The contrast transfer function (CTF) is an imaging aberration that is a major resolution‐limiting factor in cryo‐electron microscopy (cryo‐EM). Precise CTF estimation is key to overcoming this limitation, but is particularly challenging in cryo‐electron tomography (cryo‐ET) data. Here, we present an approach for using geometric information to assist in
Sagar Khavnekar, William Wan
wiley +1 more source
Macromolecular crystallography and biology at the Linac Coherent Light Source. [PDF]
Mous S+4 more
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Development of 4T1 breast cancer mouse model system for preclinical carbonic anhydrase IX studies
Carbonic anhydrase IX (CAIX) is a well‐recognised therapeutic target and prognostic biomarker in cancer. We developed and characterised a robust murine breast cancer model system that is suitable for CAIX studies in vitro and in vivo—it comprises both CAIX‐positive and CAIX‐negative controls and provides a solid platform for the comprehensive ...
Zane Kalniņa+13 more
wiley +1 more source
Training young scientist on biochemistry and molecular biology methods in the laboratory. Training young scientist on experimental methods for studying YAP/TEAD and NFkB.
openaire +1 more source
Mitochondria contain two mitoribosome rescue factors, ICT1 and MTRFR (C12orf65). ICT1 also functions as a mitoribosomal protein in mice and humans, and its loss is lethal. Although Mtrfr knockout mice could not be generated, knockout zebrafish lines for ict1 and mtrfr were established.
Nobukazu Nameki+11 more
wiley +1 more source
Expanding kinetoplastid genome annotation through protein structure comparison. [PDF]
Trinidad-Barnech JM+3 more
europepmc +1 more source
Overexpression of LINC00672 promotes autophagy in Alzheimer's disease by upregulating GPNMB. [PDF]
Gao L, Hu S, Lv Y, Zheng G, Lin Z.
europepmc +1 more source
Minocycline inhibits rosacea-like inflammation through the TLR4-mediated NF-κB signaling pathway in vivo and in vitro. [PDF]
Hua P+6 more
europepmc +1 more source
New Insights into Nuclear Magnetic Resonance (NMR) Spectroscopy. [PDF]
Gerothanassis IP, Kupka T.
europepmc +1 more source
Correction: Population structure, genetic diversity, and GWAS analyses with GBS-derived SNPs and silicodart markers unveil genetic potential for breeding and candidate genes for agronomic and root quality traits in an international sugar beet germplasm collection. [PDF]
Bahjat NM+12 more
europepmc +1 more source