Results 41 to 50 of about 2,135,197 (304)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Heterogeneity of macrophage infiltration and therapeutic response in lung carcinoma revealed by 3D organ imaging

Nature Communications, 2017
Tumour-associated macrophages (TAM) can be used as prognostic indicators in cancer. Here, the authors establish a platform for high-throughput 3D microscopy in murine lung carcinoma that allows to visualize TAMs infiltration throughout the entire lung ...
Michael F. Cuccarese, J. Matthew Dubach, Christina Pfirschke, Camilla Engblom, Christopher Garris, Miles A. Miller, Mikael J. Pittet, Ralph Weissleder   +7 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Nano-palladium is a cellular catalyst for in vivo chemistry

Nature Communications, 2017
Palladium (Pd) is a well-known catalyst in organic chemistry but its use in nanomedicine is limited. Here, the authors design a Pd nanoparticle that triggers the activation of an antitumour prodrugin vivo, which shows efficacy and improves toxicity ...
Miles A. Miller, Bjorn Askevold, Hannes Mikula, Rainer H. Kohler, David Pirovich, Ralph Weissleder   +5 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Integrative Systems Biology Visualization with MAYDAY

Journal of Integrative Bioinformatics, 2010
Visualization is pivotal for gaining insight in systems biology data. As the size and complexity of datasets and supplemental information increases, an efficient, integrated framework for general and specialized views is necessary.
Symonsy Stephan, Zipplies Christian, Battke Florian, Nieselt Kay   +3 more
doaj   +1 more source

Darwin in mind : new opportunities for evolutionary psychology

, 2011
Evolutionary Psychology (EP) views the human mind as organized into many modules, each underpinned by psychological adaptations designed to solve problems faced by our Pleistocene ancestors.
Bolhuis Johan J., Laland, Kevin Neville, Gillian R. Brown, Kevin N Laland, Brown Gillian R., Johan J. Bolhuis, Brown, Gillian Ruth, Kevin N. Laland, Bolhuis, Johan, Gillian R Brown, Laland Kevin N., Robert C Richardson, Richardson, Robert, Richardson Robert C., Robert C. Richardson, Johan J Bolhuis   +15 more
core   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

THE EFFECTIVENESS OF THE APPLICATION OF THE METHODOLOGY OF PROJECT-BASED LEARNING IN GENERAL BIOLOGY IN THE FORMATION OF STUDENTS' SUBJECT AND META-SUBJECT COMPETENCIES

Russian Journal of Education and Psychology
Background. The system-activity approach as the methodological basis of modern educational standards has determined the need to involve schoolchildren in project activities at all levels of general education in accordance with the principle of continuity
Andzhelika M. Shekhmirzova, Lyudmila V. Gribina, Fatima A. Tuguz, Nafiset S. Blagoz   +3 more
doaj   +1 more source