Results 91 to 100 of about 9,228,169 (408)
FEBS Letters, EarlyView.This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao +7 more
wiley +1 more source
Second To The Right, Straight On \u27Til Morning [PDF]
, 2007 A response to Michael Ruse\u27s Bare-Knuckle Fighting: EvoDevo Versus Natural Selection
Gilbert, Scott F.
core +1 more source
Single‐cell insights into the role of T cells in B‐cell malignancies
FEBS Letters, EarlyView.Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley +1 more source
Is synthetic biology mechanical biology?
History and Philosophy of the Life Sciences, 2015 A widespread and influential characterization of synthetic biology emphasizes that synthetic biology is the application of engineering principles to living systems. Furthermore, there is a strong tendency to express the engineering approach to organisms in terms of what seems to be an ontological claim: organisms are machines.
openaire +4 more sources
Arbor, 2007 La biología se ha convertido en la nueva “física” de las matemáticas, una de las áreas con mayores aplicaciones. Las matemáticas, por su parte, han proporcionado herramientas y metáforas muy poderosas para abordar la increíble complejidad de los sistemas biológicos. Esto ha permitido la génesis de marcos conceptuales sólidos.
openaire +6 more sources
Cancer Management and ResearchXiangnan Zhou,1,2,* Xiuhua Hu,2,3,* Zhiying Zhang,2,* Shicheng Lin,2 Ximing Lin,2 Tian Zhou,2 Yanping Bai,1 Kaiwen Hu2 1Department of Dermatology, China-Japan Friendship Hospital, National Center for Integrated Traditional Chinese
Zhou X +7 more
doaj
Health Fetishism Among The Nacirema: A Fugue On Jenny Reardon’s The Postgenomic Condition: Ethics, Justice, and Knowledge After The Genome (Chicago University Press, 2017) And Isabelle Stengers’ Another Science Is Possible: A Manifesto For Slow Science (Polity Press, 2018) [PDF]
, 2018 Personalized medicine has become a goal of genomics and of health policy makers. This article reviews two recent books that are highly critical of this approach, finding their arguments very thoughtful and important. According to Stengers, biology’s rush
Gilbert, Scott F.
core +2 more sources
Surprisingly Little Population Genetic Structure In A Fungus-Associated Beetle Despite Its Exploitation Of Multiple Hosts [PDF]
, 2013 In heterogeneous environments, landscape features directly affect the structure of genetic variation among populations by functioning as barriers to gene flow.
Brodie, E. D., III +3 more
core +2 more sources
FEBS Letters, EarlyView.In the adult T‐cell leukemia/lymphoma (ATL) cell line ED, the human T‐cell leukemia virus type 1 (HTLV‐1) provirus was integrated into the intron of the ift81 gene in the antisense orientation. Despite this integration, both the intact ift81 and the viral oncogene hbz were simultaneously expressed, likely due to the functional insufficiency of viral ...
Mayuko Yagi +5 more
wiley +1 more source
Biologie statistique / Statistical biology [PDF]
L’annuaire du Collège de France, 2020 Recherche Page web : https://www.college-de-france.fr/site/en-cirb/rivoire.htm. Notre equipe cherche a comprendre les principes sous-jacents aux capacites d’adaptation des systemes biologiques. Notre approche est inspiree de la physique statistique et combine des analyses de sequences genomiques, des experiences quantitatives in vitro et des modeles ...
openaire +4 more sources