Results 41 to 50 of about 1,333,897 (299)

Why Biology is Beyond Physical Sciences? [PDF]

, 2016
In the framework of materialism, the major attention is to find general organizational laws stimulated by physical sciences, ignoring the uniqueness of Life.
Muni, Bhakti Vijnana, Shanta, Bhakti Niskama   +1 more
core   +1 more source

A robust vessel-labeling pipeline with high tissue clearing compatibility for 3D mapping of vascular networks

iScience
Summary: The combination of vessel-labeling, tissue-clearing, and light-sheet imaging techniques provides a potent tool for accurately mapping vascular networks, enabling the assessment of vascular remodeling in vascular-related disorders.
Yating Deng, Jingtan Zhu, Xiaomei Liu, Junyao Dai, Tingting Yu, Dan Zhu   +5 more
doaj   +1 more source

Developing ABEmax-NG with Precise Targeting and Expanded Editing Scope to Model Pathogenic Splice Site Mutations In Vivo

iScience, 2019
Summary: RNA splicing is related to many human diseases; however, lack of efficient genetic approaches to modulate splicing has prevented us from dissecting their functions in human diseases.
Shisheng Huang, Zhaodi Liao, Xiangyang Li, Zhen Liu, Guanglei Li, Jianan Li, Zongyang Lu, Yu Zhang, Xiajun Li, Xu Ma, Qiang Sun, Xingxu Huang   +11 more
doaj   +1 more source

Computational Tools for Discovering and Engineering Natural Product Biosynthetic Pathways

iScience, 2020
Natural products (NPs), also known as secondary metabolites, are produced in bacteria, fungi, and plants. NPs represent a rich source of antibacterial, antifungal, and anticancer agents.
Hengqian Ren, Chengyou Shi, Huimin Zhao
doaj   +1 more source

An Applied Empirical Framework for Invasion Science: Confronting Biological Invasion Through Collaborative Research Aimed at Tool Production

Annals of the Entomological Society of America, 2020
AbstractGlobal ecosystem functions, services, and commodities are increasingly threatened by biological invasions. As a result, there is an urgent need to manage invasive species through global collaborative research. We propose an ‘applied empirical framework’ (AEF) to aggressively confront the current global biological invasion crisis. The AEF builds
Gwylim S Blackburn, Pierre Bilodeau, Tracey Cooke, Mingming Cui, Michel Cusson, Richard C Hamelin, Melody A Keena, Sandrine Picq, Amanda D Roe, Juan Shi, Yunke Wu, Ilga Porth   +11 more
openaire   +1 more source

Interlaboratory consistency of SDC2 promoter methylation detection in colorectal cancer using the post-optimized materials

iScience
Summary: Fecal DNA-based Syndecan 2 (SDC2) methylation detection is a promising non-invasive strategy for early colorectal cancer (CRC) screening. In China, commercial assays for SDC2 methylation detection vary in sensitivity and specificity, yet there ...
Lijing Zhang, Duo Wang, Ziqiang Li, Guigao Lin, Jinming Li, Rui Zhang   +5 more
doaj   +1 more source

Label-free 3D-CLEM Using Endogenous Tissue Landmarks

iScience, 2018
Summary: Emerging 3D correlative light and electron microscopy approaches enable studying neuronal structure-function relations at unprecedented depth and precision.
Manja Luckner, Steffen Burgold, Severin Filser, Maximilian Scheungrab, Yilmaz Niyaz, Eric Hummel, Gerhard Wanner, Jochen Herms   +7 more
doaj   +1 more source

Single-molecule fluorescence microscopy review : shedding new light on old problems [PDF]

, 2017
Fluorescence microscopy is an invaluable tool in the biosciences, a genuine workhorse technique offering exceptional contrast in conjunction with high specificity of labelling with relatively minimal perturbation to biological samples compared with many ...
Leake, Mark Christian, Shashkova, Sviatlana   +1 more
core   +1 more source

All-Optical Volumetric Physiology for Connectomics in Dense Neuronal Structures

iScience, 2019
Summary: All-optical physiology (AOP) manipulates and reports neuronal activities with light, allowing for interrogation of neuronal functional connections with high spatiotemporal resolution. However, contemporary high-speed AOP platforms are limited to
Chiao Huang, Chu-Yi Tai, Kai-Ping Yang, Wei-Kun Chang, Kuo-Jen Hsu, Ching-Chun Hsiao, Shun-Chi Wu, Yen-Yin Lin, Ann-Shyn Chiang, Shi-Wei Chu   +9 more
doaj   +1 more source

Citizen Science as a Tool to Get Baseline Ecological and Biological Data on Sharks and Rays in a Data-Poor Region

Sustainability, 2022
The Mexican Caribbean is in one of the regions with the greatest diversity of elasmobranchs in the world. However, the population status of most of the shark and ray species in this region is unknown. We used a citizen science program based on divers to collect data about the diversity, abundance, and distribution of elasmobranchs in this region.
María-del-Pilar Blanco-Parra, Angelli Argaez Gasca, Camila Alejandra Reyes Rincón, Nicte Ha Gutiérrez Martínez, Carlos Alberto Niño-Torres   +4 more
openaire   +1 more source