Results 31 to 40 of about 430,909 (261)

Scope and financial impact of unpublished data and unused samples among U.S. academic and government researchers

iScience, 2023
Summary: Unpublished data and unused samples are common byproducts of research activity, but little is known about the scope and economic impact of their disuse.
Emma C. Bowers, Jimena Stephenson, Melissa Furlong, Kenneth S. Ramos   +3 more
doaj   +1 more source

Precision vibratome for high-speed ultrathin biotissue cutting and organ-wide imaging

iScience, 2021
Summary: Cutting tissues into ultrathin slices is highly desired in sectioning-based organ-wide imaging. However, it is difficult to perform tissue cutting at a high speed with excellent quality.
Yafeng Li, Zhangheng Ding, Lei Deng, Guoqing Fan, Qi Zhang, Hui Gong, Anan Li, Jing Yuan, Jianwei Chen   +8 more
doaj   +1 more source

A light-switching pyrene probe to detect phase-separated biomolecules

iScience, 2021
Summary: Biomolecules may undergo liquid–liquid phase separation (LLPS) to spatiotemporally compartmentalize and regulate diverse biological processes. Because the number of tools to directly probe LLPS is limited (ie. FRAP, FRET, fluorescence microscopy,
Masaharu Hazawa, Shogo Amemori, Yoshio Nishiyama, Yoshihiro Iga, Yuki Iwashima, Akiko Kobayashi, Hirohisa Nagatani, Motohiro Mizuno, Kenji Takahashi, Richard W. Wong   +9 more
doaj   +1 more source

Developing Predictive Molecular Maps of Human Disease through Community-based Modeling [PDF]

, 2011
The failure of biology to identify the molecular causes of disease has led to disappointment in the rate of development of new medicines. By combining the power of community-based modeling with broad access to large datasets on a platform that promotes ...
Christine Suver, David Henderson, Jonathan Derry, Jonathan Derry, Jonathan Izant, Lara Mangravite, Matt Furia, Michael Kellen, Solveig Sieberts, Stephen Friend, Xavier Schildwachter   +10 more
core   +2 more sources

Multiplexed protein profiling reveals spatial subcellular signaling networks

iScience, 2022
Summary: Protein-protein interaction networks are altered in multi-gene dysregulations in many disorders. Image-based protein multiplexing sheds light on signaling pathways to dissect cell-to-cell heterogeneity, previously masked by the bulk assays ...
Shuangyi Cai, Thomas Hu, Mythreye Venkatesan, Mayar Allam, Frank Schneider, Suresh S. Ramalingam, Shi-Yong Sun, Ahmet F. Coskun   +7 more
doaj   +1 more source

Researching gender: the challenge of global diversity today [PDF]

, 2010
The text of this paper is based on a lecture given at the symposium of the Ghent African Platform “Researching Gender in/on Africa” at Ghent University in December 2009.
Longman, Chia
core   +3 more sources

SkewC: Identifying cells with skewed gene body coverage in single-cell RNA sequencing data

iScience, 2022
Summary: The analysis and interpretation of single-cell RNA sequencing (scRNA-seq) experiments are compromised by the presence of poor-quality cells. For meaningful analyses, such poor-quality cells should be excluded as they introduce noise in the data.
Imad Abugessaisa, Akira Hasegawa, Shuhei Noguchi, Melissa Cardon, Kazuhide Watanabe, Masataka Takahashi, Harukazu Suzuki, Shintaro Katayama, Juha Kere, Takeya Kasukawa   +9 more
doaj   +1 more source

Practice-oriented controversies and borrowed epistemic credibility in current evolutionary biology: phylogeography as a case study [PDF]

, 2013
Although there is increasing recognition that theory and practice in science are intimately intertwined, philosophy of science perspectives on scientific controversies have been historically focused on theory rather than practice.
Arroyo-Santos, Alfonso, Olson, Mark E., Vergara-Silva, Francisco   +2 more
core   +3 more sources

Environmental risk assessment of genetically modified plants - concepts and controversies [PDF]

, 2011
Background and purpose: In Europe, the EU Directive 2001/18/EC lays out the main provisions of environmental risk assessment (ERA) of genetically modified (GM) organisms that are interpreted very differently by different stakeholders. The purpose of this
A Hilbeck, A Hilbeck, A Hilbeck, A Hilbeck, A Hilbeck, A Hilbeck, A Lang, A Raps, A Raybould, A Raybould, AL Cerdeira, ANE Birch, B Lutz, C Hawes, C Zwahlen, C Zwahlen, CB Blackwood, CBD, Council of the European Union, D Saxena, DA Andow, DA Andow, DA Andow, DJ Baird, EC, EC, EFSA, EJ Rosi-Marshall, Environmental Protection Agency (EPA), EP Millstone, EPA Environmental Protection Agency OPPTS 7501P, EurActive, FAO/WHO, J Romeis, J Romeis, J Romeis, J Scheirs, JD Harwood, JD Harwood, KC Nelson, KC Nelson, KR Hayes, KR Hayes, LB Obrist, M Dolezel, M Douville, M Garcia-Alonso, M Mendelsohn, MC Arregui, MR Berenbaum, National Research Council (NRC), OECD, OECD (Organisation for Economic Cooperation and Development), PM Chapman, Royal Society of Canada, T Bøhn, VE Forbes, W Freese   +57 more
core   +1 more source