In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara +3 more
wiley +1 more source
Another 10 years of PLOS Computational Biology: A data-driven reflection on trends in genomics research. [PDF]
Fan J.
europepmc +1 more source
Home-Based Sci-Lab Experiments in Developing Scientific Skills in General Biology 2
Jerlene Limon-Dacalos Jerlene Limon-Dacalos
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Directed evolution of enzymes at the crossroads of tradition and innovation
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Correction: Effects of extensive protein hydrolysate in supporting intestinal barrier function in vitro. [PDF]
Bozzetti V +9 more
europepmc +1 more source
Impact of BioWeb on Grade 12 STEM students’ academic performance in General Biology 2
Carla May Tidor
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TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose +9 more
wiley +1 more source
Corrigendum: Błaszkowski J, Goto BT, Zubek S, Milczarski P, Malinowski R, Niezgoda P, Błaszkowski T (2025) <i>Paracorymbiglomus</i> gen. nov., <i>Diversispora conica</i> sp. nov., and new combinations in Diversisporaceae (Glomeromycota). MycoKeys 117: 171-190. https://doi.org/10.3897/mycokeys.117.148052. [PDF]
Błaszkowski J +6 more
europepmc +1 more source
Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro +1 more
wiley +1 more source
The Role of Theory in Biology: How You Can Be, and Likely Already Are, a Theoretician. [PDF]
Scheiner SM.
europepmc +1 more source

