Results 51 to 60 of about 1,333,897 (299)
Pediatric Blood &Cancer, EarlyView.ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski +9 more
wiley +1 more source
MALVA: Genotyping by Mapping-free ALlele Detection of Known VAriants
iScience, 2019 Summary: The amount of genetic variation discovered in human populations is growing rapidly leading to challenging computational tasks, such as variant calling.
Luca Denti +4 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Introduction Pulmonary dysfunction and sleep abnormalities are common in children with sickle cell disease (SCD) and are associated with worse clinical outcomes. Whether spirometry abnormalities are associated with polysomnography (PSG) findings remains unclear.
Ammar Saadoon Alishlash +4 more
wiley +1 more source
Visualizing Ligand Binding to a GPCR In Vivo Using NanoBRET
iScience, 2018 Summary: The therapeutic action of a drug depends on its ability to engage with its molecular target in vivo. However, current drug discovery strategies quantify drug levels within organs rather than determining the binding of drugs directly to their ...
Diana C. Alcobia +9 more
doaj +1 more source
Computational and Structural Biotechnology Journal, 2022 LC–MS/MS is a major analytical platform for metabolomics, which has become a recent hotspot in the research fields of life and environmental sciences. By contrast, structure elucidation of small molecules based on LC–MS/MS data remains a major challenge ...
Zhitao Tian +4 more
doaj +1 more source
Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM
FEBS Letters, EarlyView.Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley +1 more source
A First Exposure to Statistical Mechanics for Life Scientists [PDF]
, 2007 Statistical mechanics is one of the most powerful and elegant tools in the quantitative sciences. One key virtue of statistical mechanics is that it is designed to examine large systems with many interacting degrees of freedom, providing a clue that it ...
Garcia, Hernan G. +4 more
core
Wild clocks: preface and glossary [PDF]
, 2017 No abstract ...
Gerkema, Menno P. +2 more
core +3 more sources
Architectural Principles for Characterizing the Performance of Antithetic Integral Feedback Networks
iScience, 2019 Summary: As we begin to design increasingly complex synthetic biomolecular systems, it is essential to develop rational design methodologies that yield predictable circuit performance.
Noah Olsman +2 more
doaj +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source