Results 1 to 10 of about 30,915 (147)

Vitamin D Supplementation and Mortality in the Elderly: A Review of a Meta-Analysis of Randomized Controlled Trials Using the REB Method. [PDF]

Fundam Clin Pharmacol
ABSTRACT Background The results of randomized controlled trials (RCTs) regarding the effect of vitamin D supplementation on mortality reduction are conflicting. Objective The aim of this study was to assess the level of evidence through a sensitivity analysis of the meta‐analysis by Shah et al.
Kostakis N, Lega JC, Boussageon R.
europepmc   +2 more sources

Redefining Regulatory Proof: The End of the Two-Trial Paradigm. [PDF]

Fundam Clin Pharmacol
ABSTRACT The recent decision to establish a single pivotal trial as the default evidentiary standard for Food and Drug Administration (FDA) approval marks a substantive shift in the architecture of regulatory proof. This marks a shift from replication‐based validation to a coherence‐based model of sufficiency, beyond a procedural adjustment.
Lega JC, Provencher S, Falissard B, Locher C, Roustit M, Gougeon A, Boussageon R, Chevret S.   +7 more
europepmc   +2 more sources

From Inference to Ritual: Why Frequentist Statistics Became Hard to Understand and Teach in Medicine. [PDF]

J Eval Clin Pract
ABSTRACT Introduction Frequentist statistical tools still structure a large part of biomedical research, regulatory evaluation, and medical teaching, even though their correct interpretation remains uncertain among students, clinicians, and readers of the literature.
Lega JC, Chevret S.
europepmc   +2 more sources

Validating the 2022 WHO classification in thyroid carcinomas: Prospective evidence for predicting iodine resistance. [PDF]

Histopathology
This study assessed the 2022 WHO classification for predicting RAIR disease in thyroid carcinomas, comparing it to older classifications. In a retrospective study of 253 cases, we found the 2022 classification more effective, especially by identifying high‐grade carcinomas and tumour necrosis as critical predictive factors.
André E, Mebarki L, Ilie M, Subtil F, Bournaud C, Borson-Chazot F, Descotes F, Lifante JC, Bertholon-Grégoire M, Lasolle H, Decaussin-Petrucci M.   +10 more
europepmc   +2 more sources

Pre- Versus Post-Breeding Population Projection Models? A Simple Fix to a Common Parametrization Error. [PDF]

Ecol Evol
Population Projection Models (PPMs) are essential tools in demographic studies for predicting the growth of structured populations. This work introduces a simple, robust method for constructing pre‐ and post‐breeding projection matrices called MAP for Matrices Alternated Products directly from empirical data, addressing common errors related to ...
Martin TLP, Gaillard JM, Bonenfant C.
europepmc   +2 more sources

Health Vigilance for Medical Imaging Diagnostic Optimization: Automated segmentation of COVID-19 lung infection from CT images [PDF]

E3S Web of Conferences, 2021
Covid-19 disease has confronted the world with an unprecedented health crisis, faced with its quick spread, the health system is called upon to increase its vigilance.
Mohamed Chala, Nsiri Benayad, Abdelmajid Soulaymani, Abdelghani Mokhtari, Brahim Benaji   +4 more
doaj   +1 more source

Experimental evolution of virulence and associated traits in a Drosophila melanogaster–Wolbachia symbiosis

Peer Community Journal, 2021
Evolutionary theory predicts that vertically transmitted symbionts are selected for low virulence, as their fitness is directly correlated to that of their host.
Monnin, David, Kremer, Natacha, Michaud, Caroline, Villa, Manon, Henri, Hélène, Desouhant, Emmanuel, Vavre, Fabrice   +6 more
doaj   +1 more source

Efficiently sparse listing of classes of optimal cophylogeny reconciliations

Algorithms for Molecular Biology, 2022
Background Cophylogeny reconciliation is a powerful method for analyzing host-parasite (or host-symbiont) co-evolution. It models co-evolution as an optimization problem where the set of all optimal solutions may represent different biological scenarios ...
Yishu Wang, Arnaud Mary, Marie-France Sagot, Blerina Sinaimeri   +3 more
doaj   +1 more source

A divide-and-conquer phylogenomic approach based on character supermatrices resolves early steps in the evolution of the Archaea

BMC Ecology and Evolution, 2022
Background The recent rise in cultivation-independent genome sequencing has provided key material to explore uncharted branches of the Tree of Life. This has been particularly spectacular concerning the Archaea, projecting them at the center stage as ...
Monique Aouad, Jean-Pierre Flandrois, Frédéric Jauffrit, Manolo Gouy, Simonetta Gribaldo, Céline Brochier-Armanet   +5 more
doaj   +1 more source

Wolbachia load variation in Drosophila is more likely caused by drift than by host genetic factors

Peer Community Journal, 2021
Symbiosis is a continuum of long-term interactions ranging from mutualism to parasitism, according to the balance between costs and benefits for the protagonists.
Bénard, Alexis, Henri, Hélène, Noûs, Camille, Vavre, Fabrice, Kremer, Natacha   +4 more
doaj   +1 more source