Results 51 to 60 of about 510,635 (307)

A robust vessel-labeling pipeline with high tissue clearing compatibility for 3D mapping of vascular networks

iScience
Summary: The combination of vessel-labeling, tissue-clearing, and light-sheet imaging techniques provides a potent tool for accurately mapping vascular networks, enabling the assessment of vascular remodeling in vascular-related disorders.
Yating Deng, Jingtan Zhu, Xiaomei Liu, Junyao Dai, Tingting Yu, Dan Zhu   +5 more
doaj   +1 more source

Benchmarking selected computational gene network growing tools in context of virus-host interactions [PDF]

, 2017
Several available online tools provide network growing functions where an algorithm utilizing different data sources suggests additional genes/proteins that should connect an input gene set into functionally meaningful networks.
Maurer-Stroh, S, Candida Vaz, Kuznetsov, Vladimir A., Vaz, Candida, Eisenhaber, Frank, Sugrue, Richard J., Sugrue, R.J, Richard J. Sugrue, Vaz, C, Kuznetsov, V.A, Tanavde, Vivek, Vivek Tanavde, Eisenhaber, F, Frank Eisenhaber, Biruhalem Taye, Taye, Biruhalem, Sebastian Maurer-Stroh, Tanavde, V, Taye, B, Maurer-Stroh, Sebastian, Vladimir A. Kuznetsov   +20 more
core   +1 more source

Developing ABEmax-NG with Precise Targeting and Expanded Editing Scope to Model Pathogenic Splice Site Mutations In Vivo

iScience, 2019
Summary: RNA splicing is related to many human diseases; however, lack of efficient genetic approaches to modulate splicing has prevented us from dissecting their functions in human diseases.
Shisheng Huang, Zhaodi Liao, Xiangyang Li, Zhen Liu, Guanglei Li, Jianan Li, Zongyang Lu, Yu Zhang, Xiajun Li, Xu Ma, Qiang Sun, Xingxu Huang   +11 more
doaj   +1 more source

Interlaboratory consistency of SDC2 promoter methylation detection in colorectal cancer using the post-optimized materials

iScience
Summary: Fecal DNA-based Syndecan 2 (SDC2) methylation detection is a promising non-invasive strategy for early colorectal cancer (CRC) screening. In China, commercial assays for SDC2 methylation detection vary in sensitivity and specificity, yet there ...
Lijing Zhang, Duo Wang, Ziqiang Li, Guigao Lin, Jinming Li, Rui Zhang   +5 more
doaj   +1 more source

Label-free 3D-CLEM Using Endogenous Tissue Landmarks

iScience, 2018
Summary: Emerging 3D correlative light and electron microscopy approaches enable studying neuronal structure-function relations at unprecedented depth and precision.
Manja Luckner, Steffen Burgold, Severin Filser, Maximilian Scheungrab, Yilmaz Niyaz, Eric Hummel, Gerhard Wanner, Jochen Herms   +7 more
doaj   +1 more source

Computational Tools for Discovering and Engineering Natural Product Biosynthetic Pathways

iScience, 2020
Natural products (NPs), also known as secondary metabolites, are produced in bacteria, fungi, and plants. NPs represent a rich source of antibacterial, antifungal, and anticancer agents.
Hengqian Ren, Chengyou Shi, Huimin Zhao
doaj   +1 more source

All-Optical Volumetric Physiology for Connectomics in Dense Neuronal Structures

iScience, 2019
Summary: All-optical physiology (AOP) manipulates and reports neuronal activities with light, allowing for interrogation of neuronal functional connections with high spatiotemporal resolution. However, contemporary high-speed AOP platforms are limited to
Chiao Huang, Chu-Yi Tai, Kai-Ping Yang, Wei-Kun Chang, Kuo-Jen Hsu, Ching-Chun Hsiao, Shun-Chi Wu, Yen-Yin Lin, Ann-Shyn Chiang, Shi-Wei Chu   +9 more
doaj   +1 more source

Strategies for structure elucidation of small molecules based on LC–MS/MS data from complex biological samples

Computational and Structural Biotechnology Journal, 2022
LC–MS/MS is a major analytical platform for metabolomics, which has become a recent hotspot in the research fields of life and environmental sciences. By contrast, structure elucidation of small molecules based on LC–MS/MS data remains a major challenge ...
Zhitao Tian, Fangzhou Liu, Dongqin Li, Alisdair R. Fernie, Wei Chen   +4 more
doaj   +1 more source

The Use of Internet-Based Social Media as a Tool in Enhancing Student’s Learning Experiences in Biological Sciences

Higher Learning Research Communications, 2013
<p>This study explored the use of social media as a tool in enhancing student’s learning experiences, by using online instruction as a supplement to a face-to-face general education course, such as biological sciences. Survey data were collected from 186 students who were enrolled in a Biological Sciences course.
Beltran Cruz, Maribel, B. Cruz, Shannen Belle   +1 more
openaire   +5 more sources

Colib’read on galaxy: a tools suite dedicated to biological information extraction from raw NGS reads [PDF]

, 2016
International audienceBackground: With next-generation sequencing (NGS) technologies, the life sciences face a deluge of raw data.Classical analysis processes for such data often begin with an assembly step, needing large amounts of computingresources ...
Rivals, Eric, Marchet, Camille, Camille Marchet, Vincent Miele, Pierre Peterlongo, Collin, Olivier, Claire Lemaitre, Raluca Uricaru, Salmela, Leena, Alexan Andrieux, Bastien Cazaux, Sacomoto, Gustavo, Le Bras, Yvan, Cyril Monjeaud, Leena Salmela, Miele, Vincent, Monjeaud, Cyril, Cazaux, Bastien, Andrieux, Alexan, Olivier Collin, El Aabidine, Amal Zine, Lacroix, Vincent, Alves Carvalho, Susete, Yvan Le Bras, Susete Alves-Carvalho, Uricaru, Raluca, Gustavo Sacomoto, Lemaitre, Claire, Éric Rivals, Vincent Lacroix, Peterlongo, Pierre, Amal Zine El Aabidine, Alves-Carvalho, Susete   +32 more
core   +1 more source