Results 1 to 10 of about 430,909 (261)

An avian embryo patient-derived xenograft model for preclinical studies of human breast cancers

iScience, 2021
Summary: Lack of preclinical patient-derived xenograft cancer models in which to conduct large-scale molecular studies seriously impairs the development of effective personalized therapies. We report here an in vivo concept consisting of implanting human
Loraine Jarrosson, Clélia Costechareyre, Fanny Gallix, Séverine Ciré, Fabien Gay, Olivier Imbaud, Romain Teinturier, Elisabetta Marangoni, Karine Aguéra, Céline Delloye-Bourgeois, Valérie Castellani   +10 more
doaj   +1 more source

A new murine esophageal organoid culture method and organoid-based model of esophageal squamous cell neoplasia

iScience, 2021
Summary: Organoids mimic the physiologic and pathologic events of organs. However, no consensus on esophageal organoid (EO) culture methods has been reached.
Biyun Zheng, Kyung-Pil Ko, Xuefen Fang, Xiaozhong Wang, Jie Zhang, Sohee Jun, Bong-Jun Kim, Wenyi Luo, Moon Jong Kim, Youn-Sang Jung, Christopher L. Cervantes, Jae-Il Park   +11 more
doaj   +1 more source

Higher Education Research in Scotland: Report of a Survey Undertaken by Universities Scotland Educational Development Sub-Committee [PDF]

, 2012
The aim of this study was to gain an insight into a range of higher educational research taking place across Scotland with a particular focus on the nature, expertise, support and dissemination of this research.
Bovill, C., Sheward, L., Smyth, K.
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The Risk of Cancer from CT Scans and Other Sources of Low-Dose Radiation: A Critical Appraisal of Methodologic Quality [PDF]

, 2020
Introduction: Concern exists that radiation exposure from computerized tomography (CT) will cause thousands of malignancies. Other experts share the same perspective regarding the risk from additional sources of low-dose ionizing radiation ...
Doss, Mohan, PhD, Fairley, Romeo, MD, Murphy, Linda Suk-Ling, Schultz, Carl H, MD   +3 more
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The role of Computer Aided Process Engineering in physiology and clinical medicine [PDF]

, 2009
This paper discusses the potential role for Computer Aided Process Engineering (CAPE) in developing engineering analysis and design approaches to biological systems across multiple levels—cell signalling networks, gene, protein and metabolic networks ...
Allen, R., Bogle, I.D.L., Sumner, T.
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High-throughput submicron-resolution microscopy of Caenorhabditis elegans populations under strong immobilization by cooling cultivation plates

iScience, 2023
Summary: Despite its profound impact on biology, high-resolution in vivo microscopy largely remains low throughput because current immobilization techniques require substantial manual effort.
Yao L. Wang, Noa W.F. Grooms, Erik L. Jaklitsch, Leilani G. Schulting, Samuel H. Chung   +4 more
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Editorial Special Issue on Enhancement Algorithms, Methodologies and Technology for Spectral Sensing [PDF]

, 2010
The paper is an editorial issue on enhancement algorithms, methodologies and technology for spectral sensing and serves as a valuable and useful reference for researchers and technologists interested in the evolving state-of-the-art and/or the emerging ...
Gillespie, Patti, Gupta, Neelam, Hayat, Majeed M., Jensen, James O., Li, Yanqiu, Theriault, Jean-Marc, Trew, Robert J., Woolard, Dwight L.   +7 more
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Helping Business Schools Engage with Real Problems: The Contribution of Critical Realism and Systems Thinking [PDF]

, 2015
The world faces major problems, not least climate change and the financial crisis, and business schools have been criticised for their failure to help address these issues and, in the case of the financial meltdown, for being causally implicated in it ...
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Artificial nondirectional site-specific recombination systems

iScience, 2022
Summary: Site-specific recombination systems (SRSs) are widely used in studies on synthetic biology and related disciplines. Nondirectional SRSs can randomly trigger excision, integration, reversal, and translocation, which are effective tools to achieve
Jun-Yi Wang, Yue-Yang Cao, Ya-Nan Chen, Xiao-Le Wu, Bo-Tao He, Si-Yu Zhu, Xiao Zhou, Yi Wu, Bing-Zhi Li, Ying-Jin Yuan   +9 more
doaj   +1 more source

Caged-carvedilol as a new tool for visible-light photopharmacology of β-adrenoceptors in native tissues

iScience, 2022
Summary: Adrenoceptors are G protein-coupled receptors involved in a large variety of physiological processes, also under pathological conditions. This is due in large part to their ubiquitous expression in the body exerting numerous essential functions.
Anna Duran-Corbera, Joan Font, Melissa Faria, Eva Prats, Marta Consegal, Juanlo Catena, Lourdes Muñoz, Demetrio Raldua, Antonio Rodriguez-Sinovas, Amadeu Llebaria, Xavier Rovira   +10 more
doaj   +1 more source