Results 1 to 10 of about 507,580 (307)

A Linked Data Approach to Sharing Workflows and Workflow Results [PDF]

, 2010
A bioinformatics analysis pipeline is often highly elaborate, due to the inherent complexity of biological systems and the variety and size of datasets.
De Roure, David, Roos, M, Margaria, T, Bechhofer, Sean; id_orcid, David De Roure, Missier, P, Marshall, M. Scott, Marco Roos, Roos, Marco, Zhao, Jun, Newman, David, Marshall, MS, Newman, DR, Bechhofer, S, Sean Bechhofer, Zhao, J, Jun Zhao, Roure, DD, Newman, David R., David R. Newman, Paolo Missier, Steffen, B, Missier, Paolo, Bechhofer, Sean, M. Scott Marshall, Missier, Paolo; id_orcid   +25 more
core   +1 more source

A robust vessel-labeling pipeline with high tissue clearing compatibility for 3D mapping of vascular networks

iScience
Summary: The combination of vessel-labeling, tissue-clearing, and light-sheet imaging techniques provides a potent tool for accurately mapping vascular networks, enabling the assessment of vascular remodeling in vascular-related disorders.
Yating Deng, Jingtan Zhu, Xiaomei Liu, Junyao Dai, Tingting Yu, Dan Zhu   +5 more
doaj   +1 more source

Context-dependent 'safekeeping' of foraging tools in New Caledonian crows

, 2015
This work was supported by the Biotechnology and Biological Sciences Research Council (BBSRC; David Phillips Fellowship BB/G023913/2; C.R.), and studentships from the BBSRC (B.K.) and the University of St Andrews (J.v.d.W.).Several animal species use ...
James J. H. St Clair, Jessica E. M. van der Wal, van der Wal, Jessica Eva Megan, Klump, B., Christian Rutz, Rutz, Christian, St Clair, James, van der Wal, J., Klump, Barbara Christina, Barbara C. Klump, St Clair, J., Rutz, C.   +11 more
core   +1 more source

Developing ABEmax-NG with Precise Targeting and Expanded Editing Scope to Model Pathogenic Splice Site Mutations In Vivo

iScience, 2019
Summary: RNA splicing is related to many human diseases; however, lack of efficient genetic approaches to modulate splicing has prevented us from dissecting their functions in human diseases.
Shisheng Huang, Zhaodi Liao, Xiangyang Li, Zhen Liu, Guanglei Li, Jianan Li, Zongyang Lu, Yu Zhang, Xiajun Li, Xu Ma, Qiang Sun, Xingxu Huang   +11 more
doaj   +1 more source

Computational Tools for Discovering and Engineering Natural Product Biosynthetic Pathways

iScience, 2020
Natural products (NPs), also known as secondary metabolites, are produced in bacteria, fungi, and plants. NPs represent a rich source of antibacterial, antifungal, and anticancer agents.
Hengqian Ren, Chengyou Shi, Huimin Zhao
doaj   +1 more source

New Caledonian crows attend to multiple functional properties of complex tools

, 2013
The ability to attend to the functional properties of foraging tools should affect energy-intake rates, fitness components and ultimately the evolutionary dynamics of tool-related behaviour.
St Clair, James J H, Rutz, Christian
core   +1 more source

Bioinformatics for Researchers in Life Sciences: Tools and Learning Resources

, 2022
The COVID-19 pandemic has shown that bioinformatics--a multidisciplinary field that combines biological knowledge with computer programming concerned with the acquisition, storage, analysis, and dissemination of biological data--has a fundamental role in
Inter-American Development Bank
core   +1 more source

Interlaboratory consistency of SDC2 promoter methylation detection in colorectal cancer using the post-optimized materials

iScience
Summary: Fecal DNA-based Syndecan 2 (SDC2) methylation detection is a promising non-invasive strategy for early colorectal cancer (CRC) screening. In China, commercial assays for SDC2 methylation detection vary in sensitivity and specificity, yet there ...
Lijing Zhang, Duo Wang, Ziqiang Li, Guigao Lin, Jinming Li, Rui Zhang   +5 more
doaj   +1 more source

Label-free 3D-CLEM Using Endogenous Tissue Landmarks

iScience, 2018
Summary: Emerging 3D correlative light and electron microscopy approaches enable studying neuronal structure-function relations at unprecedented depth and precision.
Manja Luckner, Steffen Burgold, Severin Filser, Maximilian Scheungrab, Yilmaz Niyaz, Eric Hummel, Gerhard Wanner, Jochen Herms   +7 more
doaj   +1 more source

Strong between-site variation in New Caledonian crows' use of hook-tool-making materials

, 2016
The study was funded through a BBSRC David Phillips Fellowship (grants BB/G023913/1 and BB/G023913/2 to CR) and doctoral studentships from the BBSRC (BK), JASSO (SS), and the School of Biology, University of St Andrews (JvdW).Functional tool use requires
van der Wal, Jessica Eva Megan, Klump, B., Rutz, Christian, St Clair, James, van der Wal, J., Sugasawa, S., Klump, Barbara Christina, St Clair, J., Sugasawa, Shoko, Rutz, C.   +9 more
core   +1 more source