Results 91 to 100 of about 181,612 (311)

The rise of computational biology

Nature Reviews Molecular Cell Biology, 2002
The year 2001 saw a remarkable burst of interest in biological simulation, with several international meetings on the subject, and the inclusion, by journals, of web site references from which published models can be downloaded. So, why has all this happened so suddenly?
openaire   +4 more sources

MapReduce in Computational Biology - A Synopsis [PDF]

, 2017
In the past 20 years, the Life Sciences have witnessed a paradigm shift in the way research is performed. Indeed, the computational part of biological and clinical studies has become central or is becoming so. Correspondingly, the amount of data that one needs to process, compare and analyze, has experienced an exponential growth.
CATTANEO, Giuseppe, GIANCARLO, Raffaele, PIOTTO PIOTTO, Stefano, Petrillo, Umberto Ferraro, ROSCIGNO, GIANLUCA, DI BIASI, LUIGI   +5 more
openaire   +3 more sources

Virtual living organism: A rapid prototyping tool to emulate biology [PDF]

, 2011
Rapid prototyping tools exist in many fields of science and engineering, but are rare in biology especially not general tools that can handle the diversity and complexity of the many spatial and temporal scales in nature.
Bándi, Gergely
core  

Graphical Modelling Tools for Systems Biology [PDF]

, 2014
Modeling biological systems to understand their mechanistic behavior is an important activity in molecular systems biology. Mathematical modeling typically requires deep mathematical or computing knowledge, and this limits the spread of modeling tools ...
R. Gostner, B. Baldacci, C. Priami, M. J. Morine   +3 more
core   +1 more source

SeqBMC: Single‐cell data processing using iterative block matrix completion algorithm based on matrix factorisation

IET Systems Biology
With the development of high‐throughput sequencing technology, the analysis of single‐cell RNA sequencing data has become the focus of current research.
Gong Lejun, Yu Like, Wei Xinyi, Zhou Shehai, Xu Shuhua   +4 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Limits of computational biology

In Silico Biology, 2015
Abstract Are we close to a complete inventory of living processes so that we might expect in the near future to reproduce every essential aspect necessary for life? Or are there mechanisms and processes in cells and organisms that are presently inaccessible to us?
openaire   +3 more sources

Computational Biology and High Performance Computing 2000 [PDF]

, 2000
The pace of extraordinary advances in molecular biology has accelerated in the past decade due in large part to discoveries coming from genome projects on human and model organisms.
Simon, Horst D., Spengler, Sylvia J., Stewart, Craig A., Zorn, Manfred D., Stewart, Craig, Dubchak, Inna L., Arkin, Adam P., Shoichet, Brian K.   +7 more
core  

Computing nature: turing centenary perspective [PDF]

, 2013
This book is about nature considered as the totality of physical existence, the universe, and our present day attempts to understand it. If we see the universe as a network of networks of computational processes at many different levels of organization ...
Dodig Crnkovic, Gordana, Dodig-Crncovic, Gordana, Dodig Crnkovic, Gordana,, Giovagnoli, Raffaela, Giovagnoli, Raffaela,, Dodig-Crnkovic, Gordana, Dodig-Crnkovic, Gordana,, Giovagnoli, Rafaela   +7 more
core   +2 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source