Results 231 to 240 of about 135,075 (307)

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Update on biologic and small molecules treatments in pediatric allergic diseases. [PDF]

Pediatr Allergy Immunol
den Dekker HT, Chauveau AD, Sterling B, Coopman S, Chinthrajah RS, Lejeune S, Holter D, Eiwegger T, Mallet S, Pijnenburg MW, Deschildre A.   +10 more
europepmc   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Biosimilar use in medical oncology in Ireland: a missed opportunity to mitigate financial toxicity? [PDF]

Int J Clin Pharm
Burton E, Coakley KE, Gaynor S, McDonagh M, Palmer C, Sahm LJ, O'Reilly S, Biologics Impact on Patient Care and Treatment (Bio ImPAcT) Consortium.   +7 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Adverse Reactions Identified after Approval of Novel Medicines: Analysis of 339 New Molecular Entities and Therapeutic Biologics. [PDF]

Clin Pharmacol Ther
Pinnow E, Day B, Zhou EH, Woods C, Dwumfour N, Lee JY, Bulatao I, Cherkaoui S, Kalaria M, Brajovic S, Sadiq N, Sistani F, Lee M, Chai G, Dal Pan G.   +14 more
europepmc   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Incident psoriasis in atopic dermatitis: a large-scale cohort study of disease- and treatment-associated risks. [PDF]

Front Immunol
Thaqi F, Bieber K, Kerniss H, Kridin K, Curman P, Ludwig RJ.   +5 more
europepmc   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Biologics in pediatric chronic rhinosinusitis with nasal polyps: A systematic review of efficacy and safety. [PDF]

Pediatr Allergy Immunol
Loperfido A, Anzivino R, Galletti C, Moffa A, Stivalini D, La Mantia I, De Corso E.   +6 more
europepmc   +1 more source