Computational design of therapeutic antibodies with improved developability: efficient traversal of binder landscapes and rescue of escape mutations [PDF]
mAbsDeveloping therapeutic antibodies is a challenging endeavor, often requiring large-scale screening to produce initial binders, that still often require optimization for developability.
Frédéric A. Dreyer +19 more
doaj +2 more sources
2025 Ginkgo Datapoints Antibody Developability Competition outcomes: limited model performance and a call for data standardization [PDF]
mAbsThe Ginkgo Datapoints Antibody Developability (AbDev) Competition, a blinded benchmark for developability prediction characterized entirely on a single, industrial-scale experimental platform, was conducted from September 8 to November 18, 2025.
Lood van Niekerk +34 more
doaj +2 more sources
Biologics developability data analysis using hierarchical clustering accelerates candidate lead selection, optimization, and preformulation screening [PDF]
mAbsIdentification of an optimal single protein sequence at the discovery stage for preclinical and clinical development is critical to the rapid development and overall success of a biologic drug.
Kevin James Metcalf +26 more
doaj +2 more sources
Biophysical Analysis of Therapeutic Antibodies in the Early Development Pipeline [PDF]
Biologics: Targets & TherapyLeon F Willis,1 Nikil Kapur,2 Sheena E Radford,1 David J Brockwell1 1School of Molecular and Cellular Biology, Astbury Centre for Structural Molecular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, UK; 2School of Mechanical
Willis LF +3 more
doaj +2 more sources
Developing drug-like single-domain antibodies (VHH) from in vitro libraries [PDF]
mAbsHere, we describe a new VHH library for therapeutic discovery which optimizes humanness, stability, affinity, diversity, developability, and facile purification using protein A in the absence of an Fc domain.
M. Frank Erasmus +14 more
doaj +2 more sources
Accelerating therapeutic protein design with computational approaches toward the clinical stage
Computational and Structural Biotechnology Journal, 2023 Therapeutic protein, represented by antibodies, is of increasing interest in human medicine. However, clinical translation of therapeutic protein is still largely hindered by different aspects of developability, including affinity and selectivity ...
Zhidong Chen +6 more
doaj +1 more source
Frontiers in Molecular Biosciences, 2023 Introduction: In this study, we demonstrate the feasibility of yeast surface display (YSD) and nextgeneration sequencing (NGS) in combination with artificial intelligence and machine learning methods (AI/ML) for the identification of de novo humanized ...
Paul Arras +15 more
doaj +1 more source
mAbs, 2022 Approaches for antibody discovery have seen substantial improvement and success in recent years. Yet, advancing antibodies into the clinic remains difficult because therapeutic developability concerns are challenging to predict.
Christopher Negron +4 more
doaj +1 more source
Design of developable surface via CSA-based modification of boundary curves
Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2020 In this paper, we present a new method for generating high-accuracy developable surface from two design curves via crow search algorithm (CSA) based modification of design curves.
Huanxin CAO, Hongchan ZHENG, Gang HU
doaj +1 more source
Endocrine Reviews, 2018 Production of sperm and androgens is the main function of the testis. This depends on normal development of both testicular somatic cells and germ cells. A genetic program initiated from the Y chromosome gene sex-determining region Y (SRY) directs somatic cell specification to Sertoli cells that orchestrate further development.
Juho-Antti Mäkelä +3 more
openaire +2 more sources