Results 31 to 40 of about 111,792 (265)

Direct capture and sequencing reveal ultra-short single-stranded DNA in biofluids

iScience, 2022
Summary: Cell-free DNA (cfDNA) has become the predominant analyte of liquid biopsy; however, recent studies suggest the presence of subnucleosomal-sized DNA fragments in circulation that are likely single-stranded.
Lauren Y. Cheng, Peng Dai, Lucia R. Wu, Abhijit A. Patel, David Yu Zhang   +4 more
doaj   +1 more source

New directions for the treatment of adrenal insufficiency [PDF]

, 2015
The following funding bodies supported this work: Biotechnology and Biological Sciences Research Council (BBSRC BB/L00267/1, to LG), Rosetrees Trust (to LG), Barts and The London Charity (417/2235, to LG), EU COFUND (PCOFUND-GA-2013-608765, to LG and GRB)
Leonardo Guasti, Hadjidemetriou, I, Guasti, L, Leonardo eGuasti, Gerard Ruiz-Babot, Ruiz-Babot, G, Irene eHadjidemetriou, Irene Hadjidemetriou, Peter James King, Gerard eRuiz-Babot, King, PJ   +10 more
core   +1 more source

Super-multiplex imaging of cellular dynamics and heterogeneity by integrated stimulated Raman and fluorescence microscopy

iScience, 2021
Summary: Observing multiple molecular species simultaneously with high spatiotemporal resolution is crucial for comprehensive understanding of complex, dynamic, and heterogeneous biological systems.
Jingwen Shou, Robert Oda, Fanghao Hu, Keiko Karasawa, Mutsuo Nuriya, Masato Yasui, Bruce Shiramizu, Wei Min, Yasuyuki Ozeki   +8 more
doaj   +1 more source

A non-invasive method to genotype cephalopod sex by quantitative PCR

iScience
Summary: Coleoid cephalopods (cuttlefish, octopus, and squid) are emerging model organisms in neuroscience, development, and evolutionary biology and are of major economic importance in global fisheries.
Frederick A. Rubino, Gabrielle C. Coffing, Connor J. Gibbons, Scott T. Small, Thomas Desvignes, Jeffrey Pessutti, Ann M. Petersen, Alexander Arkhipkin, Zhanna Shcherbich, John H. Postlethwait, Andrew D. Kern, Tessa G. Montague   +11 more
doaj   +1 more source

3D visualization of trans-syncytial nanopores provides a pathway for paracellular diffusion across the human placental syncytiotrophoblast

iScience, 2022
Summary: The placental syncytiotrophoblast, a syncytium without cell-cell junctions, is the primary barrier between the mother and the fetus. Despite no apparent anatomical pathway for paracellular diffusion of solutes across the syncytiotrophoblast ...
Rohan M. Lewis, Harikesan Baskaran, Jools Green, Stanimir Tashev, Eleni Palaiologou, Emma M. Lofthouse, Jane K. Cleal, Anton Page, David S. Chatelet, Patricia Goggin, Bram G. Sengers   +10 more
doaj   +1 more source

Nonredundant Raman imaging using optical eigenmodes [PDF]

, 2014
We thank funding from the UK Engineering and Physical Sciences Research Council namely grant EP/J01771X/1 and EU FP7 grant FAMOS.Various forms of imaging schemes have emerged over the last decade that are based on correlating variations in incident ...
Herrington, C. Simon, Herrington, C Simon, Kosmeier, Sebastian, Zolotovskaya, Svetlana A.; id_orcid, De Luca, Anna Chiara, Riches, Andrew C, Riches, Andrew, Zolotovskaya, Svetlana A., De Luca, Anna Ciara, Zolotovskaya, Svetlana, Dholakia, Kishan, Mazilu, Michael   +11 more
core   +1 more source

Mathematical model calibrated to in vitro data predicts mechanisms of antiviral action of the influenza defective interfering particle “OP7”

iScience
Summary: Defective interfering particles (DIPs) are regarded as potent broad-spectrum antivirals. We developed a mathematical model that describes intracellular co-infection dynamics of influenza standard virus (STV) and “OP7”, a new type of influenza ...
Daniel Rüdiger, Julita Piasecka, Jan Küchler, Carolina Pontes, Tanja Laske, Sascha Y. Kupke, Udo Reichl   +6 more
doaj   +1 more source

Immortalized human choroid plexus endothelial cells enable an advanced endothelial-epithelial two-cell type in vitro model of the choroid plexus

iScience, 2022
Summary: The choroid plexus (CP) is a highly vascularized structure containing endothelial and epithelial cells located in the ventricular system of the central nervous system (CNS).
Walter Muranyi, Christian Schwerk, Rosanna Herold, Carolin Stump-Guthier, Marko Lampe, Petra Fallier-Becker, Christel Weiß, Carsten Sticht, Hiroshi Ishikawa, Horst Schroten   +9 more
doaj   +1 more source

Application of software engineering methodologies to the development of mathematical biological models [PDF]

, 2013
Mathematical models have been used to capture the behaviour of biological systems, from low-level biochemical reactions to multi-scale whole-organ models.
Gill, Mandeep Singh
core   +2 more sources

A deepening understanding of animal culture suggests lessons for conservation [PDF]

, 2021
Funding and support as follows: Whale and Dolphin Conservation to P.B.; Royal Society New Zealand Rutherford Discovery Fellowship to E.L.C; Radcliffe Fellowship, Radcliffe Institute for Advanced Study, Harvard University, and Biotechnology and Biological
Bearhop, Stuart, Mesnick, Sarah, Dall, S.R.X., Keith, S., Whithead, Hal, Robbins, M.M., Keith, S.A., Noad, Michael, Robbins, M. ; https://orcid.org/, Garland, Ellen C., Simmonds, M.P., Notarbartolo di Sciara, Giuseppe, Spina, F., Whiten, Andrew, Williams, James, Brakes, Philippa, Dall, Sasha R X, Whitehead, Hal, Sciara Di, Giuseppe Notarbartolo, Wade, Paul, Notarbartolo di Sciara, G., Whiting, Martin, Brakes, P., Rendell, L., Rendell, Luke Edward, Carroll, Emma L., Wade, P.R., Noad, M., Keith, Sally Anne, Wade, P., Thornton, A., Thornton, Alex, Ford, J.K.B., Carroll, E., Thorton, Alex, Williams, J., McGregor, Peter, Robbins, Martha M., Ciucci, P., Mesnick, S.L., Aplin, Lucy M., Fishlock, V., Mesnick, Sarah L., Ford, John, Dall, Sasha, Dall, S., Simmonds, M., Noad, M.J., Mesnick, S., Rutz, Christian, Fishlock, Vicki, Keith, Sally A., Simmonds, Mark P., McGregor, Peter K., Keith, Sally, Garland, E., Aplin, Lucy, Noad, Michael J., Whiting, Martin J., Dall, Sasha R. X., Whiting, M.J., Whiten, A., Rendell, Luke, Aplin, L., Simmonds, Mark, McGregor, P., Robbins, M., Aplin, L.M., Bearhop, S., Whiting, M., Whitehead, H., Ford, John K. B., Robbins, Martha, Carroll, Emma L, Ford, J., Spina, Fernando, Carroll, E.L., Ciucci, Paolo, Garland, E.C., Wade, Paul R., McGregor, P.K., Rutz, C.   +81 more
core   +1 more source