Results 91 to 100 of about 4,098,348 (323)
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
IET Systems BiologyWith the development of high‐throughput sequencing technology, the analysis of single‐cell RNA sequencing data has become the focus of current research.
Gong Lejun +4 more
doaj +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Neuromorphic computing using non-volatile memory
, 2017 Dense crossbar arrays of non-volatile memory (NVM) devices represent one possible path for implementing massively-parallel and highly energy-efficient neuromorphic computing systems.
G. Burr +16 more
semanticscholar +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Brief history of natural sciences for nature-inspired computing in engineering
Journal of Civil Engineering and Management, 2016 The goal of the authors is adroit integration of three mainstream disciplines of the natural sciences, physics, chemistry and biology to create novel problem solving paradigms.
Nazmul Siddique, Hojjat Adeli
doaj +1 more source
Living journal of computational molecular science, 2019 1Department of Chemical and Biomolecular Engineering, The University of Notre Dame; 2Thermodynamics Research Center, National Institute of Standards and Technology; 3Chemical Engineering Department, Brigham Young University; 4Laboratory of Computational ...
E. Maginn +5 more
semanticscholar +1 more source
Herbert Simon (1916-2001). The scientist of the artificial [PDF]
, 2001 With the disappearance of Herbert A. Simon, we have lost one of the most original thinkers of the 20th century. Highly influential in a number of scientific fields—some of which he actually helped create, such as artificial intelligence or information ...
Gobet, F
core
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Molecular Computing and Bioinformatics
Molecules, 2019 Molecular computing and bioinformatics are two important interdisciplinary sciences that study molecules and computers. Molecular computing is a branch of computing that uses DNA, biochemistry, and molecular biology hardware, instead of traditional ...
Xin Liang, Wen Zhu, Zhibin Lv, Quan Zou
doaj +1 more source