Results 131 to 140 of about 1,859,513 (388)
Molecular Oncology, EarlyView.CD226+CD8+ T cells express elevated levels of RUNX2, exhibit higher proliferation capacity, cytokines and cytolytic molecules expression, and migratory capacity. In contrast, CD226−CD8+ T cells display an exhausted phenotype associated with the increased expression of co‐inhibitory receptors and impaired effector functions.
Maryam Rezaeifar +4 more
wiley +1 more source
Graph-Based Biomarker Discovery and Interpretation for Alzheimer's Disease [PDF]
arXivEarly diagnosis and discovery of therapeutic drug targets are crucial objectives for the effective management of Alzheimer's Disease (AD). Current approaches for AD diagnosis and treatment planning are based on radiological imaging and largely inaccessible for population-level screening due to prohibitive costs and limited availability. Recently, blood
arxiv
Extensions of net reclassification improvement calculations to measure usefulness of new biomarkers
Statistics in Medicine, 2011 Appropriate quantification of added usefulness offered by new markers included in risk prediction algorithms is a problem of active research and debate.
M. Pencina, R. D'Agostino, E. Steyerberg
semanticscholar +1 more source
Molecular Oncology, EarlyView.Pancreatic ductal adenocarcinoma (PDAC) is a disease with very poor prognosis due to therapeutic limitations. We investigated the antitumor effects of cystatin A (CSTA) in PDAC murine models. We are first to confirm that CSTA enhances T helper type 1‐mediated antitumor effects through promotion of dendritic cells and M1 macrophage activity. CSTA can be
Alessandro Nasti +8 more
wiley +1 more source
Resting-state functional connectivity-based biomarkers and functional MRI-based neurofeedback for psychiatric disorders: a challenge for developing theranostic biomarkers [PDF]
arXiv, 2017 Psychiatric research has been hampered by an explanatory gap between psychiatric symptoms and their neural underpinnings, which has resulted in poor treatment outcomes. This situation has prompted us to shift from symptom-based diagnosis to data-driven diagnosis, aiming to redefine psychiatric disorders as disorders of neural circuitry.
arxiv
Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer
Molecular Oncology, EarlyView.mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia +17 more
wiley +1 more source
Machine Learning Driven Biomarker Selection for Medical Diagnosis [PDF]
arXivRecent advances in experimental methods have enabled researchers to collect data on thousands of analytes simultaneously. This has led to correlational studies that associated molecular measurements with diseases such as Alzheimer's, Liver, and Gastric Cancer.
arxiv
Conditional Screening for Ultra-high Dimensional Covariates with Survival Outcomes [PDF]
arXiv, 2016 Identifying important biomarkers that are predictive for cancer patients' prognosis is key in gaining better insights into the biological influences on the disease and has become a critical component of precision medicine. The emergence of large-scale biomedical survival studies, which typically involve excessive number of biomarkers, has brought high ...
arxiv
Lignin pyrolysis products: Their structures and their significance as biomarkers [PDF]
, 1986 Cesáreo Sáiz‐Jiménez, J.W. de Leeuw
openalex +1 more source
Biomarkers for predicting efficacy of PD-1/PD-L1 inhibitors
Molecular Cancer, 2018 Programmed cell death protein 1/programmed cell death ligand 1 (PD-1/PD-L1) is a negative modulatory signaling pathway for activation of T cell. It is acknowledged that PD-1/PD-L1 axis plays a crucial role in the progression of tumor by altering status ...
Ming Yi +6 more
semanticscholar +1 more source