Results 21 to 30 of about 507,580 (307)
iScience, 2023 Summary: Despite its profound impact on biology, high-resolution in vivo microscopy largely remains low throughput because current immobilization techniques require substantial manual effort.
Yao L. Wang +4 more
doaj +1 more source
The role of antigen expression in shaping the repertoire of HLA presented ligands
iScience, 2022 Summary: Human leukocyte antigen (HLA) presentation of peptides is a prerequisite of T cell immune activation. The understanding of the rules defining this event has large implications for our knowledge of basic immunology and for the rational design of ...
Heli M. Garcia Alvarez +3 more
doaj +1 more source
iScience, 2022 Summary: Early detection of pathogenic bacteria is needed for rapid diagnostics allowing adequate and timely treatment of infections. In this study, we show that secondary electrospray ionization–high resolution mass spectrometry (SESI-HRMS) can be used ...
Alejandro Gómez-Mejia +7 more
doaj +1 more source
iScience, 2021 Summary: The mechanical properties of the extracellular matrix strongly influence tumor progression and invasion. Yes-associated protein (YAP) has been shown to be a key regulator of this process translating mechanical cues from the extracellular matrix ...
Bernhard Illes +6 more
doaj +1 more source
Polyvalent guide RNAs for CRISPR antivirals
iScience, 2022 Summary: CRISPR effector Cas13 recognizes and degrades RNA molecules that are complementary to its guide RNA (gRNA) and possesses potential as an antiviral biotechnology because it can degrade viral mRNA and RNA genomes.
Rammyani Bagchi +6 more
doaj +1 more source
iScience, 2023 Summary: Functional explication of genes is of great scientific value. However, conventional methods have challenges for those genes that may affect biological processes but are not annotated in public databases.
Ying Wang +13 more
doaj +1 more source
Development of small fluorescent probes for the analysis of autophagy kinetics
iScience, 2023 Summary: Autophagy is a dynamic process that degrades subcellular constituents, and its activity is measured by autophagic flux. The tandem proteins RFP-GFP-LC3 and GFP-LC3-RFP-LC3ΔG, which enable the visualization of autophagic vacuoles of different ...
Hajime Tajima Sakurai +9 more
doaj +1 more source
Automated design of gene circuits with optimal mushroom-bifurcation behavior
iScience, 2023 Summary: Recent advances in synthetic biology are enabling exciting technologies, including the next generation of biosensors, the rational design of cell memory, modulated synthetic cell differentiation, and generic multifunctional biocircuits.
Irene Otero-Muras +3 more
doaj +1 more source
Data Management Plan for a Biotechnology and Biological Sciences Research Council (BBSRC) Tools and Resources Development Fund (TRDF) Grant [PDF]
Research Ideas and Outcomes, 2017 This Data Management Plan (DMP) was created for Laurent Gatto's BBSRC Tools and Resources Development Fund award (BB/N023129/1). The DMP describes the management and sharing of all data and code associated with the grant, including software dissemination and release schedule, source code development and open source licensing, software ...
Laurent Gatto
doaj +4 more sources
Mass spectrometry-based proteomics as a tool to identify biological matrices in forensic science [PDF]
International Journal of Legal Medicine, 2012 In forensic casework analysis, identification of the biological matrix and the species of a forensic trace, preferably without loss of DNA, is of major importance. The biological matrices that can be encountered in a forensic context are blood (human or non-human), saliva, semen, vaginal fluid, and to a lesser extent nasal secretions, feces, and urine.
Van Steendam, Katleen +4 more
openaire +3 more sources