Results 121 to 130 of about 181,612 (311)
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Computing resources sensitive parallelization of neural neworks for large scale diabetes data modelling, diagnosis and prediction [PDF]
, 2011 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Diabetes has become one of the most severe deceases due to an increasing number of diabetes patients globally.
Qi, Hao
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A case study in model-driven synthetic biology [PDF]
, 2008 We report on a case study in synthetic biology, demonstrating the modeldriven design of a self-powering electrochemical biosensor. An essential result of the design process is a general template of a biosensor, which can be instantiated to be adapted ...
Heiner, M. +18 more
core +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Distributed computing inspired by biology [PDF]
International audienceBiological systems are mastering the art of composing cells into colonies, tissues, and organisms. This article reviews striking similarities and differences between such biological systems and distributed computing systems, where ...
Thuillier, Kerian +2 more
core +1 more source
RBioCloud : a light-weight framework for bioconductor and R-based jobs on the Cloud [PDF]
, 2014 Large-scale ad hoc analytics of genomic data is popular using the R-programming language supported by over 700 software packages provided by Bioconductor.
Barker, Adam David +5 more
core +1 more source
Pathways to cellular supremacy in biocomputing
Nature Communications, 2019 Synthetic biology uses cells as its computing substrate, often based on the genetic circuit concept. In this Perspective, the authors argue that existing synthetic biology approaches based on classical models of computation limit the potential of ...
Lewis Grozinger +9 more
doaj +1 more source
BMC Bioinformatics, 2018 The 2018 International Conference on Intelligent Biology and Medicine (ICIBM 2018) was held on June 10–12, 2018, in Los Angeles, California, USA. The conference consisted of a total of eleven scientific sessions, four tutorials, one poster session, four ...
Xiaoming Liu +6 more
doaj +1 more source
FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source
Ubiquitous computing in the biology laboratory [PDF]
, 2001 Our objective is to eliminate the barriers that currently inhibit broader and deeper application of computing technology toward the advancement of molecular biology.
Bob Franza Md, Stefan Sigdursson
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