Results 1 to 10 of about 7,275 (166)
MAbs, 2020 Manufacturability of immunoglobulin G4 (IgG4) antibodies from the Chemistry, Manufacture, and Controls (CMC) perspective has received little attention during early drug discovery.
Yueming Qian +2 more
exaly +3 more sources
Journal of Manufacturing and Materials Processing, 2021 This article develops and demonstrates a set of design-focused manufacturability constraints for the fused deposition modeling/fused filament fabrication (FDM/FFF) process.
Iwona M Jasiuk +2 more
exaly +3 more sources
Engineering the poly(A) tail for therapeutic mRNA: from expression control to manufacturing robustness [PDF]
Frontiers in Bioengineering and BiotechnologyMessenger RNA (mRNA) therapeutics have advanced rapidly, yet sequence design must now satisfy not only biological potency but also scalable manufacturing, product consistency, and immune compatibility.
Yang-Yang Zhang +5 more
doaj +2 more sources
mAbs, 2023 With the growing significance of antibodies as a therapeutic class, identifying developability risks early during development is of paramount importance.
Tushar Jain +2 more
doaj +1 more source
Pharmaceutics, 2022 Many active pharmaceutical ingredients (APIs) in the pharmaceutical pipeline require bioavailability enhancing formulations due to very low aqueous solubility.
Molly S. Adam +6 more
doaj +1 more source
Directions of improvement of massive hydraulic retaining structures [PDF]
E3S Web of Conferences, 2023 The article deals with the issues of improving hydraulic retain-ing structures of the gravity (massive) type. In order to reduce the cost of building gravity (massive) dams and increase their efficiency, a constant search for new, more efficient design ...
Balzannikov Mikhail
doaj +1 more source
Manufacturability-Based Design Optimization for Directed Energy Deposition Processes
Machines, 2023 Additive Manufacturing (AM) is the process of joining materials by selectively depositing them layer upon layer for the purpose of manufacturing parts or assemblies which are based on a 3D digital model.
Harry Bikas +2 more
doaj +1 more source
Manufacturability Analysis for Additive Manufacturing [PDF]
2019 24th IEEE International Conference on Emerging Technologies and Factory Automation (ETFA), 2019 Additive manufacturing evolved in the last years from being a rapid prototyping process to a standard manufacturing process. Nevertheless, it is still not a widely used manufacturing method due to different process-related challenges. In this context, it is of vital importance to inspect the manufacturability of the designed parts.
Manuel Mayerhofer +3 more
openaire +1 more source
Natural Killer Cell Engagers (NKCEs): a new frontier in cancer immunotherapy
Frontiers in Immunology, 2023 Natural Killer (NK) cells are a type of innate lymphoid cells that play a crucial role in immunity by killing virally infected or tumor cells and secreting cytokines and chemokines.
Minchuan Zhang +5 more
doaj +1 more source
Artificial Cells, Nanomedicine, and Biotechnology, 2023 Recent years have seen the development of a variety of mammalian library approaches for display and secretion mode. Advantages include library approaches for engineering, preservation of precious immune repertoires and their repeated interrogation, as ...
Ramona Gaa +7 more
doaj +1 more source