Results 101 to 110 of about 135,075 (307)

BIOLOGICAL EUGENICS [PDF]

Journal of Heredity, 1914
n ...
openaire   +1 more source

Leading Biologics in Pharmacy Practice: The Role of Pharmacists

Evaluate the current approaches to handling biologics, identify challenges associated with their storage and preparation, and emphasize the critical role of pharmacy education in ensuring safe and effective management of ...
Elshayeb, Amerah, Chablani, Lipika, Austin, Emily   +2 more
core   +3 more sources

AAV-mediated co-expression of an immunogenic transgene plus PD-L1 enables sustained expression through immunological evasion

Scientific Reports
Adeno-associated virus (AAV) vectors can mediate long-term expression of immunogenic transgenes in vivo through transduction of tolerogenic cells in the liver.
Travis B. McMurphy, Andrew Park, Patrick J. Heizer, Crystal Bottenfield, James H. Kurasawa, Yasuhiro Ikeda, Michael R. Doran   +6 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

ManNAc attenuates Man5 glycoform abundance through GNE-mediated metabolic channeling of UDP-GlcNAc to N-glycosylation modifications via CMP-Neu5Ac biosynthesis

mAbs
N-glycosylation, a critical quality attribute of monoclonal antibodies, plays a pivotal role in regulating pharmacokinetics and pharmacodynamics through high-mannose (Man5) glycoform modulation.
Ruiqiang Sun, Miaomiao Chai, Jiahao Man, Guiju Yang, Hai Shu, Qiancheng Wang, Cong Tian, Linlin Wang, Shanhui Liao, Yifeng Zhang, Yanyan Cao, Lisha Xia, Haili Yang, Ting Zhang, Luoyan Ma, Shenwang Cao, Qiao Gao, Yichen Le, Mingli Shi, Quanxue Li, Yinmao Fan, Hang Zhou   +21 more
doaj   +1 more source

Vaccines and biologics

, 2014
Patients with autoimmune rheumatic diseases are more susceptible to infectious complications during the course of their disease. The introduction of biologics has been a major achievement in treating these diseases, but an increased risk of infection ...
Isenberg, D, Ferreira, I
core   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Preclinical Characterization of a Novel Monoclonal Antibody NEO-201 for the Treatment of Human Carcinomas

Frontiers in Immunology, 2018
NEO-201 is a novel humanized IgG1 monoclonal antibody that was derived from an immunogenic preparation of tumor-associated antigens from pooled allogeneic colon tumor tissue extracts.
Massimo Fantini, Justin M. David, Olga Saric, Alexander Dubeykovskiy, Yongzhi Cui, Sharon A. Mavroukakis, Andrew Bristol, Christina M. Annunziata, Kwong Y. Tsang, Philip M. Arlen   +9 more
doaj   +1 more source

Predictors of initiating biologics in the treatment of psoriasis. [PDF]

BACKGROUND Biologics are among the most effective therapies for psoriasis. However, many patients are only introduced to them at advanced stages of the disease course.
Cozzio, Antonio, Linnemann, Emilia, Maul, Julia-Tatjana, Maul, Lara Valeska, Yawalkar, Nikhil, Richter, Clara, Zink, Alexander, Dommann, Isabella, Schlapbach, Christoph, Kündig, Thomas, Navarini, Alexander, Conrad, Curdin, Egeberg, Alexander, Nielsen, Mia-Louise, Dommann, I., Zink, A., Schlapbach, Christoph; https://orcid.org/, Nielsen, M.L., Kündig, T., Nielsen, Mia‐Louise; https://orcid.org/, Conrad, Curdin; https://orcid.org/, Egeberg, A., Maul, Lara Valeska; https://orcid.org/, Yawalkar, N., Egeberg, Alexander; https://orcid.org/, Navarini, A., Dommann, Isabella; https://orcid.org/, Schlapbach, C., Kündig, Thomas; https://orcid.org/, Maul, Julia‐Tatjana; https://orcid.org/, Maul, L.V., Linnemann, E., Navarini, Alexander; https://orcid.org/, Yawalkar, Nikhil; https://orcid.org/, Maul, J.T., Conrad, C., Cozzio, A., Richter, C.   +37 more
core   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source