
mAbsThe Ginkgo Datapoints Antibody Developability (AbDev) Competition, a blinded benchmark for developability prediction characterized entirely on a single, industrial-scale experimental platform, was conducted from September 8 to November 18, 2025.
Lood van Niekerk +34 more
doaj +3 more sources
Developability-preserved Free-form Deformation of Assembled Patches
, 2004 A novel and practical approach is presented in this paper that solves a constrained free-form deformation (FFD) problem where the developability of the tessellated embedded surface patches is preserved during the lattice deformation.
Wang, C. C. L., Tang, K.
core +4 more sources
Machine learning prediction of methionine and tryptophan photooxidation susceptibility
Molecular Therapy: Methods & Clinical Development, 2021 Photooxidation of methionine (Met) and tryptophan (Trp) residues is common and includes major degradation pathways that often pose a serious threat to the success of therapeutic proteins.
Jared A. Delmar +6 more
doaj +1 more source
The Development of "Development" [PDF]
Indonesia, 1988 Approaching the end of the twentieth century, the majority of us who have had some schooling are accustomed to see the sun rise over the eastern horizon every morning. And we believe our perceptions, even though the sun has never risen over any horizon whatsoever.
Ariel Heryanto, Nancy Lutz
openaire +1 more source