iScience, 2023 Summary: Metastatic lesions produced through the process of systemic tumor cell dissemination and growth at distant sites are challenging to treat and the primary cause of patient mortality.
Sumreen Javed +4 more
doaj +1 more source
Influence of data sampling methods on the representation of neural spiking activity in vivo
iScience, 2022 Summary: In vivo single-unit recordings distinguish the basal spiking properties of neurons in different experimental settings and disease states. Here, we examined over 300 spike trains recorded from Purkinje cells and cerebellar nuclei neurons to test ...
Meike E. van der Heijden +2 more
doaj +1 more source
The ex vivo pharmacology of HIV-1 antiretrovirals differs between macaques and humans
iScience, 2022 Summary: Non-human primates (NHP) are widely used for the pre-clinical assessment of antiretrovirals (ARVs) for HIV treatment and prevention. However, the utility of these models is questionable given the differences in ARV pharmacology between humans ...
Carolina Herrera +12 more
doaj +1 more source
Towards Convergence: How to Do Transdisciplinary Environmental Health Disparities Research. [PDF]
, 2020 Increasingly, funders (i.e., national, public funders, such as the National Institutes of Health and National Science Foundation in the U.S.) and scholars agree that single disciplines are ill equipped to study the pressing social, health, and ...
Cannon, Clare EB
core +1 more source
Integrative processing of untargeted metabolomic and lipidomic data using MultiABLER
iScience, 2023 Summary: Mass spectrometry (MS)-based untargeted metabolomic and lipidomic approaches are being used increasingly in biomedical research. The adoption and integration of these data are critical to the overall multi-omic toolkit.
Ian C.H. Lee +4 more
doaj +1 more source
Mapping-friendly sequence reductions: Going beyond homopolymer compression
iScience, 2022 Summary: Sequencing errors continue to pose algorithmic challenges to methods working with sequencing data. One of the simplest and most prevalent techniques for ameliorating the detrimental effects of homopolymer expansion/contraction errors present in ...
Luc Blassel, Paul Medvedev, Rayan Chikhi
doaj +1 more source
Acoustic camera system for measuring ultrasound communication in mice
iScience, 2022 Summary: To investigate biological mechanisms underlying social behaviors and their deficits, social communication via ultrasonic vocalizations (USVs) in mice has received considerable attention as a powerful experimental model.
Jumpei Matsumoto +7 more
doaj +1 more source
One health research in Northern Tanzania – challenges and progress [PDF]
, 2017 East Africa has one of the world’s fastest growing human populations—many of whom are dependent on livestock—as well as some of the world’s largest wildlife populations.
Allan, Kathryn J. +16 more
core +1 more source
Rapid fluorescent vital imaging of olfactory epithelium
iScience, 2022 Summary: Olfactory epithelium (OE) undergoes degeneration in disorders such as age-related and post-viral olfactory dysfunction. However, methods for real-time in vivo detection of OE and assessment of total extent within the nasal cavity are currently ...
Hironobu Nishijima +6 more
doaj +1 more source
Tris(2-pyridylmethyl)amine (TPA) as a membrane-permeable chelator for interception of biological mobile zinc [PDF]
, 2013 We report the characterization of tris(2-pyridylmethyl)amine (TPA) as a membrane-permeable zinc chelator for intercepting biological mobile zinc. Compared to N,N,N′,N′-tetrakis(2-pyridylmethyl)ethylenediamine (TPEN), TPA chelates zinc with faster ...
Bosch, Miquel +4 more
core +1 more source