Results 61 to 70 of about 3,613,281 (296)

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Biology

, 2000
Versión del ...
Afonso, E., Arnal-Atarés, J.I. (José Ignacio), Arrontes, J., Arzel, P., Augris, C., Belin, C., Belscher, T., Besteiro, C., Blanchard, M., Bocquéné, G., Bode, A. (Antonio), Borges, F., Borges, L., Brito, P., Burgeot, T. (Thierry), Cabanas-López, J.M. (José Manuel), Cardador, F. (Fátima), Cárdenas-González, E. (Enrique) de, Carrera, P. (Pablo), Catherine, M., Cavaco, H., Chapelle, Collet, A., Corral-Estrada, J. (Jerónimo), Duguy, R., Erard-Le-Denn, E. (Evelyne), Ferreira, A.M., Fonseca, P., Fumega, J. (José), Galgani, F. (François), Gaudêncio, M.J., Goraguer, M.A., Guérault, D., Guerra, M., Herbland, His, E., Lebre, M., Lens, S. (Santiago), Mauvais, J.L., Menésguen, A., Merceron, A., Mesnil, Michel, X., Moguedet, Ph. (Philippe), Moita, T., Monbet, Y., Morgado, C., Muñoz, G., Narbonne, J.F., Nunes, T. (Teresa), Olaso-Toca, L.I. (Luis Ignacio), Orive, E., Ortiz-de-Zárate, V. (Victoria), Palma, A.S., Pestana, G. (Graça), Pissarra, J. (Joaquim), Poulard, J.C., Quéro, J.C., Ramos, F. (Fernando), Reguera, B. (Beatriz), Rodríguez-de-León, A. (Argeo), Ruano, F., Salinas-Morrondo, J.M. (Juan Manuel), Sampayo, M.A., Sánchez-Delgado, F. (Francisco), Santiago-Fierro, G. (Guillermo) de, Santos, Sautor, B., Sobrino, I. (Ignacio), Valdés-Santurio, L. (Luis), Vale, C. (Carlos), Varela-Rodríguez, M. (Manuel), Vieites, J.M. (Juan Manuel), Villora, S.   +73 more
openaire   +2 more sources

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

FEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang, Frans Bianchi, Geert van den Bogaart   +2 more
wiley   +1 more source

Acknowledgement to Reviewers of Biology in 2014

Biology, 2015
The editors of Biology would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2014:[...]
Biology Editorial Office
doaj   +1 more source

A stepwise emergence of evolution in the RNA world

FEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

Acknowledgement to Reviewers of Biology in 2013

Biology, 2014
The editors of Biology would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2013.
Biology Editorial Office
doaj   +1 more source

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source

Correction: Environmental pollution is associated with increased risk of psychiatric disorders in the US and Denmark.

PLoS Biology, 2019
[This corrects the article DOI: 10.1371/journal.pbio.3000353.].
PLOS Biology Staff
doaj   +1 more source

Biology and Mathematics

Arbor, 2007
La biología se ha convertido en la nueva “física” de las matemáticas, una de las áreas con mayores aplicaciones. Las matemáticas, por su parte, han proporcionado herramientas y metáforas muy poderosas para abordar la increíble complejidad de los sistemas biológicos. Esto ha permitido la génesis de marcos conceptuales sólidos.
openaire   +6 more sources

The carboxylate “gripper” of the substrate is critical for C‐4 stereo‐inversion by UDP‐glucuronic acid 4‐epimerase

FEBS Letters, EarlyView.
UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg, Laura De Cnop, Bernd Nidetzky   +2 more
wiley   +1 more source