Results 91 to 100 of about 657,944 (323)
Hierarchical Access System for Sequence Libraries in Europe (HASSLE): a tool to access sequence databases remotely [PDF]
, 2017 Sequence databases in biology are growing exponentially. Not only are large sites needed to keep the data, but the number of customers is continuously increasing. Network access plays a key role in utilizing remote resources.
Doelz, R.
core
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
West-Life: A Virtual Research Environment for structural biology
Journal of Structural Biology: X, 2019 The West-Life project (https://about.west-life.eu/) is a Horizon 2020 project funded by the European Commission to provide data processing and data management services for the international community of structural biologists, and in particular to support
Chris Morris +30 more
doaj +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
HEPS scientific computing platform design for interactive data analysis scenarios [PDF]
EPJ Web of ConferencesThe High Energy Photon Source (HEPS), located at Beijing HuaiRou, is an advanced public platform for multidisciplinary innovation research and high-tech development, as well as understanding many scientific questions in the fields of physics, chemistry ...
Hu Qingbao +5 more
doaj +1 more source
Cloud and heterogeneous computing solutions exist today for the emerging big data problems in biology [PDF]
, 2011 Eric E. Schadt +4 more
openalex +1 more source
Quantum computing algorithms: getting closer to critical problems in computational biology [PDF]
, 2022 Laura Marchetti +8 more
openalex +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source