Results 31 to 40 of about 3,538 (271)
An accelerated surface-mediated stress assay of antibody instability for developability studies
mAbs, 2020 High physical stability is required for the development of monoclonal antibodies (mAbs) into successful therapeutic products. Developability assays are used to predict physical stability issues such as high viscosity and poor conformational stability ...
Marie R.G. Kopp +6 more
doaj +1 more source
mAbs, 2022 Machine learning has been recently used to predict therapeutic antibody aggregation rates and viscosity at high concentrations (150 mg/ml). These works focused on commercially available antibodies, which may have been optimized for stability.
Pin-Kuang Lai +4 more
doaj +1 more source
mAbs, 2023 Antibody drugs should exhibit not only high-binding affinity for their target antigens but also favorable physicochemical drug-like properties. Such drug-like biophysical properties are essential for the successful development of antibody drug products ...
Hristo L. Svilenov +4 more
doaj +1 more source
High concentration formulation developability approaches and considerations
mAbs, 2023 The growing need for biologics to be administered subcutaneously and ocularly, coupled with certain indications requiring high doses, has resulted in an increase in drug substance (DS) and drug product (DP) protein concentrations.
Jonathan Zarzar +5 more
doaj +1 more source
Theoretical Computer Science, 1997 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire +3 more sources
Developing a framework for development: A discussion [PDF]
Developmental Psychobiology, 2006 AbstractA multitude of scientific disciplines study the development of behavior. Their use of different methodological and conceptual approaches makes integration of findings difficult. In a symposium at the 38th Annual Meeting of the International Society for Developmental Psychobiology in Washington DC, the question was discussed if a general theory ...
Patrick, Bateson +3 more
openaire +2 more sources
Assessment of Therapeutic Antibody Developability by Combinations of In Vitro and In Silico Methods. [PDF]
, 2021 Although antibodies have become the fastest-growing class of therapeutics on the market, it is still challenging to develop them for therapeutic applications, which often require these molecules to withstand stresses that are not present in vivo.
core +2 more sources
ON THE DEVELOPABILITY OF LIE SUBALGEBROIDS [PDF]
, 2007 . In this paper, the Almeida-Molino obstruction to developability of transversely complete foliations is extended to Lie ...
I. Moerdijk +3 more
core +1 more source
Simultaneous affinity maturation and developability enhancement using natural liability-free CDRs
mAbs, 2022 Affinity maturation is often a necessary step for the development of potent therapeutic molecules. Many different diversification strategies have been used for antibody affinity maturation, including error-prone PCR, chain shuffling, and targeted ...
Andre A. R. Teixeira +14 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen +23 more
wiley +1 more source