Results 31 to 40 of about 4,721 (285)
Predicting Antibody Developability Profiles Through Early Stage Discovery Screening
mAbs, 2020 Monoclonal antibodies play an increasingly important role for the development of new drugs across multiple therapy areas. The term ‘developability’ encompasses the feasibility of molecules to successfully progress from discovery to development via ...
Marc Bailly +21 more
doaj +1 more source
, 2016 Is it possible, and in the first place is it even desirable, to define what "development" means and to determine the scope of the field called "developmental biology"? Though these questions appeared crucial for the founders of "developmental biology" in the 1950s, there seems to be no consensus today about the need to address them. Here, in a combined
Pradeu, Thomas +8 more
openaire +4 more sources
IgA: Structure, function and developability [PDF]
, 2019 Immunoglobulin A (IgA) plays a key role in defending mucosal surfaces against attack by infectious microorganisms. Such sites present a major site of susceptibility due to their vast surface area and their constant exposure to ingested and inhaled ...
Atkin +30 more
core +2 more sources
Approximation by mappings with singular Hessian minors
, 2017 Let $\Omega\subset\mathbb R^n$ be a Lipschitz domain.
Liu, Zhuomin +2 more
core +1 more source
Simultaneous affinity maturation and developability enhancement using natural liability-free CDRs
mAbs, 2022 Affinity maturation is often a necessary step for the development of potent therapeutic molecules. Many different diversification strategies have been used for antibody affinity maturation, including error-prone PCR, chain shuffling, and targeted ...
Andre A. R. Teixeira +14 more
doaj +1 more source
The geometric Cauchy problem for developable submanifolds
, 2019 Given a smooth distribution $\mathscr{D}$ of $m$-dimensional planes along a smooth regular curve $\gamma$ in $\mathbb{R}^{m+n}$, we consider the following problem: To find an $m$-dimensional developable submanifold of $\mathbb{R}^{m+n}$, that is, a ruled
Raffaelli, Matteo
core +1 more source
Two ways to Grid: the contribution of Open Grid Services Architecture (OGSA) mechanisms to service-centric and resource-centric lifecycles [PDF]
, 2006 Service Oriented Architectures (SOAs) support service lifecycle tasks, including Development, Deployment, Discovery and Use. We observe that there are two disparate ways to use Grid SOAs such as the Open Grid Services Architecture (OGSA) as exemplified ...
Brebner, P., Emmerich, W.
core +1 more source
Development of disulfide-stabilized Fabs for targeting of antibody-directed nanotherapeutics
mAbs, 2022 Antibody-directed nanotherapeutics (ADNs) represent a promising delivery platform for selective delivery of an encapsulated drug payload to the site of disease that improves the therapeutic index.
Melissa L. Geddie +7 more
doaj +1 more source
The chemistry and pharmacology of citrus limonoids [PDF]
, 2016 Citrus limonoids (CLs) are a group of highly oxygenated terpenoid secondary metabolites found mostly in the seeds, fruits and peel tissues of citrus fruits such as lemons, limes, oranges, pumellos, grapefruits, bergamots, and mandarins.
Ahmad +37 more
core +3 more sources
Metrization of Weakly Developable Spaces
Sultan Qaboos University Journal for Science, 2002 In this note, we present metrization of weak developability.
Abdul M. Mohamad
doaj +1 more source