Results 11 to 20 of about 111,792 (265)

Imaging mass cytometry reveals the prominent role of myeloid cells at the maternal-fetal interface

iScience, 2022
Summary: Although the immunological complexity of the maternal-fetal interface is well appreciated, the actual interaction of maternal immune cells and fetal trophoblasts is insufficiently understood. To comprehend the composition and spatial orientation
Juliette Krop, Anita van der Zwan, Marieke E. Ijsselsteijn, Hanneke Kapsenberg, Sietse J. Luk, Sanne H. Hendriks, Carin van der Keur, Lotte J. Verleng, Antonis Somarakis, Lotte van der Meeren, Geert Haasnoot, Manon Bos, Noel F.C.C. de Miranda, Susana M. Chuva de Sousa Lopes, Marie-Louise P. van der Hoorn, Frits Koning, Frans H.J. Claas, Sebastiaan Heidt, Michael Eikmans   +18 more
doaj   +1 more source

A guide to pedagogical research for scientists from a biological sciences background [PDF]

, 2022
How we teach science and engage with the public, particularly in fast moving subjects such as microbiology, are constantly being reflected upon, improved and innovated.
Efthimiou, Georgios, Lacey, Melissa M.
core   +1 more source

Sensitive image-based chromatin binding assays using inducible ERα to rapidly characterize estrogenic chemicals and mixtures

iScience, 2022
Summary: The United States Environmental Protection Agency (EPA) has been pursuing new high throughput in vitro assays to characterize endocrine disrupting chemicals (EDCs) that interact with estrogen receptor signaling.
Adam T. Szafran, Maureen G. Mancini, Fabio Stossi, Michael A. Mancini   +3 more
doaj   +1 more source

Development of an in vivo system to model breast cancer metastatic organotropism and evaluate treatment response using the chick embryo

iScience, 2023
Summary: Metastatic lesions produced through the process of systemic tumor cell dissemination and growth at distant sites are challenging to treat and the primary cause of patient mortality.
Sumreen Javed, Sepideh Soukhtehzari, Nikki Salmond, Nazarine Fernandes, Karla C. Williams   +4 more
doaj   +1 more source

Influence of data sampling methods on the representation of neural spiking activity in vivo

iScience, 2022
Summary: In vivo single-unit recordings distinguish the basal spiking properties of neurons in different experimental settings and disease states. Here, we examined over 300 spike trains recorded from Purkinje cells and cerebellar nuclei neurons to test ...
Meike E. van der Heijden, Amanda M. Brown, Roy V. Sillitoe   +2 more
doaj   +1 more source

The ex vivo pharmacology of HIV-1 antiretrovirals differs between macaques and humans

iScience, 2022
Summary: Non-human primates (NHP) are widely used for the pre-clinical assessment of antiretrovirals (ARVs) for HIV treatment and prevention. However, the utility of these models is questionable given the differences in ARV pharmacology between humans ...
Carolina Herrera, Mackenzie L. Cottrell, John Prybylski, Angela D.M. Kashuba, Ronald S. Veazey, Javier García-Pérez, Natalia Olejniczak, Clare F. McCoy, Paul Ziprin, Nicola Richardson-Harman, José Alcami, Karl R. Malcolm, Robin J. Shattock   +12 more
doaj   +1 more source

Integrative processing of untargeted metabolomic and lipidomic data using MultiABLER

iScience, 2023
Summary: Mass spectrometry (MS)-based untargeted metabolomic and lipidomic approaches are being used increasingly in biomedical research. The adoption and integration of these data are critical to the overall multi-omic toolkit.
Ian C.H. Lee, Sergey Tumanov, Jason W.H. Wong, Roland Stocker, Joshua W.K. Ho   +4 more
doaj   +1 more source

Mapping-friendly sequence reductions: Going beyond homopolymer compression

iScience, 2022
Summary: Sequencing errors continue to pose algorithmic challenges to methods working with sequencing data. One of the simplest and most prevalent techniques for ameliorating the detrimental effects of homopolymer expansion/contraction errors present in ...
Luc Blassel, Paul Medvedev, Rayan Chikhi
doaj   +1 more source

Acoustic camera system for measuring ultrasound communication in mice

iScience, 2022
Summary: To investigate biological mechanisms underlying social behaviors and their deficits, social communication via ultrasonic vocalizations (USVs) in mice has received considerable attention as a powerful experimental model.
Jumpei Matsumoto, Kouta Kanno, Masahiro Kato, Hiroshi Nishimaru, Tsuyoshi Setogawa, Choijiljav Chinzorig, Tomohiro Shibata, Hisao Nishijo   +7 more
doaj   +1 more source

Biological and physiochemical methods of biofilm adhesion resistance control of medical-context surface [PDF]

, 2021
The formation of biofilms on medical-context surfaces gives the EPS embedded bacterial community protection and additional advantages that planktonic cells would not have such as increased antibiotic resistance and horizontal gene transfer.
Hao, Yu, Li, Yuanzhe, Li, Kexin, Li, Xiang, Liu, Yang, Dong, ZhiLi   +5 more
core   +1 more source