Results 1 to 10 of about 510,635 (307)

Saporin as a Commercial Reagent: Its Uses and Unexpected Impacts in the Biological Sciences—Tools from the Plant Kingdom [PDF]

Toxins, 2022
Saporin is a ribosome-inactivating protein that can cause inhibition of protein synthesis and causes cell death when delivered inside a cell. Development of commercial Saporin results in a technology termed ‘molecular surgery’, with Saporin as the ...
Leonardo R. Ancheta, Patrick A. Shramm, Raschel Bouajram, Denise Higgins, Douglas A. Lappi   +4 more
doaj   +5 more sources

The Biophysics of Lymphatic Transport: Engineering Tools and Immunological Consequences

iScience, 2019
Lymphatic vessels mediate fluid flows that affect antigen distribution and delivery, lymph node stromal remodeling, and cell-cell interactions, to thus regulate immune activation.
Meghan J. O'Melia, Amanda W. Lund, Susan N. Thomas   +2 more
doaj   +3 more sources

Aligning innovation and security in AI-enabled biotechnology: a framework for designing and funding mutually reinforcing approaches [PDF]

Frontiers in Microbiology
The convergence of artificial intelligence and biotechnology is transforming the life sciences and enabling rapid design, development, and analysis across the research lifecycle. However, this acceleration also heightens the risk for potential biological
Casey Aveggio, Sarah R. Carter, Harshini Mukundan, Elizabeth (Beth) E. Cameron, Steph Guerra   +4 more
doaj   +2 more sources

Data Management Plan for a Biotechnology and Biological Sciences Research Council (BBSRC) Tools and Resources Development Fund (TRDF) Grant [PDF]

Research Ideas and Outcomes, 2017
This Data Management Plan (DMP) was created for Laurent Gatto's BBSRC Tools and Resources Development Fund award (BB/N023129/1).  The DMP describes the management and sharing of all data and code associated with the grant, including software dissemination and release schedule, source code development and open source licensing, software ...
Laurent Gatto
doaj   +4 more sources

Redox-responsive polyurethane-polyurea nanoparticles targeting to aortic endothelium and atherosclerosis

iScience, 2022
Summary: Aortic endothelial cell dysfunction is an early trigger of atherosclerosis, the major cause of the cardiovascular disease (CVD). Nanomedicines targeting vascular endothelium and lesions hold great promise as therapeutic solutions to vascular ...
Yuxiang Zhou, David Hou, Cristina Cusco Marigo, Joaquín Bonelli, Pau Rocas, Fangzhou Cheng, Xiaoqiu Yang, Josep Rocas, Naomi M. Hamberg, Jingyan Han   +9 more
doaj   +1 more source

Identifying functional regulatory mutation blocks by integrating genome sequencing and transcriptome data

iScience, 2023
Summary: Millions of single nucleotide variants (SNVs) exist in the human genome; however, it remains challenging to identify functional SNVs associated with diseases.
Mingyi Yang, Omer Ali, Magnar Bjørås, Junbai Wang   +3 more
doaj   +1 more source

Integrative processing of untargeted metabolomic and lipidomic data using MultiABLER

iScience, 2023
Summary: Mass spectrometry (MS)-based untargeted metabolomic and lipidomic approaches are being used increasingly in biomedical research. The adoption and integration of these data are critical to the overall multi-omic toolkit.
Ian C.H. Lee, Sergey Tumanov, Jason W.H. Wong, Roland Stocker, Joshua W.K. Ho   +4 more
doaj   +1 more source

Physical and chemical mechanisms of tissue optical clearing

iScience, 2021
Summary: Advanced optical methods combined with various probes pave the way toward molecular imaging within living cells. However, major challenges are associated with the need to enhance the imaging resolution even further to the subcellular level for ...
Tingting Yu, Jingtan Zhu, Dongyu Li, Dan Zhu   +3 more
doaj   +1 more source

High-throughput submicron-resolution microscopy of Caenorhabditis elegans populations under strong immobilization by cooling cultivation plates

iScience, 2023
Summary: Despite its profound impact on biology, high-resolution in vivo microscopy largely remains low throughput because current immobilization techniques require substantial manual effort.
Yao L. Wang, Noa W.F. Grooms, Erik L. Jaklitsch, Leilani G. Schulting, Samuel H. Chung   +4 more
doaj   +1 more source

The role of antigen expression in shaping the repertoire of HLA presented ligands

iScience, 2022
Summary: Human leukocyte antigen (HLA) presentation of peptides is a prerequisite of T cell immune activation. The understanding of the rules defining this event has large implications for our knowledge of basic immunology and for the rational design of ...
Heli M. Garcia Alvarez, Zeynep Koşaloğlu-Yalçın, Bjoern Peters, Morten Nielsen   +3 more
doaj   +1 more source