MAbsSelection of lead therapeutic molecules is often driven predominantly by pharmacological efficacy and safety. Candidate developability, such as biophysical properties that affect the formulation of the molecule into a product, is usually evaluated only ...
Matthew Franklin, Mohammed Shameem
exaly +4 more sources
Proceedings of the American Mathematical Society, 1982 The converse of an old result of Bing turns out to be a very interesting characterization of developability. It is interesting in the sense that it provides a unifying framework for certain classical results of Bing, F. B. Jones, Heath and Wicke and Worrell, strengthening some of them in the process, without much effort.
H. H. Hung
openaire +3 more sources
Predicting Antibody Developability Profiles Through Early Stage Discovery Screening
mAbs, 2020 Monoclonal antibodies play an increasingly important role for the development of new drugs across multiple therapy areas. The term ‘developability’ encompasses the feasibility of molecules to successfully progress from discovery to development via ...
Marc Bailly +21 more
doaj +2 more sources
Developability-preserved free-form deformation of assembled patches
, 2004 A novel and practical approach is presented in this paper that solves a constrained free-form deformation (FFD) problem where the developability of the tessellated embedded surface patches is preserved during the lattice deformation.
Wang, Charlie C.L.; id_orcid, Tang, Kai
core +13 more sources
Context matters in PROTAC design: navigating the trade-off between degradation and developability [PDF]
Journal of Enzyme Inhibition and Medicinal ChemistryProteolysis-targeting chimaeras (PROTACs) couple target recognition to ubiquitin-dependent degradation, but their translation requires coordinated optimisation of degradation efficiency and developability.
Boxin Zhang +11 more
doaj +2 more sources
Impact of process impurities on developability assessments of complex antibody formats: the striking role of leachable copper [PDF]
mAbsThe assessment of developability and physical stability of antibody therapeutics is a cornerstone of modern biopharmaceutical discovery, increasingly relying on high-throughput automation to screen candidates to identify the most suitable lead candidate.
Vincent Wieser +6 more
doaj +2 more sources
2025 Ginkgo Datapoints Antibody Developability Competition outcomes: limited model performance and a call for data standardization [PDF]
mAbsThe Ginkgo Datapoints Antibody Developability (AbDev) Competition, a blinded benchmark for developability prediction characterized entirely on a single, industrial-scale experimental platform, was conducted from September 8 to November 18, 2025.
Lood van Niekerk +34 more
doaj +2 more sources
Self-interaction nanoparticle spectroscopy predicts high-concentration viscosity of therapeutic IgG1 antibodies [PDF]
mAbsPredicting high-concentration viscosity of monoclonal antibodies is crucial for their development as therapeutics for subcutaneous delivery, but traditional experimental rheometry methods for assessing viscosity are low-throughput, which limits their ...
Santosh Kumar Paidi +17 more
doaj +2 more sources
Biophysical cartography of the native and human-engineered antibody landscapes quantifies the plasticity of antibody developability [PDF]
Communications BiologyDesigning effective monoclonal antibody (mAb) therapeutics faces a multi-parameter optimization challenge known as “developability”, which reflects an antibody’s ability to progress through development stages based on its physicochemical properties ...
Habib Bashour +14 more
doaj +2 more sources
Model-Based Risk Assessment of mAb Developability
, 2022 \ua9 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG. Monoclonal antibodies were already one of the fastest growing sectors of biopharmaceutical industry [1].
Kizhedath A, Karlberg M, Glassey J
core +4 more sources