Results 11 to 20 of about 16,651,738 (349)
iScience, 2023 Summary: Millions of single nucleotide variants (SNVs) exist in the human genome; however, it remains challenging to identify functional SNVs associated with diseases.
Mingyi Yang +3 more
doaj +1 more source
Integrative processing of untargeted metabolomic and lipidomic data using MultiABLER
iScience, 2023 Summary: Mass spectrometry (MS)-based untargeted metabolomic and lipidomic approaches are being used increasingly in biomedical research. The adoption and integration of these data are critical to the overall multi-omic toolkit.
Ian C.H. Lee +4 more
doaj +1 more source
Physical and chemical mechanisms of tissue optical clearing
iScience, 2021 Summary: Advanced optical methods combined with various probes pave the way toward molecular imaging within living cells. However, major challenges are associated with the need to enhance the imaging resolution even further to the subcellular level for ...
Tingting Yu +3 more
doaj +1 more source
iScience, 2023 Summary: Despite its profound impact on biology, high-resolution in vivo microscopy largely remains low throughput because current immobilization techniques require substantial manual effort.
Yao L. Wang +4 more
doaj +1 more source
An open source knowledge graph ecosystem for the life sciences [PDF]
Scientific Data, 2023 Translational research requires data at multiple scales of biological organization. Advancements in sequencing and multi-omics technologies have increased the availability of these data, but researchers face significant integration challenges.
T. Callahan +31 more
semanticscholar +1 more source
The role of antigen expression in shaping the repertoire of HLA presented ligands
iScience, 2022 Summary: Human leukocyte antigen (HLA) presentation of peptides is a prerequisite of T cell immune activation. The understanding of the rules defining this event has large implications for our knowledge of basic immunology and for the rational design of ...
Heli M. Garcia Alvarez +3 more
doaj +1 more source
iScience, 2022 Summary: Early detection of pathogenic bacteria is needed for rapid diagnostics allowing adequate and timely treatment of infections. In this study, we show that secondary electrospray ionization–high resolution mass spectrometry (SESI-HRMS) can be used ...
Alejandro Gómez-Mejia +7 more
doaj +1 more source
iScience, 2021 Summary: The mechanical properties of the extracellular matrix strongly influence tumor progression and invasion. Yes-associated protein (YAP) has been shown to be a key regulator of this process translating mechanical cues from the extracellular matrix ...
Bernhard Illes +6 more
doaj +1 more source
Polyvalent guide RNAs for CRISPR antivirals
iScience, 2022 Summary: CRISPR effector Cas13 recognizes and degrades RNA molecules that are complementary to its guide RNA (gRNA) and possesses potential as an antiviral biotechnology because it can degrade viral mRNA and RNA genomes.
Rammyani Bagchi +6 more
doaj +1 more source
iScience, 2023 Summary: Functional explication of genes is of great scientific value. However, conventional methods have challenges for those genes that may affect biological processes but are not annotated in public databases.
Ying Wang +13 more
doaj +1 more source