Results 71 to 80 of about 657,944 (323)

DNA Encoding Optimisation Based on Thermodynamics

CAAI Transactions on Intelligence Technology
Due to their exceptional programmability, DNA molecules are widely employed in the design of molecular circuits for applications such as DNA computing, DNA storage and cancer diagnosis and treatment.
Xianhang Luo, Kai Zhang, Enqiang Zhu, Jin Xu   +3 more
doaj   +1 more source

Information Compression, Intelligence, Computing, and Mathematics [PDF]

, 2015
This paper presents evidence for the idea that much of artificial intelligence, human perception and cognition, mainstream computing, and mathematics, may be understood as compression of information via the matching and unification of patterns.
Wolff, J. Gerard
core  

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

StackAHTPs: An explainable antihypertensive peptides identifier based on heterogeneous features and stacked learning approach

IET Systems Biology
Hypertension, often known as high blood pressure, is a major concern to millions of individuals globally. Recent studies have demonstrated the significant efficacy of naturally derived peptides in reducing blood pressure. Hypertension is one of the risks
Ali Ghulam, Muhammad Arif, Ahsanullah Unar, Maha A. Thafar, Somayah Albaradei, Apilak Worachartcheewan   +5 more
doaj   +1 more source

Applied GPU Computing in Computational Biology to Study Disparate Multicellularity Scenarios v2 [PDF]

, 2022
Avimanyu Bandyopadhyay
openalex   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

SeqBMC: Single‐cell data processing using iterative block matrix completion algorithm based on matrix factorisation

IET Systems Biology
With the development of high‐throughput sequencing technology, the analysis of single‐cell RNA sequencing data has become the focus of current research.
Gong Lejun, Yu Like, Wei Xinyi, Zhou Shehai, Xu Shuhua   +4 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Brief history of natural sciences for nature-inspired computing in engineering

Journal of Civil Engineering and Management, 2016
The goal of the authors is adroit integration of three mainstream disciplines of the natural sciences, physics, chemistry and biology to create novel problem solving paradigms.
Nazmul Siddique, Hojjat Adeli
doaj   +1 more source