Results 111 to 120 of about 1,859,513 (388)
Molecular Oncology, EarlyView.This study simultaneously investigated circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients. The elevated expression of JUNB and CXCR4 in CTCs was a poor prognostic factor for SCLC patients, whereas exosomal overexpression of these biomarkers revealed a high discrimination ability of patients from healthy individuals,
Dimitrios Papakonstantinou +13 more
wiley +1 more source
Evaluation of Treatment Effect Modification by Biomarkers Measured Pre- and Post-randomization in the Presence of Non-monotone Missingness [PDF]
arXiv, 2017 In vaccine studies, investigators are often interested in studying effect modifiers of clinical treatment efficacy by biomarker-based principal strata, which is useful for selecting biomarker study endpoints for evaluating treatments in new trials, exploring biological mechanisms of clinical treatment efficacy, and studying mediators of clinical ...
arxiv
Molecular Oncology, EarlyView.This study explores how sepsis affects GC progression by creating an immunosuppressive environment. Our findings reveal that sepsis promotes immune dysregulation, enhancing tumor growth and metastasis. Targeting the PD‐1/PD‐L1 pathway with monoclonal antibodies shows potential for restoring immune function and improving outcomes in cancer patients ...
Yiding Wang +10 more
wiley +1 more source
Frontiers in Neuroscience, 2020 Leucine-rich repeat kinase 2 (LRRK2) mutations are among the most significant genetic risk factors for developing late onset Parkinson’s disease (PD). To understand whether a therapeutic can modulate LRRK2 levels as a potential disease modifying strategy,
Omar S. Mabrouk +5 more
doaj +1 more source
The Vegetation Red Edge Spectroscopic Feature as a Surface Biomarker [PDF]
arXiv, 2002 The search for Earth-like extrasolar planets is in part motivated by the potential detection of spectroscopic biomarkers. Spectroscopic biomarkers are spectral features that are either consistent with life, indicative of habitability, or provide clues to a planet's habitability. Most attention so far has been given to atmospheric biomarkers, gases such
arxiv
Molecular Oncology, EarlyView.Consensus molecular subtypes (CMS1‐4) have been identified to study colorectal cancer heterogeneity and serve as potential biomarkers. In this study, we developed and evaluated NanoCMSer, a NanoString‐based classifier using 55 genes, optimized for FF and FFPE to facilitate the clinical evaluation of CMS subtyping.
Arezo Torang +10 more
wiley +1 more source
Efficient screening of predictive biomarkers for individual treatment selection [PDF]
arXiv, 2019 The development of molecular diagnostic tools to achieve individualized medicine requires identifying predictive biomarkers associated with subgroups of individuals who might receive beneficial or harmful effects from different available treatments.
arxiv
Clinical Cancer Research, 2019 Purpose: Complete and timely tissue genotyping is challenging, leading to significant numbers of patients with newly diagnosed metastatic non–small cell lung cancer (mNSCLC) being undergenotyped for all eight genomic biomarkers recommended by ...
N. Leighl +10 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Tumor microenvironment drives cancer formation and progression. We analyzed the role of human cancer‐associated adipocytes from patients with renal cell carcinoma (RCC) stratified as lean, overweight, or obese. RNA‐seq demonstrated that, among the most altered genes involved in the tumor–stroma crosstalk, are ADAM12 and CYP1B1, which were proven to be ...
Sepehr Torabinejad +13 more
wiley +1 more source
Analytical and Bioanalytical Chemistry, 2011 Boguslaw, Buszewski, Jochen, Schubert
openaire +3 more sources