Results 41 to 50 of about 16,267,247 (278)

De novo design of epitope-specific antibodies against soluble and multipass membrane proteins with high specificity, developability, and function

bioRxiv
We present JAM, a generative protein design system that enables fully computational design of antibodies with therapeutic-grade properties for the first time.
Surojit Biswas
semanticscholar   +1 more source

Developing developments

Theoretical Computer Science, 1997
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +2 more sources

Projection of Target Drug Particle Size in Oral Formulations Using the Refined Developability Classification System (rDCS)

Pharmaceutics, 2023
Dissolution limitations to oral absorption can occur if the time required for dissolution is longer than the transit time across the small intestine and/or if dissolution is slower than the drug’s permeation through the gut wall.
Kristian Beran, Eline Hermans, René Holm, Kia Sepassi, Jennifer Dressman   +4 more
semanticscholar   +1 more source

Guiding diffusion models for antibody sequence and structure co-design with developability properties

bioRxiv, 2023
Recent advances in deep generative methods have allowed antibody sequence and structure co-design. This study addresses the challenge of tailoring the highly variable complementarity-determining regions (CDRs) in antibodies to fulfill developability ...
Amelia Villegas-Morcillo, Jana M. Weber, M. Reinders   +2 more
semanticscholar   +1 more source

Simultaneous affinity maturation and developability enhancement using natural liability-free CDRs

mAbs, 2022
Affinity maturation is often a necessary step for the development of potent therapeutic molecules. Many different diversification strategies have been used for antibody affinity maturation, including error-prone PCR, chain shuffling, and targeted ...
Andre A. R. Teixeira, Sara D’Angelo, M. Frank Erasmus, Camila Leal-Lopes, Fortunato Ferrara, Laura P. Spector, Leslie Naranjo, Esteban Molina, Tamara Max, Ashley DeAguero, Katherine Perea, Shaun Stewart, Rebecca A. Buonpane, Horacio G. Nastri, Andrew R. M. Bradbury   +14 more
doaj   +1 more source

The Therapeutic Nanobody Profiler: characterising and predicting nanobody developability to improve therapeutic design

bioRxiv
Developability optimisation is an important step for successful biotherapeutic design. For monoclonal antibodies, developability is relatively well characterised. However, progress for novel biotherapeutics such as nanobodies is more limited. Differences
Gemma L. Gordon, João Gervásio, Colby Souders, Charlotte M. Deane   +3 more
semanticscholar   +1 more source

Molecular reshaping of phage-displayed Interleukin-2 at beta chain receptor interface to obtain potent super-agonists with improved developability profiles

Communications Biology, 2023
Interleukin-2 (IL-2) engineered versions, with biased immunological functions, have emerged from yeast display and rational design. Here we reshaped the human IL-2 interface with the IL-2 receptor beta chain through the screening of phage-displayed ...
G. Rojas, Ernesto Relova-Hernández, Annia Pérez-Riverón, Camila Castro-Martínez, Osmany Diaz-Bravo, Y. Infante, Tania Gómez, J. Solozábal, Ana Beatriz Díaz-Bravo, M. Schubert, Marlies Becker, Beatriz Pérez-Massón, Dayana Pérez-martínez, Rydell Alvarez-Arzola, Osmany Guirola, G. Chinea, L. Graça, S. Dübel, K. Leon, T. Carmenate   +19 more
semanticscholar   +1 more source

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

Metrization of Weakly Developable Spaces

Sultan Qaboos University Journal for Science, 2002
In this note, we present metrization of weak developability.
Abdul M. Mohamad
doaj   +1 more source

Development of disulfide-stabilized Fabs for targeting of antibody-directed nanotherapeutics

mAbs, 2022
Antibody-directed nanotherapeutics (ADNs) represent a promising delivery platform for selective delivery of an encapsulated drug payload to the site of disease that improves the therapeutic index.
Melissa L. Geddie, Dmitri B. Kirpotin, Neeraj Kohli, Tad Kornaga, Bjoern Boll, Maja Razlog, Daryl C. Drummond, Alexey A. Lugovskoy   +7 more
doaj   +1 more source