Results 21 to 30 of about 1,117 (238)

land developability

The data contain the land developability index at the county level in the ...
Chi, Guangqing, Hung Chak Ho
core   +3 more sources

In silico prediction of post-translational modifications in therapeutic antibodies

mAbs, 2022
Monoclonal antibodies are susceptible to chemical and enzymatic modifications during manufacturing, storage, and shipping. Deamidation, isomerization, and oxidation can compromise the potency, efficacy, and safety of therapeutic antibodies.
Shabdita Vatsa
doaj   +1 more source

Characterization and Modeling of Reversible Antibody Self-Association Provide Insights into Behavior, Prediction, and Correction

Antibodies, 2021
Reversible antibody self-association, while having major developability and therapeutic implications, is not fully understood or readily predictable and correctable.
Carl Mieczkowski, Alan Cheng, Thierry Fischmann, Mark Hsieh, Jeanne Baker, Makiko Uchida, Gopalan Raghunathan, Corey Strickland, Laurence Fayadat-Dilman   +8 more
doaj   +1 more source

Machine learning prediction of antibody aggregation and viscosity for high concentration formulation development of protein therapeutics

mAbs, 2022
Machine learning has been recently used to predict therapeutic antibody aggregation rates and viscosity at high concentrations (150 mg/ml). These works focused on commercially available antibodies, which may have been optimized for stability.
Pin-Kuang Lai, Austin Gallegos, Neil Mody, Hasige A. Sathish, Bernhardt L. Trout   +4 more
doaj   +1 more source

Approaches to expand the conventional toolbox for discovery and selection of antibodies with drug-like physicochemical properties

mAbs, 2023
Antibody drugs should exhibit not only high-binding affinity for their target antigens but also favorable physicochemical drug-like properties. Such drug-like biophysical properties are essential for the successful development of antibody drug products ...
Hristo L. Svilenov, Paolo Arosio, Tim Menzen, Peter Tessier, Pietro Sormanni   +4 more
doaj   +1 more source

High concentration formulation developability approaches and considerations

mAbs, 2023
The growing need for biologics to be administered subcutaneously and ocularly, coupled with certain indications requiring high doses, has resulted in an increase in drug substance (DS) and drug product (DP) protein concentrations.
Jonathan Zarzar, Tarik Khan, Maniraj Bhagawati, Benjamin Weiche, Jasmin Sydow-Andersen, Alavattam Sreedhara   +5 more
doaj   +1 more source

Application of a Refined Developability Classification System

, 2022
S.1090-1100In 2010, the Developability Classification System was proposed as an extension of the Biopharmaceutics Classification System to align the classification system with the need for early evaluation of drug candidates according to their ...
Butler, J., Muenster, U., Dressman, J., Rosenberger, J.   +3 more
core   +1 more source

Developability profiling of a panel of Fc engineered SARS-CoV-2 neutralizing antibodies

mAbs, 2023
To combat the COVID-19 pandemic, potential therapies have been developed and moved into clinical trials at an unprecedented pace. Some of the most promising therapies are neutralizing antibodies against SARS-CoV-2.
Andrew Dippel, Austin Gallegos, Vineela Aleti, Arnita Barnes, Xiaoru Chen, Elizabeth Christian, Jared Delmar, Qun Du, Reza Esfandiary, Erika Farmer, Andrew Garcia, Qing Li, Jia Lin, Weiyi Liu, LeeAnn Machiesky, Neil Mody, Arun Parupudi, Meagan Prophet, Keith Rickert, Kim Rosenthal, Song Ren, Harini Shandilya, Reena Varkey, Kevin Wons, Yuling Wu, Yueh-Ming Loo, Mark T. Esser, Nicole L. Kallewaard, Sarav Rajan, Melissa Damschroder, Weichen Xu, Gilad Kaplan   +31 more
doaj   +1 more source

A high-throughput platform for biophysical antibody developability assessment to enable AI/ML model training

mAbs
Antibodies must bind their targets with high affinity and specificity to achieve useful therapeutic activity. They must also possess suitable developability properties (e.g.
Ammar Arsiwala, Rebecca Bhatt, Lood van Niekerk, Porfirio Quintero-Cadena, Xiang Ao, Adam Rosenbaum, Aanal Bhatt, Alexander Smith, Yaoyu Yang, KC Anderson, Lucia Grippo, Xing Cao, Rich Cohen, Jay Patel, Joshua Moller, Olga Allen, Ali Faraj, Anisha Nandy, Jason Hocking, Ayla Ergun, Berk Tural, Sara Salvador, Joe Jacobowitz, Kristin Schaven, Mark Sherman, Sanjiv Shah, Peter M. Tessier, David W. Borhani   +27 more
doaj   +1 more source

Developing developments

Theoretical Computer Science, 1997
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +2 more sources