Results 21 to 30 of about 111,792 (265)

"Positive" Results Increase Down the Hierarchy of the Sciences [PDF]

, 2010
The hypothesis of a Hierarchy of the Sciences with physical sciences at the top, social sciences at the bottom, and biological sciences in-between is nearly 200 years old.
Daniele Fanelli, Fanelli, D.; id_orcid, Fanelli Daniele, Fanelli, Daniele   +3 more
core   +1 more source

Scope and financial impact of unpublished data and unused samples among U.S. academic and government researchers

iScience, 2023
Summary: Unpublished data and unused samples are common byproducts of research activity, but little is known about the scope and economic impact of their disuse.
Emma C. Bowers, Jimena Stephenson, Melissa Furlong, Kenneth S. Ramos   +3 more
doaj   +1 more source

The effects of perceived stress on biological parameters in healthcare professionals: A systematic review. [PDF]

, 2014
We synthesised evidence on biological correlates of psychological stress in hospital-based healthcare professionals, and examined whether there was evidence of consistent biological changes.
Montgomery Anthony, Panagopoulou Efharis, Vedhara Kavita, Hackshaw Lucy, Dawe Karen, McGee Hannah, Morgan Hannah   +6 more
core   +1 more source

Precision vibratome for high-speed ultrathin biotissue cutting and organ-wide imaging

iScience, 2021
Summary: Cutting tissues into ultrathin slices is highly desired in sectioning-based organ-wide imaging. However, it is difficult to perform tissue cutting at a high speed with excellent quality.
Yafeng Li, Zhangheng Ding, Lei Deng, Guoqing Fan, Qi Zhang, Hui Gong, Anan Li, Jing Yuan, Jianwei Chen   +8 more
doaj   +1 more source

Multiplexed protein profiling reveals spatial subcellular signaling networks

iScience, 2022
Summary: Protein-protein interaction networks are altered in multi-gene dysregulations in many disorders. Image-based protein multiplexing sheds light on signaling pathways to dissect cell-to-cell heterogeneity, previously masked by the bulk assays ...
Shuangyi Cai, Thomas Hu, Mythreye Venkatesan, Mayar Allam, Frank Schneider, Suresh S. Ramalingam, Shi-Yong Sun, Ahmet F. Coskun   +7 more
doaj   +1 more source

SkewC: Identifying cells with skewed gene body coverage in single-cell RNA sequencing data

iScience, 2022
Summary: The analysis and interpretation of single-cell RNA sequencing (scRNA-seq) experiments are compromised by the presence of poor-quality cells. For meaningful analyses, such poor-quality cells should be excluded as they introduce noise in the data.
Imad Abugessaisa, Akira Hasegawa, Shuhei Noguchi, Melissa Cardon, Kazuhide Watanabe, Masataka Takahashi, Harukazu Suzuki, Shintaro Katayama, Juha Kere, Takeya Kasukawa   +9 more
doaj   +1 more source

e-science and the semantic web: A symbiotic relationship [PDF]

, 2006
e-Science is scientific investigation performed through distributed global collaborations between scientists and their resources, and the computing infrastructure that enables this. Scientific progress increasingly depends on pooling know-how and results;
De Roure, David, De Roure, D., Pinar Alper, Oscar Corcho, Corcho, Oscar, Alper, Pinar, Alper, P, Alper, P., Goble, CA, Roure, DD, David De Roure, Corcho, Ó, Goble, Carole A, Carole Goble, Roure, David De, Goble, Carole, Goble, C.   +16 more
core   +1 more source

Some factors influencing occupational engagement for people with schizophrenia living in the community [PDF]

, 2002
With the emergence of occupational science, there has been renewed interest in the health benefits of occupational engagement and a call for more research into the occupational nature of humans.
Chugg, A, Craik, C
core   +1 more source

Specificity and efficiency of tamoxifen-mediated Cre induction is equivalent regardless of age

iScience, 2023
Summary: Temporally controlling Cre recombination through tamoxifen (Tam) induction has many advantages for biomedical research. Most studies report early post-natal/juvenile (12 m.o.).
Collyn M. Kellogg, Kevin Pham, Sunghwan Ko, Jillian E.J. Cox, Adeline H. Machalinski, Michael B. Stout, Amanda L. Sharpe, Michael J. Beckstead, Ana J. Chucair-Elliott, Sarah R. Ocañas, Willard M. Freeman   +10 more
doaj   +1 more source