Results 131 to 140 of about 135,075 (307)

1339 Systemically administered onco-selective mRNA LNP achieves tumor regression and improves overall survival, as monotherapy

Journal for ImmunoTherapy of Cancer, 2023
Manfred Kraus, Aniela Jakubowski, Yulia Rybakova, Nicole Lessard, Rudy Christmas, Tom Addison, Leona Lee, Jieni Xu, Mark Krimmer, Cafer Ozdemir, Burak Yilmaz, Yusuf Erkul, Isaak Mueller   +12 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

FEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual, Marta Navarro‐Gutiérrez, Verónica Romero‐Albillo, Raquel Jiménez‐Sánchez   +3 more
wiley   +1 more source

Modular generation of multispecific antibodies using protein trans-splicing

mAbs
Multispecific antibodies are exhibiting rapid growth in drug development due to their ability to engage multiple therapeutic targets and deliver unique functional properties inaccessible to conventional monoclonal antibodies.
Jared A. Shadish, John D. Bagert, Amber N. Lee, Kenneth K. Sharp, Chunning Yang, Yijia Li, Rui Wang, Seungwook Shin, Alina A. Malik, Jia Lin, Fengying Huang, Wenhai Liu, Yariv Mazor   +12 more
doaj   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Immunogenicity overview of therapeutic biologics

, 2017
<p>Hello, everyone. Welcome to watch the video named immunogenicity overview of therapeutic biologics which created by creative biolabs. In this video, we will introduce the definition of immunogenicity, background of immunogenicity and importance ...
Creative Biolabs
core   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

‘Biological Signals’ to ‘Biological Signals and Receptors’

Neurosignals, 1998
Pang, SF, Ward, PA, Cardinali, DP
openaire   +4 more sources

Biological Dictionary

Zeitschrift für Naturforschung C, 1975
Abstract It is proposed that the biological communication is a language process with the basic word structure formed as a hexagonal neighborhood on the α-helix region of protein molecules.
openaire   +2 more sources

A fully human afucosylated anti-GARP antibody PBA-0111 drives anti-tumor immunity through combined ADCC induction and TGF-β1 pathway blockade

Frontiers in Immunology
MethodsWe have evaluated PBA-0111, a fully human antibody targeting Glycoprotein A Repetitions Predominant (GARP), designed to induce both antibody-dependent cellular cytotoxicity (ADCC) as well as blockage of Transforming Growth Factor Beta 1 (TGF-β1 ...
Pieter Spee, Monika Litwin, Damian Trojanowski, Connor Burns, Adrianna Dudek, Elżbieta Gołdyn, Kamilla Sołtys, Michał Sobecki, Aleksandra Świderska, Irwin Matyjaszczyk, Marek Orłowski, Marek Orłowski, Piotr Mamczur, Robert Kolodziejczyk, Dmytro Piliuhin, Jiaming Xu, Ewelina Krzywińska, Sameer Deshmukh, Tomasz Klaus, Ewelina Świderek, Kate Gillespie, Atticus Turner, Wendy Jenkins, Jason Frazier, Kenneth R. Gundle, John Weinberg, Niina Veitonmäki   +26 more
doaj   +1 more source