Results 31 to 40 of about 16,267,247 (278)

The Development of "Development" [PDF]

Indonesia, 1988
Approaching the end of the twentieth century, the majority of us who have had some schooling are accustomed to see the sun rise over the eastern horizon every morning. And we believe our perceptions, even though the sun has never risen over any horizon whatsoever.
Ariel Heryanto, Nancy Lutz
openaire   +1 more source

A library approach for the de novo high-throughput isolation of humanized VHH domains with favorable developability properties following camelid immunization

mAbs, 2023
In this study, we generated a novel library approach for high throughput de novo identification of humanized single-domain antibodies following camelid immunization. To achieve this, VHH-derived complementarity-determining regions-3 (CDR3s) obtained from
Paul Arras, Han Byul Yoo, Lukas Pekar, C. Schröter, Thomas Clarke, S. Krah, Daniel Klewinghaus, Vanessa Siegmund, Andreas Evers, Stefan Zielonka   +9 more
semanticscholar   +1 more source

Machine learning prediction of methionine and tryptophan photooxidation susceptibility

Molecular Therapy: Methods & Clinical Development, 2021
Photooxidation of methionine (Met) and tryptophan (Trp) residues is common and includes major degradation pathways that often pose a serious threat to the success of therapeutic proteins.
Jared A. Delmar, Eugen Buehler, Ashwin K. Chetty, Agastya Das, Guillermo Miro Quesada, Jihong Wang, Xiaoyu Chen   +6 more
doaj   +1 more source

Profiling the Biophysical Developability Properties of Common IgG1 Fc Effector Silencing Variants

Antibodies, 2023
Therapeutic antibodies represent the most significant modality in biologics, with around 150 approved drugs on the market. In addition to specific target binding mediated by the variable fragments (Fvs) of the heavy and light chains, antibodies possess ...
R. Pejchal, A. Cooper, Michael E. Brown, M. Vásquez, E. Krauland   +4 more
semanticscholar   +1 more source

Developability assessment at early-stage discovery to enable development of antibody-derived therapeutics

Antibody Therapeutics, 2022
Developability refers to the likelihood that an antibody candidate will become a manufacturable, safe and efficacious drug. Although the safety and efficacy of a drug candidate will be well considered by sponsors and regulatory agencies, developability ...
Weijie Zhang, Hao Wang, Nan Feng, Yifeng Li, Jijie Gu, Zhuozhi Wang   +5 more
semanticscholar   +1 more source

Developability Approximation for Neural Implicits Through Rank Minimization [PDF]

International Conference on 3D Vision, 2023
Developability refers to the process of creating a surface without any tearing or shearing from a two-dimensional plane. It finds practical applications in the fabrication industry.
Pratheba Selvaraju
semanticscholar   +1 more source

In silico prediction of post-translational modifications in therapeutic antibodies

mAbs, 2022
Monoclonal antibodies are susceptible to chemical and enzymatic modifications during manufacturing, storage, and shipping. Deamidation, isomerization, and oxidation can compromise the potency, efficacy, and safety of therapeutic antibodies.
Shabdita Vatsa
doaj   +1 more source

Characterization and Modeling of Reversible Antibody Self-Association Provide Insights into Behavior, Prediction, and Correction

Antibodies, 2021
Reversible antibody self-association, while having major developability and therapeutic implications, is not fully understood or readily predictable and correctable.
Carl Mieczkowski, Alan Cheng, Thierry Fischmann, Mark Hsieh, Jeanne Baker, Makiko Uchida, Gopalan Raghunathan, Corey Strickland, Laurence Fayadat-Dilman   +8 more
doaj   +1 more source

Machine learning prediction of antibody aggregation and viscosity for high concentration formulation development of protein therapeutics

mAbs, 2022
Machine learning has been recently used to predict therapeutic antibody aggregation rates and viscosity at high concentrations (150 mg/ml). These works focused on commercially available antibodies, which may have been optimized for stability.
Pin-Kuang Lai, Austin Gallegos, Neil Mody, Hasige A. Sathish, Bernhardt L. Trout   +4 more
doaj   +1 more source

Approaches to expand the conventional toolbox for discovery and selection of antibodies with drug-like physicochemical properties

mAbs, 2023
Antibody drugs should exhibit not only high-binding affinity for their target antigens but also favorable physicochemical drug-like properties. Such drug-like biophysical properties are essential for the successful development of antibody drug products ...
Hristo L. Svilenov, Paolo Arosio, Tim Menzen, Peter Tessier, Pietro Sormanni   +4 more
doaj   +1 more source