Results 141 to 150 of about 181,612 (311)
IET Systems BiologyPredicting the combined score in protein–protein interaction (PPI) networks represents a critical research focus in bioinformatics, as it contributes to enhancing the accuracy of PPI data and uncovering the inherent complexity of biological systems ...
Sicong Huo +5 more
doaj +1 more source
BMC Bioinformatics, 2019 Between June 9–11, 2019, the International Conference on Intelligent Biology and Medicine (ICIBM 2019) was held in Columbus, Ohio, USA. The conference included 12 scientific sessions, five tutorials or workshops, one poster session, four keynote talks ...
Zhongming Zhao +5 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Viewpoints from Computing to the Epistemology of Experiments [PDF]
, 2013 Although experiments have been a core element of the scientific method since the 1600s, experiments per se only caught philosophers' interest in the 1980s.
Moisseinen, Nella +2 more
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IET Systems BiologyAccumulating evidence suggests that the TP53 mutation, intratumoral microbiome, and tumour microenvironment (TME) are closely linked to tumourigenesis, yet the biological mechanisms underlying these connections remain unclear.
Baoling Wang, Bo Zhang, Chun Li
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Eurographics Workshop on Visual Computing for Biology and Medicine: Short Papers Frontmatter [PDF]
Eurographics Workshop on Visual Computing for Biology and ...
Garrison, Laura, Krueger, Robert
core +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
An Implementation of the Python Code for Computing the Independent Number of Genus Graphs
MathematicsThe computation of the independent number is a fundamental problem in graph theory. It has many applications, including route planning, computer graphics, network analysis, computational biology, and network architecture.
Sana Anjum, Amal S. Alali
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source