Results 41 to 50 of about 4,721 (285)

Developing sustainable development [PDF]

open access: yesWIT Transactions on Ecology and the Environment, 2008
Ralf Brand and Andrew Karvonen (The ecosystem of expertise: complementary knowledges for sustainable development. Sustainability: Science, Practice and Policy, 3(1), pp 21–31, Spring 2007) suggest that sustainability poses challenges to the discourse of technical experts and that many existing models do not fit with traditional disciplinary boundaries.
B. Tomkinson   +3 more
openaire   +1 more source

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen   +23 more
wiley   +1 more source

Augmenting adaptive immunity: progress and challenges in the quantitative engineering and analysis of adaptive immune receptor repertoires

open access: yes, 2019
The adaptive immune system is a natural diagnostic and therapeutic. It recognizes threats earlier than clinical symptoms manifest and neutralizes antigen with exquisite specificity.
Abbas   +478 more
core   +1 more source

The Statistics of Crumpled Paper [PDF]

open access: yes, 2005
A statistical study of crumpled paper is allowed by a minimal 1D model: a self-avoiding line bent at sharp angles -- in which resides the elastic energy -- put in a confining potential.
A. Lobkovsky   +8 more
core   +3 more sources

An end-to-end automated platform process for high-throughput engineering of next-generation multi-specific antibody therapeutics

open access: yesmAbs, 2021
Next-generation multi-specific antibody therapeutics (MSATs) are engineered to combine several functional activities into one molecule to provide higher efficacy compared to conventional, mono-specific antibody therapeutics.
Norbert Furtmann   +16 more
doaj   +1 more source

Why and When Are Evidence‐Based Interventions Adopted in Paediatric Supportive Care? A Qualitative Exploration of the Determinants of Photobiomodulation Implementation

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Oral mucositis is a common and debilitating side effect of childhood cancer and stem cell transplant treatments. It affects the quality of life of children and young people (CYP) and places a strain on services. Photobiomodulation is recommended for oral mucositis prevention in international guidance but is poorly implemented in UK ...
Claudia Heggie   +4 more
wiley   +1 more source

How can we discover developable antibody-based biotherapeutics?

open access: yesFrontiers in Molecular Biosciences, 2023
Antibody-based biotherapeutics have emerged as a successful class of pharmaceuticals despite significant challenges and risks to their discovery and development.
Joschka Bauer   +10 more
doaj   +1 more source

Dexamethasone for Chemotherapy‐Induced Nausea and Vomiting Prevention in Pediatric Patients: International Consensus

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background An international Delphi panel of experts developed consensus statements to delineate the circumstances where the risks of dexamethasone as an antiemetic do and do not outweigh its benefits. Procedure Experts in supportive care of pediatric patients were invited to participate.
Negar Shavandi   +20 more
wiley   +1 more source

On the incompressibility of cylindrical origami patterns

open access: yes, 2016
The art and science of folding intricate three-dimensional structures out of paper has occupied artists, designers, engineers, and mathematicians for decades, culminating in the design of deployable structures and mechanical metamaterials.
Bös, Friedrich   +3 more
core   +1 more source

Identification of a novel class of autotaxin inhibitors through cross-screening [PDF]

open access: yes, 2015
Three novel series were generated in order to mimic the pharmacophoric features displayed by lead compound AM095, a Lysophosphatidic acid (LPA1) receptor antagonist. Biological evaluation of this array of putative LPA1 antagonists led us to the discovery
Budd, David C.   +8 more
core   +1 more source

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