Results 51 to 60 of about 16,651,738 (349)

Algorithms and tools for data-driven omics integration to achieve multilayer biological insights: a narrative review

Journal of Translational Medicine
Systems biology is a holistic approach to biological sciences that combines experimental and computational strategies, aimed at integrating information from different scales of biological processes to unravel pathophysiological mechanisms and behaviours.
A. Morabito, Giulia De Simone, R. Pastorelli, L. Brunelli, Manuela Ferrario   +4 more
semanticscholar   +1 more source

The Biophysics of Lymphatic Transport: Engineering Tools and Immunological Consequences

iScience, 2019
Lymphatic vessels mediate fluid flows that affect antigen distribution and delivery, lymph node stromal remodeling, and cell-cell interactions, to thus regulate immune activation.
Meghan J. O'Melia, Amanda W. Lund, Susan N. Thomas   +2 more
doaj   +1 more source

Soil salinity: A serious environmental issue and plant growth promoting bacteria as one of the tools for its alleviation

Saudi Journal of Biological Sciences, 2014
Salinity is one of the most brutal environmental factors limiting the productivity of crop plants because most of the crop plants are sensitive to salinity caused by high concentrations of salts in the soil, and the area of land affected by it is ...
P. Shrivastava, Rajesh Kumar
semanticscholar   +1 more source

All-Optical Volumetric Physiology for Connectomics in Dense Neuronal Structures

iScience, 2019
Summary: All-optical physiology (AOP) manipulates and reports neuronal activities with light, allowing for interrogation of neuronal functional connections with high spatiotemporal resolution. However, contemporary high-speed AOP platforms are limited to
Chiao Huang, Chu-Yi Tai, Kai-Ping Yang, Wei-Kun Chang, Kuo-Jen Hsu, Ching-Chun Hsiao, Shun-Chi Wu, Yen-Yin Lin, Ann-Shyn Chiang, Shi-Wei Chu   +9 more
doaj   +1 more source

The Use of Internet-Based Social Media as a Tool in Enhancing Student’s Learning Experiences in Biological Sciences

Higher Learning Research Communications, 2013
<p>This study explored the use of social media as a tool in enhancing student’s learning experiences, by using online instruction as a supplement to a face-to-face general education course, such as biological sciences. Survey data were collected from 186 students who were enrolled in a Biological Sciences course.
Beltran Cruz, Maribel, B. Cruz, Shannen Belle   +1 more
openaire   +5 more sources

Early Body Mass Index z‐Score Change and Resolution of Severe Malnutrition in Children With Sickle Cell Anemia in a Low‐Income Setting: A Prospective Single‐Arm Extension Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Children with sickle cell anemia (SCA) in low‐income settings are at risk of severe malnutrition, but optimal nutritional management has not been established. We evaluated an intensified ready‐to‐use therapeutic food (RUTF) regimen in children with persistent severe malnutrition after initial treatment and assessed whether early ...
Safiya Gambo, Shehu Umar Abdullahi, Hassan Adam Murtala, Halima Kabir, Khadija A. Shamsu, Sari A. Acra, Virginia A. Stallings, Mark Rodeghier, Michael R. DeBaun, Lauren J. Klein   +9 more
wiley   +1 more source

MALVA: Genotyping by Mapping-free ALlele Detection of Known VAriants

iScience, 2019
Summary: The amount of genetic variation discovered in human populations is growing rapidly leading to challenging computational tasks, such as variant calling.
Luca Denti, Marco Previtali, Giulia Bernardini, Alexander Schönhuth, Paola Bonizzoni   +4 more
doaj   +1 more source

Comparative Drug Response Profiling in Neuroblastoma Cell Lines and Patient‐Derived Tumor Organoids

Pediatric Blood &Cancer, EarlyView.
ABSTRACT High‐risk neuroblastoma remains a leading cause of pediatric cancer mortality, and improved preclinical models are needed to guide therapeutic developments. We screened seven high‐risk neuroblastoma cell lines and three patient‐derived tumor organoids with 528 compounds alongside bone marrow controls, and compared them with external datasets ...
Krzysztof Wierbiłowicz, Se Whee Sammy Park, Aironas Los, Ernest Liu, Nona Struyf, Tom Erkers, Sören Lehmann, Jan J. Molenaar, Jakob Stenman, Olli Kallioniemi, Päivi Östling, Brinton Seashore‐Ludlow, Kasper Karlsson   +12 more
wiley   +1 more source

Visualizing Ligand Binding to a GPCR In Vivo Using NanoBRET

iScience, 2018
Summary: The therapeutic action of a drug depends on its ability to engage with its molecular target in vivo. However, current drug discovery strategies quantify drug levels within organs rather than determining the binding of drugs directly to their ...
Diana C. Alcobia, Alexandra I. Ziegler, Alexander Kondrashov, Eleonora Comeo, Sarah Mistry, Barrie Kellam, Aeson Chang, Jeanette Woolard, Stephen J. Hill, Erica K. Sloan   +9 more
doaj   +1 more source

Venetoclax‐Based Therapy as a Bridge to Hematopoietic Stem Cell Transplantation in Relapsed or Refractory Pediatric Acute Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Relapsed and/or refractory (R/R) pediatric acute leukemia carries a dismal prognosis, largely driven by chemoresistance to conventional salvage therapy. The BH3‐mimetic venetoclax, combined with chemotherapy or hypomethylating agents, has demonstrated efficacy in small clinical trials.
Katherine S. Colman, Deborah Meyran, Vajiranee Malalasekera, Heather Weerdenburg, Janine Campbell, Rachel Conyers, Stacie Wang, Hannah Walker, Seong Lin Khaw, Diane Hanna   +9 more
wiley   +1 more source