Results 11 to 20 of about 430,909 (261)

Circulating tumor cells: Towards mechanical phenotyping of metastasis

iScience, 2022
Summary: During cancer progression, metastatic dissemination accounts for ∼90% of death in patients. Metastasis occurs upon dissemination of circulating tumor cells (CTC) through body fluids, in particular the bloodstream, and several key steps remain ...
Marina Peralta, Naël Osmani, Jacky G. Goetz   +2 more
doaj   +3 more sources

Biological nanopores for single-molecule sensing

iScience, 2022
Summary: Evolution has found countless ways to transport material across cells and cellular compartments separated by membranes. Protein assemblies are the cornerstone for the formation of channels and pores that enable this regulated passage of ...
Simon Finn Mayer, Chan Cao, Matteo Dal Peraro   +2 more
doaj   +3 more sources

Physical and chemical mechanisms of tissue optical clearing

iScience, 2021
Summary: Advanced optical methods combined with various probes pave the way toward molecular imaging within living cells. However, major challenges are associated with the need to enhance the imaging resolution even further to the subcellular level for ...
Tingting Yu, Jingtan Zhu, Dongyu Li, Dan Zhu   +3 more
doaj   +3 more sources

The Rigor and Transparency Index Quality Metric for Assessing Biological and Medical Science Methods

iScience, 2020
Summary: The reproducibility crisis is a multifaceted problem involving ingrained practices within the scientific community. Fortunately, some causes are addressed by the author's adherence to rigor and reproducibility criteria, implemented via ...
Joe Menke, Martijn Roelandse, Burak Ozyurt, Maryann Martone, Anita Bandrowski   +4 more
doaj   +3 more sources

Whole-brain optical access in a small adult vertebrate with two- and three-photon microscopy

iScience, 2022
Summary: Although optical microscopy has allowed scientists to study the entire brain in early developmental stages, access to the brains of live, adult vertebrates has been limited.
Najva Akbari, Rose L. Tatarsky, Kristine E. Kolkman, Joseph R. Fetcho, Andrew H. Bass, Chris Xu   +5 more
doaj   +1 more source

Redox-responsive polyurethane-polyurea nanoparticles targeting to aortic endothelium and atherosclerosis

iScience, 2022
Summary: Aortic endothelial cell dysfunction is an early trigger of atherosclerosis, the major cause of the cardiovascular disease (CVD). Nanomedicines targeting vascular endothelium and lesions hold great promise as therapeutic solutions to vascular ...
Yuxiang Zhou, David Hou, Cristina Cusco Marigo, Joaquín Bonelli, Pau Rocas, Fangzhou Cheng, Xiaoqiu Yang, Josep Rocas, Naomi M. Hamberg, Jingyan Han   +9 more
doaj   +1 more source

The RBPMSCreERT2-tdTomato mouse line for studying retinal and vascular relevant diseases

iScience, 2023
Summary: RNA-binding protein with multiple splicing (RBPMS) plays a crucial role in cardiac mesoderm specification and cardiovascular development, as well as being a typical marker for whole retinal ganglion cells (RGCs).
Guilan Li, Yuanting Luo, Qikai Zhang, Wenfei Chen, Kunbei Lai, Yizhi Liu, Yingfeng Zheng   +6 more
doaj   +1 more source

A method for investigating spatiotemporal growth patterns at cell and tissue levels during C-looping in the embryonic chick heart

iScience, 2022
Summary: We developed a workflow using multi-scale and multi-disciplinary experimental and computational approaches to analyze C-looping (the first phase of cardiac looping) of the chick across four developing hearts. We provide the first 3D datasets for
Nazanin Ebrahimi, Mahyar Osanlouy, Chris P. Bradley, M. Fabiana Kubke, Dane A. Gerneke, Peter J. Hunter   +5 more
doaj   +1 more source

Imaging mass cytometry reveals the prominent role of myeloid cells at the maternal-fetal interface

iScience, 2022
Summary: Although the immunological complexity of the maternal-fetal interface is well appreciated, the actual interaction of maternal immune cells and fetal trophoblasts is insufficiently understood. To comprehend the composition and spatial orientation
Juliette Krop, Anita van der Zwan, Marieke E. Ijsselsteijn, Hanneke Kapsenberg, Sietse J. Luk, Sanne H. Hendriks, Carin van der Keur, Lotte J. Verleng, Antonis Somarakis, Lotte van der Meeren, Geert Haasnoot, Manon Bos, Noel F.C.C. de Miranda, Susana M. Chuva de Sousa Lopes, Marie-Louise P. van der Hoorn, Frits Koning, Frans H.J. Claas, Sebastiaan Heidt, Michael Eikmans   +18 more
doaj   +1 more source

Sensitive image-based chromatin binding assays using inducible ERα to rapidly characterize estrogenic chemicals and mixtures

iScience, 2022
Summary: The United States Environmental Protection Agency (EPA) has been pursuing new high throughput in vitro assays to characterize endocrine disrupting chemicals (EDCs) that interact with estrogen receptor signaling.
Adam T. Szafran, Maureen G. Mancini, Fabio Stossi, Michael A. Mancini   +3 more
doaj   +1 more source